{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:37:54Z","timestamp":1791214674687,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Critical age, weight and body composition have been suggested as necessary correlates of sexual maturity. A genome scan to identify quantitative trait loci (QTL) for age and body weight at first egg (AFE and WFE) was conducted on 912 birds from an F2 broiler\u2013layer cross using 106 microsatellite markers. Without a covariate, QTL for body WFE were detected on chromosomes 2, 4, 8, 27 and Z and a single QTL for AFE was detected on chromosome 2. With AFE as a covariate, additional QTL for body WFE were found on chromosomes 1 and 13, with abdominal fat pad as covariate a QTL for body WFE was found on chromosome 1. With body WFE as covariate, additional QTL for AFE were found on chromosomes 1, 3, 4, 13 and 27. The QTL generally acted additively and there was no evidence for epistasis. Consistent with the original line differences, broiler alleles had positive effects on body WFE and negative effects on AFE, whereas the phenotypic correlation between the two traits was positive. The mapped QTL for body WFE cumulatively accounted for almost half the body weight difference between the chicken lines at puberty. Overlapping QTL for body WFE and body weight to 9 weeks of age indicate that most QTL affecting growth rate also affect body WFE. The co-localisation of QTL for body weight, growth and sexual maturity suggests that body weight and growth rate are closely related to the attainment of sexual maturity and that the genetic determination of growth rate has correlated effects on puberty.<\/jats:p>","DOI":"10.1530\/rep-10-0276","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T22:11:37Z","timestamp":1293055897000},"page":"381-389","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":35,"title":["Overlap of quantitative trait loci for early growth rate, and for body weight and age at onset of sexual maturity in chickens"],"prefix":"10.1093","volume":"141","author":[{"given":"B K","family":"Podisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Knott","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh, Roslin, Midlothian, EH25 9PS, Scotland, UK 1Institute of Evolutionary Biology University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, EH9 3JT, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I C","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Burt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Hocking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"2026010712530906200_bib1","doi-asserted-by":"crossref","first-page":"e8450","DOI":"10.1371\/journal.pone.0008450","article-title":"Age at puberty and the emerging obesity epidemic","volume":"4","author":"Aksglaede","year":"2009","journal-title":"PLoS ONE"},{"key":"2026010712530906200_bib2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K","article-title":"Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages","volume":"14","author":"Almasy","year":"1997","journal-title":"Genetic Epidemiology"},{"key":"2026010712530906200_bib3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2052.2006.01487.x","article-title":"QTLs associated with growth traits and abdominal fat weight and their interactions with gender and hatch in commercial meat-type chickens","volume":"37","author":"Atzmon","year":"2006","journal-title":"Animal Genetics"},{"key":"2026010712530906200_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/REP-09-0568","article-title":"The adverse effects of obesity on conception and implantation","volume":"140","author":"Brewer","year":"2010","journal-title":"Reproduction"},{"key":"2026010712530906200_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/00071668408454863","article-title":"Age, body weight and body composition requirements for the onset of sexual maturity of dwarf and normal chickens","volume":"25","author":"Brody","year":"1984","journal-title":"British Poultry Science"},{"key":"2026010712530906200_bib6","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1210\/endo.142.11.8495","article-title":"Puberty in female mice is not associated with increases in either body fat or leptin","volume":"142","author":"Bronson","year":"2001","journal-title":"Endocrinology"},{"key":"2026010712530906200_bib7","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/ps\/86.7.1460","article-title":"Emergence of the chicken as a model organism: implications for agriculture and biology","volume":"86","author":"Burt","year":"2007","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1101\/gr.528003","article-title":"A global search reveals epistatic interaction between QTL for early growth in the chicken","volume":"13","author":"Carlborg","year":"2003","journal-title":"Genome Research"},{"key":"2026010712530906200_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1017\/S0016672304006779","article-title":"Simultaneous mapping of epistatic QTL in chickens reveals clusters of QTL pairs with similar genetic effects on growth","volume":"83","author":"Carlborg","year":"2004","journal-title":"Genetical Research"},{"key":"2026010712530906200_bib10","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/ps\/86.5.917","article-title":"Effects of photoperiod on ovarian morphology and carcass traits at sexual maturity in pullets","volume":"86","author":"Chen","year":"2007","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2156-11-67","article-title":"Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs","volume":"11","author":"Chiu","year":"2010","journal-title":"BMC Genetics"},{"key":"2026010712530906200_bib12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","article-title":"Empirical threshold values for quantitative trait mapping","volume":"138","author":"Churchill","year":"1994","journal-title":"Genetics"},{"key":"2026010712530906200_bib13","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/ps\/80.10.1397","article-title":"Effect of photoperiod and quantitative feed restriction in a broiler strain on onset of lay in females and onset of semen production in males: a genetic hypothesis","volume":"80","author":"Eitan","year":"2001","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib14"},{"key":"2026010712530906200_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1079\/PNS19940015","article-title":"The right weight: body fat, menarche and fertility","volume":"53","author":"Frisch","year":"1994","journal-title":"Proceedings of the Nutrition Society"},{"key":"2026010712530906200_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.169.3943.397","article-title":"Height and weight at menarche and a hypothesis of critical body weights and adolescent events","volume":"169","author":"Frisch","year":"1970","journal-title":"Science"},{"key":"2026010712530906200_bib17","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0022-3476(83)80379-5","article-title":"Comparisons of fatness in premenarcheal and postmenarcheal girls of the same age","volume":"103","author":"Garn","year":"1983","journal-title":"Journal of Pediatrics"},{"key":"2026010712530906200_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1086\/320103","article-title":"Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4","volume":"68","author":"Goddard","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"2026010712530906200_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0020-711X(94)90190-2","article-title":"Rapidly growing broiler (meat-type) chickens. Their origin and use for comparative studies of the regulation of growth","volume":"26","author":"Griffin","year":"1994","journal-title":"International Journal of Biochemistry"},{"key":"2026010712530906200_bib20","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/genetics\/136.3.1195","article-title":"Mapping quantitative trait loci in crosses between outbred lines using least squares","volume":"136","author":"Haley","year":"1994","journal-title":"Genetics"},{"key":"2026010712530906200_bib21","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1093\/ps\/83.12.2044","article-title":"Roles of body weight and feed intake in ovarian follicular dynamics in broiler breeders at the onset of lay and after a forced molt","volume":"83","author":"Hocking","year":"2004","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/713654904","article-title":"Ovarian follicular dynamics in selected and control (relaxed selection) male- and female-lines of broiler breeders fed ad libitum or on restricted allocations of food","volume":"41","author":"Hocking","year":"2000","journal-title":"British Poultry Science"},{"key":"2026010712530906200_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/00071668708416983","article-title":"Ovarian follicular structure of white leghorns fed ad libitum and dwarf and normal broiler breeders fed ad libitum or restricted until point of lay","volume":"28","author":"Hocking","year":"1987","journal-title":"British Poultry Science"},{"key":"2026010712530906200_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/00071660120109908","article-title":"Effects of low dietary protein and different allocations of food during rearing and restricted feeding after peak rate of lay on egg production, fertility and hatchability in female broiler breeders","volume":"43","author":"Hocking","year":"2002","journal-title":"British Poultry Science"},{"key":"2026010712530906200_bib25","doi-asserted-by":"crossref","first-page":"946","DOI":"10.2527\/jas1981.534946x","article-title":"Genetic and phenotypic relationships between pubertal and growth characteristics of gilts","volume":"53","author":"Hutchens","year":"1981","journal-title":"Journal of Animal Science"},{"key":"2026010712530906200_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0091-3057(94)00251-D","article-title":"Effects of estradiol and tamoxifen on feeding, fattiness, and some endocrine criteria in hypothalamic obese hens","volume":"50","author":"Jaccoby","year":"1995","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"2026010712530906200_bib27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/genetics\/138.3.871","article-title":"Controlling the type I and type II errors in mapping quantitative trait loci","volume":"138","author":"Jansen","year":"1994","journal-title":"Genetics"},{"key":"2026010712530906200_bib28","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1542\/peds.2007-1813F","article-title":"Link between body fat and the timing of puberty","volume":"121","author":"Kaplowitz","year":"2008","journal-title":"Pediatrics"},{"key":"2026010712530906200_bib29","first-page":"739","article-title":"Common genetic influences on BMI and age at menarche","volume":"67","author":"Kaprio","year":"1995","journal-title":"Human Biology"},{"key":"2026010712530906200_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2052.2003.01000.x","article-title":"The twofold difference in adult size between the red junglefowl and White Leghorn chickens is largely explained by a limited number of QTLs","volume":"34","author":"Kerje","year":"2003","journal-title":"Animal Genetics"},{"key":"2026010712530906200_bib58","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/genetics\/156.2.899","article-title":"Multitrait least squares quantitative trait loci detection","volume":"156","author":"Knott","year":"2000","journal-title":"Genetics"},{"key":"2026010712530906200_bib31","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/genetics\/139.3.1421","article-title":"A nonparametric approach for mapping quantitative trait loci","volume":"139","author":"Kruglyak","year":"1995","journal-title":"Genetics"},{"key":"2026010712530906200_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1051\/animres:19650204","article-title":"Maturite sexuelle et apparition doeufs a double jaune et sans coquille. Role du regime lumineux et du niveau alimentaire (Sexual maturity and appearance of double-yolked and shell-less eggs. Role of light treatment and nutritional level)","volume":"14","author":"Lacassag","year":"1965","journal-title":"Annales de Zootechnie"},{"key":"2026010712530906200_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/121.1.185","article-title":"Mapping mendelian factors underlying quantitative traits using RFLP linkage maps","volume":"121","author":"Lander","year":"1989","journal-title":"Genetics"},{"key":"2026010712530906200_bib34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/bib\/1.2.151","article-title":"Farm animal genome databases","volume":"1","author":"Law","year":"2000","journal-title":"Briefings in Bioinformatics"},{"key":"2026010712530906200_bib35","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/ps\/86.5.835","article-title":"Polymorphism of growth-correlated genes associated with fatness and muscle fiber traits in chickens","volume":"86","author":"Lei","year":"2007","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib36","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/bioinformatics\/bth175","article-title":"Simultaneous search for multiple QTL using the global optimization algorithm DIRECT","volume":"20","author":"Ljungberg","year":"2004","journal-title":"Bioinformatics"},{"key":"2026010712530906200_bib37","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1534\/genetics.107.077537","article-title":"The role of epistasis in the manifestation of heterosis: a systems-oriented approach","volume":"177","author":"Melchinger","year":"2007","journal-title":"Genetics"},{"key":"2026010712530906200_bib38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/00071660500158055","article-title":"Mapping of quantitative trait loci affecting organ weights and blood variables in a broiler layer cross","volume":"46","author":"Navarro","year":"2005","journal-title":"British Poultry Science"},{"key":"2026010712530906200_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S001667230700852X","article-title":"Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA\/2 mice","volume":"89","author":"Neuschl","year":"2007","journal-title":"Genetical Research"},{"key":"2026010712530906200_bib40","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/jhered\/esi114","article-title":"High diversity of the chicken growth hormone gene and effects on growth and carcass traits","volume":"96","author":"Nie","year":"2005","journal-title":"Journal of Heredity"},{"key":"2026010712530906200_bib41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.anireprosci.2008.09.017","article-title":"Intra-ovarian growth factors regulating ovarian function in avian species: a review","volume":"111","author":"Onagbesan","year":"2009","journal-title":"Animal Reproduction Science"},{"key":"2026010712530906200_bib42","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1152\/physiolgenomics.00113.2005","article-title":"QTL analysis of body composition and metabolic traits in an intercross between chicken lines divergently selected for growth","volume":"25","author":"Park","year":"2006","journal-title":"Physiological Genomics"},{"key":"2026010712530906200_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ps\/82.2.187","article-title":"Effect of selection for growth on onset of sexual maturity in randombred and growth-selected lines of Japanese quail","volume":"82","author":"Reddish","year":"2003","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ps\/80.1.37","article-title":"Carcass traits, ovarian morphology and egg laying characteristics in early versus late maturing strains of commercial egg-type hens","volume":"80","author":"Robinson","year":"2001","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/S0103-90162005000200003","article-title":"Strategic marker selection to detect quantitative trait loci in chicken","volume":"62","author":"Ruy","year":"2005","journal-title":"Scientia Agricola"},{"key":"2026010712530906200_bib46","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2052.2004.01133.x","article-title":"Genetic mapping of quantitative trait loci affecting body weight, egg character and egg production in F2 intercross chickens","volume":"35","author":"Sasaki","year":"2004","journal-title":"Animal Genetics"},{"key":"2026010712530906200_bib47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2052.2005.01394.x","article-title":"Identification of quantitative trait loci associated with egg quality, egg production, and body weight in an F2 resource population of chickens","volume":"37","author":"Schreiweis","year":"2006","journal-title":"Animal Genetics"},{"key":"2026010712530906200_bib48"},{"key":"2026010712530906200_bib49","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/ps\/81.12.1775","article-title":"Mapping of quantitative trait loci for body weight at three, six, and nine weeks of age in a broiler layer cross","volume":"81","author":"Sewalem","year":"2002","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib50","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.3382\/ps.0632103","article-title":"Minimum weight for the onset of sexual maturity in female chickens: heritability and phenotypic correlations with early growth rate","volume":"63","author":"Soller","year":"1984","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib51","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/ps\/81.7.919","article-title":"Mapping of quantitative trait loci affecting quality and production traits in egg layers","volume":"81","author":"Tuiskula-Haavisto","year":"2002","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib52","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/genetics\/143.2.1013","article-title":"Confidence intervals in QTL mapping by bootstrapping","volume":"143","author":"Visscher","year":"1996","journal-title":"Genetics"},{"key":"2026010712530906200_bib53","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/hdy.2009.129","article-title":"Controlling false positives in the mapping of epistatic QTL","volume":"104","author":"Wei","year":"2009","journal-title":"Heredity"},{"key":"2026010712530906200_bib54","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/ps\/81.8.1109","article-title":"Heterosis of growth and reproductive traits in fowl","volume":"81","author":"Williams","year":"2002","journal-title":"Poultry Science"},{"key":"2026010712530906200_bib55","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/00071669508417821","article-title":"Effect of age and carcase composition on the onset of sexual maturity in quail under normal feeding regimens","volume":"36","author":"Yannakopoulos","year":"1995","journal-title":"British Poultry Science"},{"key":"2026010712530906200_bib56","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/genetics\/136.4.1457","article-title":"Precision mapping of quantitative trait loci","volume":"136","author":"Zeng","year":"1994","journal-title":"Genetics"},{"key":"2026010712530906200_bib57","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/ps\/85.10.1700","article-title":"Genome-wide linkage analysis to identify chromosomal regions affecting phenotypic traits in the chicken. I. Growth and average daily gain","volume":"85","author":"Zhou","year":"2006","journal-title":"Poultry Science"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/141\/3\/381.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/141\/3\/381\/64533145\/381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/141\/3\/381\/64533145\/381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:57:50Z","timestamp":1767808670000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/141\/3\/381\/8243247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,1]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-10-0276","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,3,1]]},"published":{"date-parts":[[2011,3,1]]}}}