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Disruption in steroid receptor expression affects follicle formation and differentiation. In this study, using prenatal testosterone (T) and dihydrotestosterone (DHT)-treated female sheep as model systems, we tested the hypothesis that prenatal androgen excess disrupts the developmental ontogeny of ovarian steroid receptor protein expression. Pregnant Suffolk ewes were injected twice weekly with T propionate or DHT propionate (a non-aromatizable androgen) in cottonseed oil from days 30 to 90 of gestation. Changes in ovarian estrogen receptors (ER; ESR1, ESR2), androgen receptor (AR) and progesterone receptor (PGR) proteins were determined at fetal (days 90 and 140), postpubertal (10 months), and adult (21 months; only prenatal T-treated sheep studied) ages by immunohistochemistry. Prenatal T and DHT treatment induced selective increase in AR but not ER or PGR expression in the stroma and granulosa cells of fetal days 90 and 140 ovaries. An increase in ESR1 and decrease in ESR2 immunostaining coupled with increased AR expression were evident in granulosa cells of antral follicles of 10- and 21-month-old prenatal T but not DHT-treated females (analyzed only at 10 months). These findings provide evidence that an early increase in ovarian AR is the first step in the altered ovarian developmental trajectory of prenatal T-treated females, and manifestations of postnatal ovarian dysfunction are likely facilitated via altered equilibrium of antral follicular granulosa cell ER\/AR protein expression.<\/jats:p>","DOI":"10.1530\/rep-08-0491","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T21:38:10Z","timestamp":1236202690000},"page":"865-877","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":119,"title":["Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance"],"prefix":"10.1093","volume":"137","author":[{"given":"Hugo H","family":"Ortega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia R","family":"Salvetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Faculty of Veterinary Sciences, National University of Litoral, Esperanza 3800, Santa Fe, Argentina and Argentine National Research Council (CONICET) 1Department of Pediatrics and the Reproductive Sciences Program University of Michigan, 300 North Ingalls Building, Room 1109 SW, Ann Arbor, Michigan 48109-0404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2026010712492271600_bib1","first-page":"259","article-title":"Animal models and fetal programming of PCOS","volume-title":"Contemporary Endocrinology: Androgen Excess Disorders in Women: Polycystic Ovary Syndrome and Other Disorders","author":"Abbott","year":"2006","edition":"2 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