{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:39:23Z","timestamp":1790883563487,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The first round of mouse spermatogenesis begins from 3 to 4 days after birth through differentiation of gonocytes into spermatogonial-stem cells and type A spermatogonia. Consequently, this step of differentiation may determine generation of the original population of stem cells and the fertility potential of the adult mouse. We aimed to determine the effect of perinatal exposure to ionizing radiation on the testis at the end of the first wave of spermatogenesis and at sexual maturity. Our results show that, radiation sensitivity of the testis substantially decreases from late foetal life to the end of the first week after birth. In addition, partial or full recovery from radiation induced testicular weight loss occurred between the first round of spermatogenesis and sexual maturity, and this was associated with the stimulation of spermatogonial proliferation. Exposure of mice at 17.5 days after conception or at 1 day after birth to \u03b3-rays decreased the sperm counts at sexual maturity, while exposure of 8 day-old mice had no effect. This suggests that irradiation of late foetal or early neonatal testes has a direct impact on the generation of the neonatal spermatogonial-stem cell pool.<\/jats:p>","DOI":"10.1530\/rep-08-0358","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T20:26:09Z","timestamp":1230150369000},"page":"487-495","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["Exposure of the mouse perinatal testis to radiation leads to hypospermia at sexual maturity"],"prefix":"10.1093","volume":"137","author":[{"given":"A","family":"Forand","sequence":"first","affiliation":[{"name":"Laboratory of Differentiation and Radiobiology of the Gonads CEA, DSV, iRCM, SCSR, Fontenay aux Roses F-92265, France 2Unit of Gametogenesis and Genotoxicity Universit\u00e9 Paris 7 Denis Diderot, Fontenay aux Roses F-92265, France 3INSERM U566, Fontenay aux Roses F-92265, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Messiaen","sequence":"additional","affiliation":[{"name":"Laboratory of Differentiation and Radiobiology of the Gonads CEA, DSV, iRCM, SCSR, Fontenay aux Roses F-92265, France 2Unit of Gametogenesis and Genotoxicity Universit\u00e9 Paris 7 Denis Diderot, Fontenay aux Roses F-92265, France 3INSERM U566, Fontenay aux Roses F-92265, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Habert","sequence":"additional","affiliation":[{"name":"Laboratory of Differentiation and Radiobiology of the Gonads CEA, DSV, iRCM, SCSR, Fontenay aux Roses F-92265, France 2Unit of Gametogenesis and Genotoxicity Universit\u00e9 Paris 7 Denis Diderot, Fontenay aux Roses F-92265, France 3INSERM U566, Fontenay aux Roses F-92265, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bernardino-Sgherri","sequence":"additional","affiliation":[{"name":"Laboratory of Differentiation and Radiobiology of the Gonads CEA, DSV, iRCM, SCSR, Fontenay aux Roses F-92265, France 2Unit of Gametogenesis and Genotoxicity Universit\u00e9 Paris 7 Denis Diderot, Fontenay aux Roses F-92265, France 3INSERM U566, Fontenay aux Roses F-92265, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2026010712494582700_bib1","first-page":"503","article-title":"Sertoli cell death by apoptosis in the immature rat testis following x-irradiation","volume":"2","author":"Allan","year":"1988","journal-title":"Scanning Microscopy"},{"key":"2026010712494582700_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2605.2007.00853.x","article-title":"Adverse trends in male reproductive health: we may have reached a crucial \u2018tipping point\u2019","volume":"31","author":"Andersson","year":"2008","journal-title":"International Journal of Andrology"},{"key":"2026010712494582700_bib3","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1210\/en.2008-0349","article-title":"Platelet-derived growth factor receptor \u03b2-subtype regulates proliferation and migration of gonocytes","volume":"149","author":"Basciani","year":"2008","journal-title":"Endocrinology"},{"key":"2026010712494582700_bib4","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1095\/biolreprod63.6.1893","article-title":"Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse","volume":"63","author":"Beumer","year":"2000","journal-title":"Biology of Reproduction"},{"key":"2026010712494582700_bib5","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(97)10514-1","article-title":"Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners","volume":"352","author":"Bonde","year":"1998","journal-title":"Lancet"},{"key":"2026010712494582700_bib6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/j.1939-4640.1983.tb00765.x","article-title":"The effect of testicular x-irradiation on spermatogenesis in man. 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