{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:17:51Z","timestamp":1767813471473,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Unilateral ovariectomy (ULO) was performed in European sea bass (Dicentrarchus labrax L.) during late pre-vitellogenesis\/early vitellogenesis. Plasma steroid levels and the expression of a suite of potential oogenesis-relevant genes in the ovary, brain, and pituitary were evaluated with the aim of understanding their involvement in the compensatory oocyte development occurring within the remaining ovarian lobe. After 69 days of surgery the remaining ovarian lobe in ULO fish was gravimetrically equivalent to an intact-paired ovary of sham operated, control fish. This compensatory ovarian growth was based on an increased number of early perinucleolar oocytes and mid-late stage vitellogenic follicles without an apparent recruitment of primary oocytes into the secondary growth phase. Plasma steroid levels were similar in ULO and control females at all time points analyzed, suggesting an increased steroid production of the remaining ovarian lobe in hemi-castrated females. Results of the gene expression survey conducted indicate that the signaling pathways mediated by Fsh and Gnrh1 constitute the central axes orchestrating the observed ovarian compensatory growth. In addition, steroid receptors, Star protein, Igfs, and members of the transforming growth factor beta superfamily including anti-Mullerian hormone and bone morphogenetic protein 4 were identified as potentially relevant players within this process, although their specific actions and interactions remain to be established. Our results demonstrate that ULO provides an excellent in vivo model for elucidating the interconnected endocrine and molecular mechanisms controlling oocyte development in European sea bass.<\/jats:p>","DOI":"10.1530\/rep-11-0040","type":"journal-article","created":{"date-parts":[[2011,5,24]],"date-time":"2011-05-24T22:47:50Z","timestamp":1306277270000},"page":"243-253","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Mechanisms of oocyte development in European sea bass (\n                    <i>Dicentrarchus labrax<\/i>\n                    L.): investigations via application of unilateral ovariectomy"],"prefix":"10.1093","volume":"142","author":[{"given":"\u00c1ngel","family":"Garc\u00eda-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda I","family":"S\u00e1nchez-Amaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R","family":"Tyler","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Marina y Acuicultura Instituto de Ciencias Marinas de Andaluc\u00eda (CSIC), Avenida Rep\u00fablica Saharaui 2, 11510 Puerto Real, C\u00e1diz, Spain 1Biosciences University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Prat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2026010712571003400_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1096-4959(01)00363-3","article-title":"Three forms of GnRH in the brain and pituitary of the turbot, Scophthalmus maximus: immunological characterization and seasonal variation","volume":"129","author":"Andersson","year":"2001","journal-title":"Comparative Biochemistry and Physiology Part B"},{"key":"2026010712571003400_bib2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1095-8649.2000.tb02131.x","article-title":"Hormonal regulation of the European sea bass reproductive cycle: an individualized female approach","volume":"56","author":"Asturiano","year":"2000","journal-title":"Journal of Fish Biology"},{"key":"2026010712571003400_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3989\/scimar.2002.66n3273","article-title":"Group-synchronous ovarian development. 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