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Animals were killed prepubertally at d25 and as adults at d90. Plasma samples were taken for hormone analysis and ovaries serial sectioned for morphometric analyses. In prepubertal animals, only foetal+postnatal and late postnatal TP resulted in increased body weights, and an increase in transitory, but reduced antral follicle numbers without affecting total follicle populations. Treatment with TP during both foetal+postnatal life resulted in the development of streak ovaries with activated follicles containing oocytes that only progressed to a small antral (smA) stage and inactive uteri. TP exposure during foetal or late postnatal life had no effect upon adult reproductive function or the total follicle population, although there was a reduction in the primordial follicle pool. In contrast, TP treatment during full postnatal life (d1\u201325) resulted in anovulation in adults (d90). These animals were heavier, had a greater ovarian stromal compartment, no differences in follicle thecal cell area, but reduced numbers of anti-Mullerian hormone-positive smA follicles when compared with controls. Significantly reduced uterine weights lead reduced follicle oestradiol production. These results support the concept that androgen programming of adult female reproductive function occurs only during specific time windows in foetal and neonatal life with implications for the development of polycystic ovary syndrome in women.<\/jats:p>","DOI":"10.1530\/rep-11-0239","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T22:09:57Z","timestamp":1319148597000},"page":"21-33","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":66,"title":["Effect of androgen treatment during foetal and\/or neonatal life on ovarian function in prepubertal and adult rats"],"prefix":"10.1093","volume":"143","author":[{"given":"Victoria","family":"Tyndall","sequence":"first","affiliation":[{"name":"MRC Human Reproductive Sciences Unit 2Endocrinology Unit University\/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Broyde","sequence":"additional","affiliation":[{"name":"MRC Human Reproductive Sciences Unit 2Endocrinology Unit University\/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sharpe","sequence":"additional","affiliation":[{"name":"MRC Human Reproductive Sciences Unit 2Endocrinology Unit University\/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Welsh","sequence":"additional","affiliation":[{"name":"MRC Human Reproductive Sciences Unit 2Endocrinology Unit University\/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J","family":"Drake","sequence":"additional","affiliation":[{"name":"MRC Human Reproductive Sciences Unit 2Endocrinology Unit University\/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S","family":"McNeilly","sequence":"additional","affiliation":[{"name":"MRC Human Reproductive Sciences Unit 2Endocrinology Unit University\/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2026010712570418600_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1043-2760(98)00019-8","article-title":"Insights into the development of 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