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When serotonin at concentrations from 1\u200afmol\/l to 1\u200a\u03bcmol\/l was added to modified Tyrode's albumin lactate pyruvate (mTALP) medium, hyperactivation was significantly enhanced. Agonists and antagonists of 5-hydroxytryptamine hydrochloride (5-HT) receptors (5-HT2 and 5-HT4 receptors) were added to the medium. Both 5-HT2 and 5-HT4 receptor agonists significantly enhanced hyperactivation, although the effect was greater than the former. However, both 5-HT2 and 5-HT4 receptor antagonists significantly suppressed serotonin-enhanced hyperactivation, with the former suppressing stimulation by a lower concentration of serotonin than the latter. These results indicate that serotonin enhances hyperactivation via 5-HT2 and\/or 5-HT4 receptors in a dose-dependent manner.<\/jats:p>","DOI":"10.1530\/rep-11-0074","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T01:45:13Z","timestamp":1304991913000},"page":"255-266","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":53,"title":["Serotonin-enhanced hyperactivation of hamster sperm"],"prefix":"10.1093","volume":"142","author":[{"given":"Masakatsu","family":"Fujinoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2026010712573756500_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mce.2009.02.006","article-title":"Nongenomic activation of spermatozoa by steroid hormones: facts and 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