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There were three groups: 1) a control group (n=24), 2) a group of castrated mice (n=24), and 3) a group in which OTT (n=24) was performed. Morphologically, the transplanted testes showed active spermatogenesis and normal structure of epididymis at 4 and 5 weeks. The function of the transplants was examined by RIA at designed time points. LH, FSH, and testosterone showed return to normal levels at 4 weeks. To our knowledge, this is the first report of successful revascularized OTT in mice. The model may prove useful in research in reproductive medicine, especially using knockout and transgenic mice.<\/jats:p>","DOI":"10.1530\/rep-08-0464","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T20:58:58Z","timestamp":1258145938000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":4,"title":["Orthotopic testicular transplantation in mice"],"prefix":"10.1093","volume":"139","author":[{"given":"Jianhui","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Organ Transplantation Key Laboratory of Combined Multi-organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, Ministry of Public Health, Medical College, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, People's Republic of China 2Service de M\u00e9decine Intensive Adulte et Division de Physiopathologie CHUV-1010 Lausanne, Switzerland 3Department of Cardiovascular Surgery University Hospital, 3010 Berne, Switzerland 4Department of Urology College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Savolainen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Transplantation Key Laboratory of Combined Multi-organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, Ministry of Public Health, Medical College, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, People's Republic of China 2Service de M\u00e9decine Intensive Adulte et Division de Physiopathologie CHUV-1010 Lausanne, Switzerland 3Department of Cardiovascular Surgery University Hospital, 3010 Berne, Switzerland 4Department of Urology College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FuQing","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Transplantation Key Laboratory of Combined Multi-organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, Ministry of Public Health, Medical College, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, People's Republic of China 2Service de M\u00e9decine Intensive Adulte et Division de Physiopathologie CHUV-1010 Lausanne, Switzerland 3Department of Cardiovascular Surgery University Hospital, 3010 Berne, Switzerland 4Department of Urology College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Transplantation Key Laboratory of Combined Multi-organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, Ministry of Public Health, Medical College, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, People's Republic of China 2Service de M\u00e9decine Intensive Adulte et Division de Physiopathologie CHUV-1010 Lausanne, Switzerland 3Department of Cardiovascular Surgery University Hospital, 3010 Berne, Switzerland 4Department of Urology College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"2026010712524383400_bib1","first-page":"390","article-title":"Technique for testicular transplants","volume":"3","author":"Attaran","year":"1966","journal-title":"Investigative 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