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TGFB signals via TGFBR and activates downstream effector SMAD proteins 2 and 3 (p-SMAD2\/3). Latency-associated peptide (LAP), part of the latent TGFB complex, is known to bind to ITG heterodimers and activate TGFB. We hypothesize that active TGFBs and TGFBRs along with LAP and ITGs functionally interact at the conceptus\u2013maternal interface to mediate events essential for conceptus development and attachment in pigs. Uteri and conceptuses from days 10, 12, 16, 20, and 24 pregnant gilts were immunostained for TGFB, LAP, and ITG subunits (ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8). Activation of TGFBRs was evaluated by the presence of phosphorylated downstream effector SMAD2\/3. Binding of LAP to ITGs was also evaluated using porcine trophectoderm cells. Abundant active TGFB was detected at the apical surfaces of epithelia at the conceptus\u2013maternal interface, and p-SMAD2\/3 was detected at both conceptus attachment and nonattachment sites during implantation. Separate aggregates of LAP, ITGB1, ITGB5, and later ITGB3 were detected at the porcine conceptus\u2013maternal interface, and binding of LAP to ITGs on apical surfaces was demonstrated. Results suggest that functional LAP\u2013ITG adhesion complexes support conceptus attachment and promote TGFB activation leading to TGFB interaction with TGFBR supporting events of porcine implantation.<\/jats:p>","DOI":"10.1530\/rep-09-0447","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T22:58:44Z","timestamp":1258498724000},"page":"465-478","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":55,"title":["Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus\u2013maternal interface"],"prefix":"10.1093","volume":"139","author":[{"given":"Dana A","family":"Massuto","sequence":"first","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C","family":"Kneese","sequence":"additional","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Neil","family":"Hooper","sequence":"additional","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy H","family":"Ing","sequence":"additional","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Departments of 1Veterinary Integrative Biosciences 2Veterinary Large Animal Clinical Sciences 3Animal Science Texas A&M University, College Station, Texas 77843-4458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"2026010712534976500_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-5793(01)03280-X","article-title":"The integrin alphaVbeta6 binds and activates latent TGFbeta3","volume":"511","author":"Annes","year":"2002","journal-title":"FEBS Letters"},{"key":"2026010712534976500_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGFbeta activation","volume":"116","author":"Annes","year":"2003","journal-title":"Journal of Cell Science"},{"key":"2026010712534976500_bib3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1083\/jcb.200312172","article-title":"Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1","volume":"165","author":"Annes","year":"2004","journal-title":"Journal of Cell Biology"},{"key":"2026010712534976500_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ydbio.2005.02.009","article-title":"Blastocysts don't go it alone. 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