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To obtain a CL functional for 9\u00b11 days, immature female mice of the BALB\/c strain were injected i.p. with 10\u200aIU\/mouse of pregnant mare's serum gonadotropin (PMSG). DHEA (60\u200amg\/kg body weight s.c., 24 and 48\u200ah prior to kill) decreased both serum progesterone (P) and estradiol (E2) levels and increased the activity of superoxide dismutase (SOD) from ovaries with functional CL (on day 5 after PMSG). It increased P and E2 and the activities of SOD and catalase (CAT) and decreased lipoperoxidation of ovaries with regressing CL (on day 9 after PMSG). Treatment with DHEA did not affect the production of prostaglandin F2\u03b1 (PGF2\u03b1) or PGE by ovaries with functional CL, whereas DHEA decreased PGF2\u03b1 and increased PGE production by ovaries with regressing CL. Metformin (50\u200amg\/kg body weight, orally) given together with DHEA restored E2 levels from mice with ovaries with functional CL and serum P, PGF2\u03b1 and PGE levels, and oxidative balance in mice with ovaries with regressing CL. Metformin alone was able to modulate serum P and E2 levels, lipoperoxidation, SOD and CAT, and the 5,5-dimethyl-1-pyrroline N-oxide\/\u2022OH signal. These findings suggest that hyperandrogenism is able to induce or to rescue CL from luteolysis and metformin treatment is able to prevent these effects.<\/jats:p>","DOI":"10.1530\/rep-08-0325","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T21:02:04Z","timestamp":1244235724000},"page":"571-579","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["Effect of DHEA and metformin on corpus luteum in mice"],"prefix":"10.1093","volume":"138","author":[{"given":"Valeria A","family":"Sander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela B","family":"Facorro","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Ov\u00e1rica- Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO) Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET)- Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina 1C\u00e1tedra de F\u00edsica. Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires, Jun\u00edn 954, 1121 Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Piehl","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Ov\u00e1rica- Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO) Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET)- Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina 1C\u00e1tedra de F\u00edsica. Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires, Jun\u00edn 954, 1121 Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Rub\u00edn de Celis","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Ov\u00e1rica- Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO) Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET)- Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina 1C\u00e1tedra de F\u00edsica. Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires, Jun\u00edn 954, 1121 Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia B","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"2026010712512867000_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010712512867000_bib2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbagen.2005.06.018","article-title":"Changes in activities of superoxide dismutase, nitric oxide synthase, glutathione-dependent enzymes and the incidence of apoptosis in sheep corpus luteum during the estrous 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