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Effects on exploration, anxiety, and social behavior resulting from inhibition of 3\u03b1,5\u03b1-THP formation, as well as 3\u03b1,5\u03b1-THP enhancement, were investigated in the midbrain VTA. Naturally sexually receptive, female rats (n=8\u201310\/group) received infusions aimed at the midbrain VTA of vehicle, PK11195 (an inhibitor of neurosteroidogenesis), and\/or indomethacin (an inhibitor of 3\u03b1,5\u03b1-THP formation from prohormones), and were subsequently infused with vehicle or FGIN 1-27 (a neurosteroidogenesis enhancer). The rats were then assessed in a behavioral battery that examined exploration (open field), anxiety (elevated plus maze), social (social interaction), and sexual (paced mating) behavior. Inhibition of 3\u03b1,5\u03b1-THP formation decreased exploratory, anti-anxiety, social, and sexual behavior, as well as midbrain 3\u03b1,5\u03b1-THP levels. Infusions of FGIN 1-27 following 3\u03b1,5\u03b1-THP inhibition restored these behaviors and midbrain 3\u03b1,5\u03b1-THP levels to those commensurate with control rats that had not been administered inhibitors. These findings suggest that 3\u03b1,5\u03b1-THP formation in the midbrain VTA may influence appetitive, as well as consummatory, aspects of mating behavior.<\/jats:p>","DOI":"10.1530\/rep-08-0250","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T20:25:56Z","timestamp":1222374356000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":24,"title":["Increasing 3\u03b1,5\u03b1-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats"],"prefix":"10.1093","volume":"137","author":[{"given":"Cheryl A","family":"Frye","sequence":"first","affiliation":[{"name":"Department of Psychology 2Department of Biological Sciences 3The Centers for Neuroscience 4Life Sciences Research 1058 The University at Albany-SUNY, 1400 Washington Avenue, Albany, New York 12222, 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