{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:15:04Z","timestamp":1767813304633,"version":"3.49.0"},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Successful maintenance, survival and maturation of gametes rely on bidirectional communication between the gamete and its supporting cells. Before puberty, factors from the gamete and its supporting cells are necessary for spermatogonial stem cell and primordial follicle oocyte maintenance. Following gametogenesis, gametes rely on factors and nutrients secreted by cells of the reproductive tracts, the epididymis and\/or oviduct, to complete maturation. Despite extensive studies on female and male reproduction, many of the molecular mechanisms of germ cell maintenance remain relatively unknown, particularly in marsupial species. We present the first study and characterisation of a novel primary miRNA transcript, pri-miR-16c, in the marsupial, the stripe-faced dunnart. Bioinformatic analysis showed that its predicted processed miRNA \u2013 miR-16c \u2013 is present in a wide range of vertebrates, but not eutherians. In situ hybridisation revealed dunnart pri-miR-16c expression in day 4 (primordial germ cells) and day 7 (oogonia) pouch young, in primary oocytes and follicle cells of primordial follicles but then only in follicle cells of primary, secondary and antral follicles in adult ovaries. In the adult testis, pri-miR-16c transcripts were present in the cytoplasm of spermatogonial cells. The oviduct and the epididymis both showed expression, but not any other somatic tissues examined or conceptuses during early embryonic development. This pattern of expression suggests that pri-miR-16c function may be associated with gamete maintenance, possibly through mechanisms involving RNA transfer, until the zygote enters the uterus at the pronuclear stage.<\/jats:p>","DOI":"10.1530\/rep-11-0208","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T21:04:41Z","timestamp":1312491881000},"page":"539-550","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["A novel marsupial pri-miRNA transcript has a putative role in gamete maintenance and defines a vertebrate miRNA cluster paralogous to the miR-15a\/miR-16-1 cluster"],"prefix":"10.1093","volume":"142","author":[{"given":"Phil Chi Khang","family":"Au","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Frankenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Selwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Familari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"2026010712562294900_bib1","first-page":"2744","article-title":"Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis","volume":"84","author":"Aaltonen","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712562294900_bib2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/mrd.1080420212","article-title":"Bovine oviduct-specific glycoprotein: a potent factor for maintenance of viability and motility of bovine spermatozoa in vitro","volume":"42","author":"Abe","year":"1995","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712562294900_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1600-0463.2005.apm_302.x","article-title":"Spermatogonial stem cells: characteristics and experimental possibilities","volume":"113","author":"Aponte","year":"2005","journal-title":"APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica"},{"key":"2026010712562294900_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/cdd.2009.69","article-title":"miR-15a and miR-16-1 in cancer: discovery, function and future perspectives","volume":"17","author":"Aqeilan","year":"2010","journal-title":"Cell Death and Differentiation"},{"key":"2026010712562294900_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1095\/biolreprod.104.034470","article-title":"Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction","volume":"72","author":"Asquith","year":"2005","journal-title":"Biology of Reproduction"},{"key":"2026010712562294900_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.anireprosci.2007.04.012","article-title":"Expression stability of two housekeeping genes (18S rRNA and G3PDH) during in vitro maturation of follicular oocytes in buffalo (Bubalus bubalis)","volume":"103","author":"Aswal","year":"2008","journal-title":"Animal Reproduction Science"},{"key":"2026010712562294900_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/mrd.20708","article-title":"Identification of novel and known ovary-specific genes including ZP2, in a marsupial, the stripe-faced dunnart","volume":"75","author":"Au","year":"2008","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712562294900_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1530\/REP-09-0203","article-title":"Induced ovulation mimics the time-table of natural development in the stripe-faced dunnart, Sminthopsis macroura and results in the birth of fertile young","volume":"139","author":"Au","year":"2010","journal-title":"Reproduction"},{"key":"2026010712562294900_bib9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mrd.21158","article-title":"Cloning and characterization of a new gene from the PAT protein family, in a marsupial, the stripe-faced dunnart (Sminthopsis macroura)","volume":"77","author":"Au","year":"2010","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712562294900_bib10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1387\/ijdb.072551jb","article-title":"Puzzles of mammalian fertilization \u2013 and beyond","volume":"52","author":"Bedford","year":"2008","journal-title":"International Journal of Developmental Biology"},{"key":"2026010712562294900_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1083\/jcb.74.1.68","article-title":"Spermatogenic cells of the prepuberal mouse. 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