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These abnormalities are identical, in their nature and kinetics, to those observed upon inactivating Rxrb in the whole organism, thereby demonstrating that all reproductive functions of RXRB are carried out in SC. The RxrbSer\u2212\/\u2212 testis degeneration is a consequence of a cholesterol ester cell overload occurring in SC in response to reduced ABCA1- and SCARB1-mediated cholesterol efflux. The failure of spermiation was also reported in mice lacking the retinoic acid (RA) receptor-\u03b1 (RARA) in SC (RaraSer\u2212\/\u2212 mutants) and represents, in addition, a feature of vitamin A deficiency that can be readily induced in mice lacking the lecithin:retinol acyltransferase (Lrat\u2212\/\u2212 mutants). Altogether, these findings support the conclusion that RXRB heterodimerized with a RA-liganded RARA transduces signals required in SC for spermatid release.<\/jats:p>","DOI":"10.1530\/rep-08-0235","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T22:58:35Z","timestamp":1219186715000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":50,"title":["Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation"],"prefix":"10.1093","volume":"136","author":[{"given":"Nad\u00e8ge","family":"Vernet","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC) Inserm U596, CNRS UMR7104, Illkirch F-67400, France 2Universit\u00e9 Louis Pasteur Strasbourg F-67000, France 3Department of Neurobiology Jules Stein Eye Institute, University of California, Los Angeles 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