{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:42:36Z","timestamp":1784673756333,"version":"3.55.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The influences of dietary fumonisin B1 (FB1), a metabolite of Fusarium verticillioides, on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits (bucks) were studied. Forty male rabbits were randomly assigned and fed four diets containing 0.13, 5.0, 7.5 and 10.0\u200amg FB1\/kg, constituting diets 1 (control), 2, 3 and 4 respectively, for a period of 175 days in a completely randomized design. During the last week of the feeding trial, two untreated female rabbits were mated to each of the four treated bucks per treatment to assess the fertility rate of the treated bucks. Onset of puberty in animals fed diets 3 and 4 was significantly (P&amp;lt;0.05) delayed by some 9\u201312 days. The weight at puberty, sperm concentration and total sperm\/ejaculate were not significantly influenced by the dietary FB1. Sperm mass activities, motility and live spermatozoa of the rabbits' semen significantly (P&amp;lt;0.05) declined with an increase in the dietary FB1. The highest sperm cell abnormalities were recorded in the animals fed 10.0\u200amg\/kg FB1, while the least was observed in the control animals. The conception rate, litter size and embryo survival rate were statistically the same among the dietary treatments. Embryo mortality was significantly (P&amp;lt;0.05) higher in rabbits fed diets 3 and 4 than in others. Testicular elements were significantly (P&amp;lt;0.05) impaired by the toxin in rabbits fed 7.5 and 10.0\u200amg FB1\/kg. This suggests that LOAEL of 7.50\u200amg\/kg FB1 delayed puberty, impaired semen quality and spermatogenesis and induced embryo mortality without a statistically adverse effect on the fertility rates of male rabbits.<\/jats:p>","DOI":"10.1530\/rep-09-0077","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T21:29:04Z","timestamp":1258406944000},"page":"439-445","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":42,"title":["Effects of dietary fumonisin B1 on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits"],"prefix":"10.1093","volume":"139","author":[{"given":"E O","family":"Ewuola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G N","family":"Egbunike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"2026010712522461200_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1039\/c39880000743","article-title":"Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme","volume":"1988","author":"Bezuidenhout","year":"1988","journal-title":"Journal of the Chemical Society. Chemical Communications"},{"key":"2026010712522461200_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/009841098159411","article-title":"Gavage administration of the fungal toxin fumonisin B1 to female Sprague\u2013Dawley rats","volume":"53","author":"Bondy","year":"1998","journal-title":"Journal of Toxicology and Environmental Health"},{"key":"2026010712522461200_bib3","first-page":"92","article-title":"In vitro assessment of fumonisin B1 toxicity using reaggregate cultures of chick embryo neural retina cells (CERC)","volume":"30A","author":"Bradlaw","year":"1994","journal-title":"In vitro Cellular & Developmental Biology"},{"key":"2026010712522461200_bib4","first-page":"167","article-title":"Characterization and androgen dependence of bull","volume":"146","author":"Brooks","year":"1980","journal-title":"American Journal of Anatomy"},{"key":"2026010712522461200_bib5","first-page":"66","article-title":"The effects of micro doses of aflatoxin B1 on sperm production rates, epididymal sperm abnormality and fertility in the rats","volume":"26","author":"Egbunike","year":"1979","journal-title":"Veterinary Medicine A"},{"key":"2026010712522461200_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.51791\/njap.v6i.2657","article-title":"Comparative studies on the reproductive capacity of Nigerian and exotic poultry breeds","volume":"6","author":"Egbunike","year":"1979","journal-title":"Nigerian Journal of Animal Production"},{"key":"2026010712522461200_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1439-0531.1976.tb00310.x","article-title":"Reproductive capacity of German Landrace boars II. Sperm production rates as determined by quantitative testicular histology and from gonadal sperm reserves","volume":"11","author":"Egbunike","year":"1975","journal-title":"Zuchthygiene"},{"key":"2026010712522461200_bib8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1439-0396.2008.00862.x","article-title":"Organs traits and histopathology of rabbits fed varied levels of dietary fumonisin B1","volume":"93","author":"Ewuola","year":"2009","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"key":"2026010712522461200_bib9","first-page":"4304","article-title":"Haematological and serum biochemical response of growing rabbit bucks fed different levels of dietary fumonisin B1","volume":"7","author":"Ewuola","year":"2008","journal-title":"African Journal of Biotechnology"},{"key":"2026010712522461200_bib10","first-page":"111","article-title":"Performance evaluation and organ histology of rabbits fed Fusarium verticillioides culture material","volume":"6","author":"Ewuola","year":"2003","journal-title":"Tropical Animal Production Investigation"},{"key":"2026010712522461200_bib11","first-page":"257","article-title":"Growth response of rabbit bucks fed dietary fumonisin B1","volume":"10","author":"Ewuola","year":"2007","journal-title":"Tropical Journal of Animal Science"},{"key":"2026010712522461200_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11046-007-9083-y","article-title":"Physiological response of rabbit bucks to dietary fumonisin: performance, haematology and serum biochemistry","volume":"165","author":"Ewuola","year":"2008","journal-title":"Mycopathologia"},{"key":"2026010712522461200_bib13"},{"key":"2026010712522461200_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0021-9150(92)90183-H","article-title":"Atherogenic effects in a non-human primate of Fusarium moniliforme cultures added to a carbohydrate diet","volume":"94","author":"Fincham","year":"1992","journal-title":"Atherosclerosis"},{"key":"2026010712522461200_bib15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.anireprosci.2007.11.006","article-title":"Testicular and epididymal sperm reserves and sperm production of pubertal boars fed dietary fumonisin B1","volume":"105","author":"Gbore","year":"2008","journal-title":"Animal Reproduction Science"},{"key":"2026010712522461200_bib16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.51791\/njap.v34i2.1215","article-title":"Spermatogenesis gonadal sperm reserves and fertility of rabbits fed varied micro doses of dietary fumonisin","volume":"34","author":"Gbore","year":"2007","journal-title":"Nigerian Journal of Animal Production"},{"key":"2026010712522461200_bib17","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/carcin\/12.7.1247","article-title":"Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats","volume":"12","author":"Gelderblom","year":"1991","journal-title":"Carcinogenesis"},{"key":"2026010712522461200_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/carcin\/15.2.209","article-title":"Fumonisin B1 dosimetry in relation to cancer initiation in rat liver","volume":"15","author":"Gelderblom","year":"1994","journal-title":"Carcinogenesis"},{"key":"2026010712522461200_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0166-445X(94)00050-6","article-title":"Sphingolipid levels in catfish consuming Fusarium moniliforme corn culture material containing fumonisins","volume":"30","author":"Goel","year":"1994","journal-title":"Aquatic Toxicology"},{"key":"2026010712522461200_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/nt.2620030512","article-title":"Effects of intravenous fumonisin B1 in rabbits: nephrotoxicity and sphingolipid alterations","volume":"3","author":"Gumprecht","year":"1995","journal-title":"Natural Toxins"},{"key":"2026010712522461200_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/104063879000200312","article-title":"Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme","volume":"2","author":"Harrison","year":"1990","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"2026010712522461200_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3382\/ps.0380301","article-title":"Seasonal variation in semen characteristics of adult Fayomi Cocks","volume":"38","author":"Kamar","year":"1959","journal-title":"Poultry Science"},{"key":"2026010712522461200_bib23","first-page":"269","article-title":"Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1","volume":"57","author":"Kellerman","year":"1990","journal-title":"Onderstepoort Journal of Veterinary Research"},{"key":"2026010712522461200_bib24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/faat.1997.2380","article-title":"Lack of embryo toxicity of fumonisin B1 in New Zealand white rabbits","volume":"40","author":"LaBorde","year":"1997","journal-title":"Fundamental and Applied Toxicology"},{"key":"2026010712522461200_bib25","first-page":"239","article-title":"Discovery and occurrence of the fumonisins: a historical perspective","volume":"109","author":"Marasas","year":"2001","journal-title":"Environmental Health Perspectives"},{"key":"2026010712522461200_bib26","first-page":"197","article-title":"Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme","volume":"55","author":"Marasas","year":"1988","journal-title":"Onderstepoort Journal of Veterinary Research"},{"key":"2026010712522461200_bib27","doi-asserted-by":"crossref","first-page":"27299","DOI":"10.1016\/S0021-9258(19)74249-5","article-title":"Fumonisin B1 inhibits sphingosine (sphinganine) N-acetyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ","volume":"268","author":"Merrill","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712522461200_bib28","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1128\/aem.57.8.2410-2412.1991","article-title":"Production of fumonisins by Fusarium moniliforme strains from various substrates and geographic areas","volume":"57","author":"Nelson","year":"1991","journal-title":"Applied and Environmental Microbiology"},{"key":"2026010712522461200_bib29","first-page":"35","article-title":"Testicular and epididymal sperm reserves of rabbits fed fumonisin contaminated diets","volume":"1","author":"Ogunlade","year":"2006","journal-title":"World Applied Sciences Journal"},{"key":"2026010712522461200_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1095\/biolreprod24.2.431","article-title":"Surface changes in rat spermatozoa during epididymal transit","volume":"24","author":"Olson","year":"1981","journal-title":"Biology of Reproduction"},{"key":"2026010712522461200_bib31","first-page":"20","article-title":"Effect of aflatoxin Bi on reproduction in rats","volume":"7","author":"Panda","year":"1970","journal-title":"Journal of Food Science and Technology"},{"key":"2026010712522461200_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/02652039609374393","article-title":"Disposition of 14C \u2013 derived residues in tissues of pigs fed radiolabelled fumonisin B1","volume":"13","author":"Prelusky","year":"1996","journal-title":"Food Additives and Contaminants"},{"key":"2026010712522461200_bib33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1094\/Phyto-82-353","article-title":"Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei","volume":"82","author":"Rheeder","year":"1992","journal-title":"Phytopathology"},{"key":"2026010712522461200_bib34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/jaoac\/77.2.533","article-title":"Liquid chromatographic determination of sphinganine and sphingosine: use of the free sphinganine \u2013 to \u2013 sphingosine ratio as a biomarker for consumption of fumonisins","volume":"77","author":"Riley","year":"1994","journal-title":"Journal of AOAC International"},{"key":"2026010712522461200_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/19960401NT2","article-title":"Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and the carcinogenicity of fumonisin","volume":"4","author":"Riley","year":"1996","journal-title":"Natural Toxins"},{"key":"2026010712522461200_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00497286","article-title":"A review and update of animal toxicoses associated with fumonisin contaminated feeds and production of fumonisins by Fusarium isolates","volume":"117","author":"Ross","year":"1992","journal-title":"Mycopathology"},{"key":"2026010712522461200_bib37","volume-title":"SAS\/STAT User's Guide. Version 8 for Windows","author":"SAS Institute Inc","year":"1999"},{"key":"2026010712522461200_bib38","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/jaoac\/79.3.671","article-title":"Worldwide survey of fumonisin contamination of corn and corn \u2013 based products","volume":"79","author":"Shephard","year":"1996","journal-title":"Journal of AOAC International"},{"key":"2026010712522461200_bib39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4141\/cjas66-016","article-title":"Structural composition of shorthorn bull testes and daily spermatozoa production as determined by quantitative testicular history","volume":"46","author":"Swierstra","year":"1966","journal-title":"Canadian Journal of Animal Science"},{"key":"2026010712522461200_bib40"},{"key":"2026010712522461200_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/19960401NT4","article-title":"Studies on the reproductive effects of Fusarium moniliforme culture material in rats and the biodistribution of [14C] fumonisin B1 in pregnant rats","volume":"4","author":"Voss","year":"1996","journal-title":"Natural Toxins"},{"key":"2026010712522461200_bib42","volume-title":"Fumonisin B1. Environmental Health Criteria 219","author":"WHO","year":"2000"},{"key":"2026010712522461200_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-008X(92)90090-F","article-title":"Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC \u2013 PK1 cells","volume":"114","author":"Yoo","year":"1992","journal-title":"Toxicology and Applied Pharmacology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/139\/2\/439.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/139\/2\/439\/64532204\/439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/139\/2\/439\/64532204\/439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:56:34Z","timestamp":1767808594000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/139\/2\/439\/8243197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-09-0077","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,2,1]]},"published":{"date-parts":[[2010,2,1]]}}}