{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:51:05Z","timestamp":1767858665520,"version":"3.49.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In late pregnant cows, progesterone (P4) is mainly of luteal origin. However, the trophoblast may provide high local P4 concentrations in the uterus. To test for the importance of a complete P4 withdrawal for parturition-related processes and placental release, the P4 receptor (PGR) blocker aglepristone (Ap) was administered to three cows on days 270 and 271 of pregnancy. A complete opening of the cervix was observed 46.5\u00b17.3\u200ah after the start of treatment. However, expulsion of the calves was impaired obviously because of insufficient myometrial activity, and placental membranes were retained for at least 10 days. Measurement of P4 concentrations indicated that PGR blockage induced luteolysis. To investigate the role of P4 withdrawal for the prepartal tissue remodeling of the placentomes, the caruncular epithelium was evaluated by morphometry, and the percentage of trophoblast giant cells (TGCs) relative to the total number of trophoblast cells were assessed. Caruncular epithelium in Ap-treated cows (D272+Ap) was immature (30.5\u00b13.3%) and not different from untreated controls (elected cesarean section (CS) on day 272; D272-CS; 31.5\u00b11.4%), whereas it was significantly reduced at normal term (D280.5\u00b11.3; 21.0\u00b16.1%; P=0.011). Correspondingly, the percentage of TGCs were 20.1\u00b11.4 in D272+Ap, 22.1\u00b14.8 in D272-CS, and 9.8\u00b13.9 at term (P=0.001). No effect was detected on placental estrogen synthesis. The results showed that in late pregnant cows, P4 withdrawal only induces a limited spectrum of the processes related to normal parturition and is not a crucial factor for the prepartal tissue remodeling in placentomes and the timely release of the placenta.<\/jats:p>","DOI":"10.1530\/rep-10-0182","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T18:55:34Z","timestamp":1278874534000},"page":"623-632","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":15,"title":["Use of the progesterone (P4) receptor antagonist aglepristone to characterize the role of P4 withdrawal for parturition and placental release in cows"],"prefix":"10.1093","volume":"140","author":[{"given":"Sima","family":"Shenavai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Dilly","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus-Liebig University, Frankfurter Strasse 106, D-35392 Giessen, Germany 1Department of Anatomy University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany 2Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine, Uludag University, 16059 G\u00f6r\u00fckle\/Bursa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Pfarrer","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus-Liebig University, Frankfurter Strasse 106, D-35392 Giessen, Germany 1Department of Anatomy University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany 2Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine, Uludag University, 16059 G\u00f6r\u00fckle\/Bursa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6zde R","family":"\u00d6zalp","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus-Liebig University, Frankfurter Strasse 106, D-35392 Giessen, Germany 1Department of Anatomy University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany 2Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine, Uludag University, 16059 G\u00f6r\u00fckle\/Bursa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caglar","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus-Liebig University, Frankfurter Strasse 106, D-35392 Giessen, Germany 1Department of Anatomy University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany 2Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine, Uludag University, 16059 G\u00f6r\u00fckle\/Bursa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Seyrek-Intas","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus-Liebig University, Frankfurter Strasse 106, D-35392 Giessen, Germany 1Department of Anatomy University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany 2Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine, Uludag University, 16059 G\u00f6r\u00fckle\/Bursa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"2026010712530857400_bib1","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.theriogenology.2004.09.008","article-title":"Induction of parturition in the bitch with the progesterone-receptor blocker agl\u00e9pristone","volume":"63","author":"Baan","year":"2005","journal-title":"Theriogenology"},{"key":"2026010712530857400_bib2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-2005-864032","article-title":"Use of the progesterone receptor antagonist RU 486 to identify novel progesterone receptor-regulated pathways in implantation","volume":"23","author":"Bagchi","year":"2005","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712530857400_bib3","first-page":"355","article-title":"The preliminary stage of labor in cattle in relation to the clinical signs of labor and the course of progesterone secretion for the prediction of the calving time","volume":"101","author":"Birgel","year":"1994","journal-title":"Deutsche Tier\u00e4rztliche Wochenschrift"},{"key":"2026010712530857400_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000142118","article-title":"Morphological and histochemical studies on the bovine placenta","volume":"22","author":"Bj\u00f6rkman","year":"1954","journal-title":"Acta Anatomica Supplementum"},{"key":"2026010712530857400_bib5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.theriogenology.2004.12.016","article-title":"Ultrasonographic appearance of the conceptus, fetal heart rate and profiles of pregnancy-associated glycoproteins (PAG) and prostaglandin F2alpha-metabolite (PGF2\u03b1-metabolite) after induction of fetal death with aglepristone during early gestation in cattle","volume":"64","author":"Breukelman","year":"2005","journal-title":"Theriogenology"},{"key":"2026010712530857400_bib6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3168\/jds.S0022-0302(79)83290-7","article-title":"Effects of ovariectomy during pregnancy and of prematurely induced parturition on progesterone, estrogens, and calving traits","volume":"62","author":"Chew","year":"1979","journal-title":"Journal of Dairy Science"},{"key":"2026010712530857400_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1677\/joe.0.0630451","article-title":"Parturition in the cow: endocrine changes in animals with chronically implanted catheters in the foetal and maternal circulations","volume":"63","author":"Comline","year":"1974","journal-title":"Journal of Endocrinology"},{"key":"2026010712530857400_bib8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2527\/jas1987.652500x","article-title":"Effect of prostaglandin F2\u03b1-induced luteolysis on in vivo and in vitro progesterone production by individual placentomes of cows","volume":"65","author":"Conley","year":"1987","journal-title":"Journal of Animal Science"},{"key":"2026010712530857400_bib9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-0897.2005.00364.x","article-title":"Evidence for expression of both classical and non-classical major histocompatibility complex class I genes in bovine trophoblast cells","volume":"55","author":"Davies","year":"2006","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010712530857400_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/00480169.1977.34386","article-title":"Cloprostenol for termination of pregnancy in cattle. B) The induction of abortion","volume":"25","author":"Day","year":"1977","journal-title":"New Zealand Veterinary Journal"},{"key":"2026010712530857400_bib11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/00480169.1977.34385","article-title":"Cloprostenol for termination of pregnancy in cattle. A) The induction of parturition","volume":"25","author":"Day","year":"1977","journal-title":"New Zealand Veterinary Journal"},{"key":"2026010712530857400_bib12","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.2527\/1995.73113421x","article-title":"Mifepristone (RU486) induces parturition in primiparous beef heifers and reduces incidence of dystocia","volume":"73","author":"Dlamini","year":"1995","journal-title":"Journal of Animal Science"},{"key":"2026010712530857400_bib13","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3168\/jds.S0022-0302(67)87615-X","article-title":"Effect of ovariectomy on pregnancy maintenance and parturition in dairy cows","volume":"50","author":"Estergreen","year":"1967","journal-title":"Journal of Dairy Science"},{"key":"2026010712530857400_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1095\/biolreprod30.1.112","article-title":"Failure of exogenous progestogens to block dexamethasone-induced prostaglandin F release from the uterus of the late-pregnant cow","volume":"30","author":"Fairclough","year":"1984","journal-title":"Biology of Reproduction"},{"key":"2026010712530857400_bib15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1095\/biolreprod.108.074336","article-title":"Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle","volume":"81","author":"Forde","year":"2009","journal-title":"Biology of Reproduction"},{"key":"2026010712530857400_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0143-4004(91)90507-C","article-title":"Cellular changes in the peripartum bovine fetal placenta related to placental separation","volume":"12","author":"Gross","year":"1991","journal-title":"Placenta"},{"key":"2026010712530857400_bib17","first-page":"689","article-title":"Zur Problematik polyfaktorieller Krankheitsgeschehen, dargestellt am Beispiel der Retentio secundinarum des Rindes","volume":"127","author":"Grunert","year":"1985","journal-title":"Schweizer Archiv f\u00fcr Tierheilkunde"},{"key":"2026010712530857400_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4142\/jvs.2005.6.1.53","article-title":"Risk factors for retained placenta and the effect of retained placenta on the occurrence of postpartum diseases and subsequent reproductive performance in dairy cows","volume":"6","author":"Han","year":"2005","journal-title":"Journal of Veterinary Science"},{"key":"2026010712530857400_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jcem-60-1-1","article-title":"Increased adrenocorticotropin, cortisol, and arginine vasopressin secretion in primates after the antiglucocorticoid steroid RU 486: dose\u2013response relationships","volume":"60","author":"Healy","year":"1985","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712530857400_bib20"},{"key":"2026010712530857400_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0739-7240(02)00166-2","article-title":"The bovine placenta; a source and target of steroid hormones: observations during the second half of gestation","volume":"23","author":"Hoffmann","year":"2002","journal-title":"Domestic Animal Endocrinology"},{"key":"2026010712530857400_bib22","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000178317","article-title":"An efficient procedure for the determination of progesterone by radioimmunoassay applied to bovine peripheral plasma","volume":"4","author":"Hoffmann","year":"1973","journal-title":"Hormone Research"},{"key":"2026010712530857400_bib23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1095\/biolreprod15.1.126","article-title":"Free and conjugated steroids in maternal and fetal plasma in the cow near term","volume":"15","author":"Hoffmann","year":"1976","journal-title":"Biology of Reproduction"},{"key":"2026010712530857400_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0378-4320(79)90051-4","article-title":"Observations concerning the functional status of the corpus luteum and the placenta around parturition in the cow","volume":"2","author":"Hoffmann","year":"1979","journal-title":"Animal Reproduction Science"},{"key":"2026010712530857400_bib26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1530\/jrf.0.0960837","article-title":"Ovarian and pituitary function in dogs after hysterectomy","volume":"96","author":"Hoffmann","year":"1992","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712530857400_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0029-1211280","article-title":"Investigations on hormonal changes around parturition in the dog and the occurrence of pregnancy-specific non conjugated oestrogens","volume":"102","author":"Hoffmann","year":"1994","journal-title":"Experimental and Clinical Endocrinology"},{"key":"2026010712530857400_bib28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1439-0531.1996.tb01444.x","article-title":"Investigations into the course of progesterone-, oestrogen- and eCG-concentrations during normal and impaired pregnancy in the mare","volume":"32","author":"Hoffmann","year":"1996","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712530857400_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1439-0531.1999.tb01244.x","article-title":"Aspects of hormonal control and induced parturition in the dog","volume":"34","author":"Hoffmann","year":"1999","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712530857400_bib30","first-page":"653","article-title":"Foetal and maternal hormonal changes preceding normal bovine parturition","volume":"84","author":"Hunter","year":"1977","journal-title":"Acta Endocrinologica"},{"key":"2026010712530857400_bib31","first-page":"288","article-title":"Termination of pregnancy with cloprostenol and dexamethasone in intact or ovariectomized cows","volume":"22","author":"Johnson","year":"1981","journal-title":"Canadian Veterinary Journal"},{"key":"2026010712530857400_bib32","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1530\/REP-06-0040","article-title":"The glycosylation of pregnancy-associated glycoproteins and prolactin-related protein-I in bovine binucleate trophoblast giant cells changes before parturition","volume":"132","author":"Klisch","year":"2006","journal-title":"Reproduction"},{"key":"2026010712530857400_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1439-0531.2002.00325.x","article-title":"15-Ketodihydro-PGF(2\u03b1), progesterone and uterine involution in primiparous cows with induced retained placenta and post-partal endometritis treated with oxytetracycline and flunixin","volume":"37","author":"K\u00f6nigsson","year":"2002","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712530857400_bib34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0024-3205(96)00698-4","article-title":"Antiprogestins and iatrogenic glucocorticoid resistance","volume":"60","author":"Koper","year":"1997","journal-title":"Life Sciences"},{"key":"2026010712530857400_bib35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.anireprosci.2008.12.011","article-title":"Time related changes in luteal prostaglandin synthesis and steroidogenic capacity during pregnancy, normal and antiprogestin induced luteolysis in the bitch","volume":"116","author":"Kowalewski","year":"2009","journal-title":"Animal Reproduction Science"},{"key":"2026010712530857400_bib36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/jcem-73-1-187","article-title":"The endocrine effects of long-term treatment with mifepristone (RU 486)","volume":"73","author":"Lamberts","year":"1991","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712530857400_bib37","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.2527\/1997.7592526x","article-title":"Body temperature and endocrine interactions before and after calving in beef cows","volume":"75","author":"Lammoglia","year":"1997","journal-title":"Journal of Animal Science"},{"key":"2026010712530857400_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/vr.139.19.465","article-title":"Bovine retained placenta: aetiology, pathogenesis and economic loss","volume":"139","author":"Laven","year":"1996","journal-title":"Veterinary Record"},{"key":"2026010712530857400_bib39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1210\/endo-129-2-765","article-title":"Antiprogesterone RU486 facilitates parturition in cattle","volume":"129","author":"Li","year":"1991","journal-title":"Endocrinology"},{"key":"2026010712530857400_bib40","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/vr.165.21.615","article-title":"Structure and function of the bovine fetomaternal unit in relation to the causes of retained fetal membranes","volume":"165","author":"McNaughton","year":"2009","journal-title":"Veterinary Record"},{"key":"2026010712530857400_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1055\/s-0029-1211281","article-title":"Luteal versus placental progesterone: the situation in the cow, pig and bitch","volume":"102","author":"Meyer","year":"1994","journal-title":"Experimental and Clinical Endocrinology"},{"key":"2026010712530857400_bib42","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.2460\/ajvr.1986.47.09.1967","article-title":"Progesterone secretion by the bovine fetoplacental unit and responsiveness of corpora lutea to steroidogenic stimuli at two stages of gestation","volume":"47","author":"Pimentel","year":"1986","journal-title":"American Journal of Veterinary Research"},{"issue":"Supplement 9","key":"2026010712530857400_bib43","first-page":"75","article-title":"Regulation of progesterone synthesis and action in bovine corpus luteum","volume":"59","author":"Rekawiecki","year":"2008","journal-title":"Journal of Physiology and Pharmacology"},{"key":"2026010712530857400_bib44"},{"key":"2026010712530857400_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0029-1211278","article-title":"Investigations on the use of C-21-steroids as precursors for placental oestrogen synthesis in the cow","volume":"102","author":"Schuler","year":"1994","journal-title":"Experimental and Clinical Endocrinology"},{"key":"2026010712530857400_bib46","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1095\/biolreprod61.3.797","article-title":"Immunolocalization of progesterone receptors in bovine placentomes throughout mid and late gestation and at parturition","volume":"61","author":"Schuler","year":"1999","journal-title":"Biology of Reproduction"},{"key":"2026010712530857400_bib47","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-2008-1042408","article-title":"Placental steroids in cattle: hormones, placental growth factors or by-products of trophoblast giant cell differentiation?","volume":"116","author":"Schuler","year":"2008","journal-title":"Experimental and Clinical Endocrinology and Diabetes"},{"key":"2026010712530857400_bib48","first-page":"53","article-title":"Der Radioimmunotest (RIA), eine hochspezifische, extrem empfindliche quantitative Analysenmethode","volume":"103","author":"Strecker","year":"1979","journal-title":"Chemiker Zeitung"},{"issue":"Supplement 1","key":"2026010712530857400_bib49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/humrep\/9.suppl_1.12","article-title":"History and perspectives of antiprogestins from the chemist's point of view","volume":"9","author":"Teutsch","year":"1994","journal-title":"Human Reproduction"},{"key":"2026010712530857400_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/jrf.0.1020035","article-title":"3\u03b2-Hydroxysteroid dehydrogenase activity and gestagen concentrations in bovine cotyledons and caruncles during gestation and parturition","volume":"102","author":"Tsumagari","year":"1994","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712530857400_bib51","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0093-691X(92)90175-Q","article-title":"The effects of duration of retained placenta on reproduction, milk production, postpartum disease and culling rate","volume":"37","author":"Van Werven","year":"1992","journal-title":"Theriogenology"},{"key":"2026010712530857400_bib52","first-page":"308","article-title":"Postparturient bovine uterine motility; normal and after experimentally produced retention of the fetal membranes","volume":"19","author":"Venable","year":"1958","journal-title":"American Journal of Veterinary Research"},{"key":"2026010712530857400_bib53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1439-0531.1992.tb01124.x","article-title":"Changes in placental hormone secretion after dexamethasone treatment in cattle","volume":"27","author":"Wagner","year":"1992","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712530857400_bib54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/plac.2001.0633","article-title":"Matrix metalloproteinases (MMP-2 and MMP-9) and tissue inhibitor-2 of matrix metalloproteinases (TIMP-2) in the placenta and interplacental uterine wall in normal cows and in cattle with retention of fetal membranes","volume":"22","author":"Walter","year":"2001","journal-title":"Placenta"},{"key":"2026010712530857400_bib55","first-page":"290","article-title":"Retained placenta in the bovine. A brief review","volume":"6","author":"Wetherill","year":"1965","journal-title":"Canadian Veterinary Journal"},{"key":"2026010712530857400_bib56","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1095\/biolreprod64.4.1019","article-title":"Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic\u2013pituitary\u2013adrenal axis activation and intrauterine prostaglandin production","volume":"64","author":"Whittle","year":"2001","journal-title":"Biology of Reproduction"},{"key":"2026010712530857400_bib57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0093-691X(87)90268-8","article-title":"Peripartum changes in the bovine placenta related to fetal membrane retention","volume":"28","author":"Williams","year":"1987","journal-title":"Theriogenology"},{"key":"2026010712530857400_bib58","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1439-0442.1986.tb00578.x","article-title":"Morphologische und funktionelle Aspekte plazentarer Reifungsmechanismen beim Rind","volume":"33","author":"Woicke","year":"1986","journal-title":"Journal of Veterinary Medicine A"},{"key":"2026010712530857400_bib59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ajog.2006.09.005","article-title":"Progesterone withdrawal: key to parturition","volume":"196","author":"Zakar","year":"2007","journal-title":"American Journal of Obstetrics and Gynecology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/140\/4\/623.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/140\/4\/623\/64531453\/623.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/140\/4\/623\/64531453\/623.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:57:54Z","timestamp":1767808674000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/140\/4\/623\/8243246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-10-0182","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,10,1]]},"published":{"date-parts":[[2010,10,1]]}}}