{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:13:10Z","timestamp":1767834790180,"version":"3.49.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent reports have shown that glucocorticoids can modulate oocyte maturation in both teleost fish and mammals. Within potential target cells, the actions of physiological glucocorticoids are modulated by 11\u03b2-hydroxysteroid dehydrogenase (HSD11B) isoenzymes that catalyse the interconversion of cortisol and cortisone. Hence, the objective of this study was to establish whether HSD11B enzymes mediate cortisol\u2013cortisone metabolism in porcine oocytes and, if so, whether the rate of glucocorticoid metabolism changes during oocyte maturation. Enzyme activities were measured in cumulus\u2013oocyte complexes (COCs) and denuded oocytes (DOs) using radiometric conversion assays. While COCs and DOs oxidised cortisol to inert cortisone, there was no detectable regeneration of cortisol from cortisone. The rate of cortisol oxidation was higher in expanded COCs than in compact COCs containing germinal vesicle (GV) stage oocytes (111\u00b16 vs 2041\u00b1115\u200afmol cortisone\/oocyte.24\u200ah; P&amp;lt;0.001). Likewise, HSD11B activities were 17\u00b11 fold higher in DOs from expanded COCs than in those from compact COCs (P&amp;lt;0.001). When GV stage oocytes were subject to a 48\u200ah in vitro maturation protocol, the enzyme activities were significantly increased from 146\u00b118 to 1857\u00b1276\u200afmol cortisone\/oocyte.24\u200ah in GV versus MII stage oocytes respectively (P&amp;lt;0.001). Cortisol metabolism was inhibited by established pharmacological inhibitors of HSD11B (glycyrrhetinic acid and carbenoxolone), and by porcine follicular and ovarian cyst fluid. We conclude that an HSD11B enzyme (or enzymes) functions within porcine oocytes to oxidise cortisol, and that this enzymatic inactivation of cortisol increases during oocyte maturation.<\/jats:p>","DOI":"10.1530\/rep-08-0289","type":"journal-article","created":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T20:55:10Z","timestamp":1221166510000},"page":"725-732","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":13,"title":["Inactivation of glucocorticoids by 11\u03b2-hydroxysteroid dehydrogenase enzymes increases during the meiotic maturation of porcine oocytes"],"prefix":"10.1093","volume":"136","author":[{"given":"Rachel J","family":"Webb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neera","family":"Sunak","sequence":"additional","affiliation":[{"name":"Division of Clinical Developmental Sciences Academic Section of Obstetrics and Gynaecology, Centre for Developmental and Endocrine Signalling, St George's University of London, Level 3 Lanesborough Wing, Cranmer Terrace, London SW17 0RE, UK 1Department of Biochemistry and Molecular Biology University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Wren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony E","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"2026010712483175400_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0167-4838(95)00005-F","article-title":"Mutations in the putative glycosylation sites of rat 11\u03b2-hydroxysteroid dehydrogenase affect enzyme activity","volume":"1248","author":"Agarwal","year":"1995","journal-title":"Biochimica et Biophysica 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