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In this study, we analyzed Klf4 expression in different mouse tissues using northern blot analysis and immunohistochemistry. Focusing on the male and female reproductive tract, we showed for the first time that KLF4 is expressed in the epithelia of the murine uterus and the vagina. In the male reproductive tract, we detected KLF4 in the epithelia of the epididymis, ductus deferens, coagulating gland, and the penis. As KLF4 is strongly inducible by FSH signaling in Sertoli cells and as this transcription factor is also involved in Sertoli cell development, we employed the mouse Sertoli cell line TM4 as a model system to investigate i) the induction kinetics of Klf4 upon activation of the cAMP\/protein kinase A pathway by forskolin and ii) the effects of Klf4 induction on TM4 cell cycle progression. Interestingly, Klf4 mRNA and protein were rapidly but transiently induced, reaching peak levels after 90\u2013120\u200amin and declining to basal levels within 4\u200ah. Compared with the inducible cAMP early repressor, an immediate early response gene, the induction kinetics of Klf4 is much faster. In conclusion, Klf4 is an immediate early gene in TM4 cells and its expression in several epithelia of the male and female reproductive tract suggests an important role of Klf4 in mouse reproductive functions.<\/jats:p>","DOI":"10.1530\/rep-09-0531","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T20:44:35Z","timestamp":1262724275000},"page":"771-782","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":33,"title":["Kr\u00fcppel-like factor 4 is widely expressed in the mouse male and female reproductive tract and responds as an immediate early gene to activation of the protein kinase A in TM4 Sertoli cells"],"prefix":"10.1093","volume":"139","author":[{"given":"M","family":"Godmann","sequence":"first","affiliation":[{"name":"Institute of Anatomy Developmental Biology 2Institute of Cell Biology University of Duisburg-Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany 3Department of Stem Cell Biology German Primate Center, Kellnerweg 4, D-37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kosan","sequence":"additional","affiliation":[{"name":"Institute of Anatomy Developmental Biology 2Institute of Cell Biology University of Duisburg-Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany 3Department of Stem Cell Biology German Primate Center, Kellnerweg 4, D-37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Behr","sequence":"additional","affiliation":[{"name":"Institute of Anatomy Developmental Biology 2Institute of Cell Biology University of Duisburg-Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany 3Department of Stem Cell Biology German Primate Center, Kellnerweg 4, D-37077 G\u00f6ttingen, 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