{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:18:55Z","timestamp":1776709135623,"version":"3.51.2"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Axis specification in mouse is determined by a sequence of reciprocal interactions between embryonic and extra-embryonic tissues so that a few extra-embryonic genes appear as \u2018patterning\u2019 the embryo. Considering these interactions as essential, but lacking in most mammals the genetically driven approaches used in mouse and the corresponding patterning mutants, we examined whether a molecular signature originating from extra-embryonic tissues could relate to the developmental stage of the embryo proper and predict it. To this end, we have profiled bovine extra-embryonic tissues at peri-implantation stages, when gastrulation and early neurulation occur, and analysed the subsequent expression profiles through the use of predictive methods as previously reported for tumour classification. A set of six genes (CALM1, CPA3, CITED1, DLD, HNRNPDL, and TGFB3), half of which had not been previously associated with any extra-embryonic feature, appeared significantly discriminative and mainly dependent on embryonic tissues for its faithful expression. The predictive value of this set of genes for gastrulation and early neurulation stages, as assessed on naive samples, was remarkably high (93%). In silico connected to the bovine orthologues of the mouse patterning genes, this gene set is proposed as a new trait for embryo staging. As such, this will allow saving the bovine embryo proper for molecular or cellular studies. To us, it offers as well new perspectives for developmental phenotyping and modelling of embryonic\/extra-embryonic co-differentiation.<\/jats:p>","DOI":"10.1530\/rep-10-0174","type":"journal-article","created":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T22:38:49Z","timestamp":1286404729000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":30,"title":["A small set of extra-embryonic genes defines a new landmark for bovine embryo staging"],"prefix":"10.1093","volume":"141","author":[{"given":"S\u00e9verine A","family":"Degrelle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim-Anh","family":"L\u00ea Cao","sequence":"additional","affiliation":[{"name":"INRA-ENVA UMR 1198 Biologie du D\u00e9veloppement et Reproduction, Domaine de Vilvert, F-78350 Jouy en Josas, France 1INRA UR631 Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux, F-31326 Castanet, France 2Institut de Math\u00e9matiques Universit\u00e9 de Toulouse et CNRS (UMR 5219), F-31062 Toulouse, France 3Department of Animal Sciences University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA 4INRA UE331 Unit\u00e9 Commune d'Exp\u00e9rimentation Animale de Bressonvilliers, F-91630 Leudeville, France 5Centre de Ressources Biologiques pour la G\u00e9nomique des Animaux d'Elevages et d'Int\u00e9r\u00eat Economique F-78350 Jouy-en-Josas, France 6Department of Animal Science and Center for Regenerative Biology University of Connecticut, Storrs, Connecticut 06269, USA 7Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Heyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin E","family":"Everts","sequence":"additional","affiliation":[{"name":"INRA-ENVA UMR 1198 Biologie 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Jouy-en-Josas, France 6Department of Animal Science and Center for Regenerative Biology University of Connecticut, Storrs, Connecticut 06269, USA 7Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X Cindy","family":"Tian","sequence":"additional","affiliation":[{"name":"INRA-ENVA UMR 1198 Biologie du D\u00e9veloppement et Reproduction, Domaine de Vilvert, F-78350 Jouy en Josas, France 1INRA UR631 Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux, F-31326 Castanet, France 2Institut de Math\u00e9matiques Universit\u00e9 de Toulouse et CNRS (UMR 5219), F-31062 Toulouse, France 3Department of Animal Sciences University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA 4INRA UE331 Unit\u00e9 Commune d'Exp\u00e9rimentation Animale de Bressonvilliers, F-91630 Leudeville, France 5Centre de Ressources Biologiques pour la G\u00e9nomique des Animaux d'Elevages 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