{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:08:34Z","timestamp":1767812914226,"version":"3.49.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our objective was to test the hypothesis that prolactin (PRL) acts at both the pituitary and testis levels to regulate testosterone secretion in the adult ram. The focus was on the mid-regression to mid-redevelopment stages of a photoperiod-condensed \u2018seasonal\u2019 testicular cycle. DLS rams (six per group) were given daily s.c. injections of bromocriptine (4\u200amg) or vehicle during the entire period. Serum PRL concentration in control rams peaked at 103.4\u00b122.1\u200ang\/ml in late regression and then steadily declined (P&amp;lt;0.01) to 19.5\u00b14.3\u200ang\/ml, whereas PRL in treated rams was always \u22644.0\u200ang\/ml. Suppression of PRL tended (P&amp;lt;0.10) to increase the amplitude of natural LH pulses (transition stages) or reduce the number of LH receptors in the testis (regressed stage), although neither change disturbed testosterone levels in peripheral blood. These subtle changes were accompanied by significant (P&amp;lt;0.05) alterations in the capability of the pituitary to release LH (85% more) and of the testes to secrete testosterone (20% less). These effects of PRL were unmasked when rams were given highly stimulative i.v. injections of GNRH (single 3\u200a\u03bcg dose) and NIH-oLH-S24 (three 5\u200a\u03bcg doses given 20\u200amin apart) respectively. PRL insufficiency also appeared to slow down the \u2018seasonal\u2019 rise in FSH secretion and slightly delayed (2 weeks) the times when the testes began to grow and were first significantly (P&amp;lt;0.05) enlarged from the regressed state. We conclude that PRL is an important part of the intricate regulation of the pituitary\u2013gonadal system in moderately seasonal DLS rams.<\/jats:p>","DOI":"10.1530\/rep-09-0180","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T23:21:45Z","timestamp":1253056905000},"page":"197-207","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":19,"title":["Prolactin regulation of testosterone secretion and testes growth in DLS rams at the onset of seasonal testicular recrudescence"],"prefix":"10.1093","volume":"139","author":[{"given":"L M","family":"Sanford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"2026010712514823100_bib1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1095\/biolreprod22.4.781","article-title":"Prolactin, testicular growth and LH receptors in the ram following light and 2-Br-\u03b1-ergocryptine (CB-154) treatments","volume":"22","author":"Barenton","year":"1980","journal-title":"Biology of Reproduction"},{"key":"2026010712514823100_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1051\/rnd:19820504","article-title":"Effects of induced hypoprolactinemia in the ram: plasma gonadotrophin levels, LH and FSH receptors and histology of the testis","volume":"22","author":"Barenton","year":"1982","journal-title":"Reproduction, Nutrition, 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