{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:48:17Z","timestamp":1785422897975,"version":"3.56.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The forkhead transcription factor forkhead box L2 (FOXL2) is expressed in granulosa cells of small and medium follicles in the mouse ovary. Foxl2 female knockout mice exhibit primordial follicle depletion and primary ovarian failure, but evidence from adult female conditional Foxl2 knockout mice suggests that FOXL2 may also play a significant role in maintenance of ovarian differentiation at stages beyond the primordial follicle and initial wave of folliculogenesis. We previously showed that human FOXL2 functions as a transcriptional repressor of several key genes involved in granulosa cell proliferation and differentiation, including steroidogenic acute regulatory protein (STAR), P450aromatase (CYP19A1 (CYP19)), P450scc (CYP11A1 (CYP11A)), and cyclin D2 (CCND2). To elucidate the role of mouse FOXL2, we determined its role in transcriptional regulation in Chinese hamster ovary (CHO) cells and then confirmed our findings in mouse granulosa cells. We found that mouse FOXL2 represses the activities of the mouse Star, Cyp19a1, Cyp11a1 promoters in CHO cells, but may not repress the Ccnd2 promoter, and identified the minimal mouse Star, Cyp19a1, and Cyp11a1 promoter regions responsive to FOXL2 regulation. We then knocked down Foxl2 in mouse granulosa cells using siRNA, which resulted in significantly increased expression levels of mouse Star, Cyp19a1, and Cyp11a1 but not Ccnd2. To increase Foxl2 expression levels, we generated a mouse Foxl2 lentiviral construct and used it to infect mouse granulosa cells. Following lentiviral infection, the expression levels of mouse Star, Cyp19a1, and Cyp11a1, but not Ccnd2, decreased significantly. These data confirm that mouse FOXL2 functions as a transcriptional repressor of key granulosa cell genes that influence ovarian development.<\/jats:p>","DOI":"10.1530\/rep-11-0259","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T02:56:54Z","timestamp":1343703414000},"page":"485-494","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":30,"title":["Mouse forkhead L2 maintains repression of FSH-dependent genes in the granulosa cell"],"prefix":"10.1093","volume":"144","author":[{"given":"Fang-Ting","family":"Kuo","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics\/Gynecology, Center for Fertility and Reproductive Medicine, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA 2David Geffen School of Medicine UCLA, Los Angeles, California 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics\/Gynecology, Center for Fertility and Reproductive Medicine, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA 2David Geffen School of Medicine UCLA, Los Angeles, California 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Bentsi-Barnes","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics\/Gynecology, Center for Fertility and Reproductive Medicine, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA 2David Geffen School of Medicine UCLA, Los Angeles, California 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian M","family":"Barlow","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics\/Gynecology, Center for Fertility and Reproductive Medicine, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA 2David Geffen School of Medicine UCLA, Los Angeles, California 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta D","family":"Pisarska","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility Department of Obstetrics\/Gynecology, Center for Fertility and Reproductive Medicine, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, California 90048, USA 2David Geffen School of Medicine UCLA, Los Angeles, California 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2026010712583217400_bib1","first-page":"878","article-title":"The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone \u03b1-subunit gene in pituitary gonadotropes","volume":"8","author":"Barnhart","year":"1994","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib2","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1002\/pmic.200800084","article-title":"The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive\/concerted modification pathways","volume":"8","author":"Benayoun","year":"2008","journal-title":"Proteomics"},{"key":"2026010712583217400_bib3","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1093\/hmg\/ddn209","article-title":"The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles","volume":"17","author":"Benayoun","year":"2008","journal-title":"Human Molecular Genetics"},{"key":"2026010712583217400_bib4","doi-asserted-by":"crossref","first-page":"e8789","DOI":"10.1371\/journal.pone.0008789","article-title":"Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C&gt;G)","volume":"5","author":"Benayoun","year":"2010","journal-title":"PLoS ONE"},{"key":"2026010712583217400_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.fertnstert.2009.09.050","article-title":"Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2","volume":"94","author":"Bentsi-Barnes","year":"2009","journal-title":"Fertility and Sterility"},{"key":"2026010712583217400_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.fertnstert.2009.09.050","article-title":"Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2","volume":"94","author":"Bentsi-Barnes","year":"2010","journal-title":"Fertility and Sterility"},{"key":"2026010712583217400_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gad.14.2.245","article-title":"A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle","volume":"14","author":"Blixt","year":"2000","journal-title":"Genes and Development"},{"key":"2026010712583217400_bib8","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1074\/jbc.M806676200","article-title":"FoxL2 and Smad3 coordinately regulate follistatin gene transcription","volume":"284","author":"Blount","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712583217400_bib9","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1101\/gad.10.17.2212","article-title":"The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation","volume":"10","author":"Brissette","year":"1996","journal-title":"Genes and Development"},{"key":"2026010712583217400_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2002.0780","article-title":"Forkhead transcription factors: key players in development and metabolism","volume":"250","author":"Carlsson","year":"2002","journal-title":"Developmental Biology"},{"key":"2026010712583217400_bib11","doi-asserted-by":"crossref","first-page":"28314","DOI":"10.1016\/S0021-9258(18)46930-X","article-title":"The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)","volume":"269","author":"Clark","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712583217400_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/84781","article-title":"The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis\/ptosis\/epicanthus inversus syndrome","volume":"27","author":"Crisponi","year":"2001","journal-title":"Nature Genetics"},{"key":"2026010712583217400_bib13","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1242\/dev.128.21.4127","article-title":"The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate","volume":"128","author":"Dottori","year":"2001","journal-title":"Development"},{"key":"2026010712583217400_bib14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1210\/me.2010-0141","article-title":"\u03b2-Catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization","volume":"24","author":"Fan","year":"2010","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib15","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/endo-129-3-1452","article-title":"Regulation of cytochrome P450 aromatase messenger ribonucleic acid and activity by steroids and gonadotropins in rat granulosa cells","volume":"129","author":"Fitzpatrick","year":"1991","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib16","doi-asserted-by":"crossref","first-page":"e14389","DOI":"10.1371\/journal.pone.0014389","article-title":"Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter","volume":"5","author":"Fleming","year":"2010","journal-title":"PLoS ONE"},{"key":"2026010712583217400_bib17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0015-0282(16)60309-6","article-title":"An association among blepharophimosis, resistant ovary syndrome, and true premature menopause","volume":"50","author":"Fraser","year":"1988","journal-title":"Fertility and Sterility"},{"key":"2026010712583217400_bib18","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1210\/mend.14.8.0500","article-title":"Follicle-stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB\/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells","volume":"14","author":"Gonzalez-Robayna","year":"2000","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1210\/edrv-5-1-76","article-title":"Hormonal regulation of the differentiation of cultured ovarian granulosa cells","volume":"5","author":"Hsueh","year":"1984","journal-title":"Endocrine Reviews"},{"key":"2026010712583217400_bib20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.14.2.142","article-title":"Unified nomenclature for the winged helix\/forkhead transcription factors","volume":"14","author":"Kaestner","year":"2000","journal-title":"Genes and Development"},{"key":"2026010712583217400_bib21","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1096\/fj.11-184333","article-title":"Antagonistic regulation of Cyp26b1 by transcription factors SOX9\/SF1 and FOXL2 during gonadal development in mice","volume":"25","author":"Kashimada","year":"2011","journal-title":"FASEB Journal"},{"key":"2026010712583217400_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(96)00539-4","article-title":"Five years on the wings of fork head","volume":"57","author":"Kaufmann","year":"1996","journal-title":"Mechanisms of Development"},{"key":"2026010712583217400_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0022-2836(95)80047-6","article-title":"DNA recognition site analysis of Xenopus winged helix proteins","volume":"248","author":"Kaufmann","year":"1995","journal-title":"Journal of Molecular Biology"},{"key":"2026010712583217400_bib24","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1210\/en.2009-0313","article-title":"Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-\u03b1","volume":"150","author":"Kim","year":"2009","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng0297-201","article-title":"Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility","volume":"15","author":"Kumar","year":"1997","journal-title":"Nature Genetics"},{"key":"2026010712583217400_bib26","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1210\/en.2010-0989","article-title":"Mutant forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation","volume":"152","author":"Kuo","year":"2011","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1210\/me.2008-0324","article-title":"A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone \u03b2 subunit transcription","volume":"23","author":"Lamba","year":"2009","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib28","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbrc.2005.08.184","article-title":"Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis","volume":"336","author":"Lee","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"2026010712583217400_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0168-9525(03)00111-2","article-title":"Fox's in development and disease","volume":"19","author":"Lehmann","year":"2003","journal-title":"Trends in Genetics"},{"key":"2026010712583217400_bib30","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1126\/science.7892608","article-title":"Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis","volume":"267","author":"Lin","year":"1995","journal-title":"Science"},{"key":"2026010712583217400_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1095\/biolreprod35.1.27","article-title":"Synergism between granulosa and theca\u2013interstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries: studies on the two-cell, two-gonadotropin hypothesis using steroid antisera","volume":"35","author":"Liu","year":"1986","journal-title":"Biology of Reproduction"},{"key":"2026010712583217400_bib32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/me.2008-0412","article-title":"FSH and FOXO1 regulate genes in the sterol\/steroid and lipid biosynthetic pathways in granulosa cells","volume":"23","author":"Liu","year":"2009","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib33","doi-asserted-by":"crossref","first-page":"e9477","DOI":"10.1371\/journal.pone.0009477","article-title":"The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity","volume":"5","author":"Marongiu","year":"2010","journal-title":"PLoS ONE"},{"key":"2026010712583217400_bib34","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/endo.143.2.8611","article-title":"Intact follicular maturation and defective luteal function in mice deficient for cyclin- dependent kinase-4","volume":"143","author":"Moons","year":"2002","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1534-5807(02)00401-X","article-title":"The forkhead transcription factor Foxo1 regulates adipocyte differentiation","volume":"4","author":"Nakae","year":"2003","journal-title":"Developmental Cell"},{"key":"2026010712583217400_bib36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/endo.142.1.7862","article-title":"Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor","volume":"142","author":"Nishi","year":"2001","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib37","first-page":"2755","article-title":"The DNA-binding specificity of the hepatocyte nuclear factor 3\/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix","volume":"14","author":"Overdier","year":"1994","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712583217400_bib38","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1074\/jbc.M409486200","article-title":"Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad","volume":"280","author":"Park","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712583217400_bib39","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1210\/me.2009-0375","article-title":"FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells","volume":"24","author":"Park","year":"2010","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib40","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1002\/j.1460-2075.1994.tb06827.x","article-title":"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending","volume":"13","author":"Pierrou","year":"1994","journal-title":"EMBO Journal"},{"key":"2026010712583217400_bib41","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/en.2003-1141","article-title":"Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene","volume":"145","author":"Pisarska","year":"2004","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib42","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.1152\/ajpendo.00534.2009","article-title":"LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity","volume":"299","author":"Pisarska","year":"2010","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"2026010712583217400_bib43","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1210\/en.2010-1041","article-title":"Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology","volume":"152","author":"Pisarska","year":"2011","journal-title":"Endocrinology"},{"key":"2026010712583217400_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1210\/edrv-15-6-725","article-title":"Hormonal control of gene expression in the ovary","volume":"15","author":"Richards","year":"1994","journal-title":"Endocrine Reviews"},{"key":"2026010712583217400_bib45","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI41350","article-title":"The ovary: basic biology and clinical implications","volume":"120","author":"Richards","year":"2010","journal-title":"Journal of Clinical Investigation"},{"key":"2026010712583217400_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0303-7207(98)00168-3","article-title":"Molecular mechanisms of ovulation and luteinization","volume":"145","author":"Richards","year":"1998","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010712583217400_bib47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/dna.1995.14.385","article-title":"Hepatocyte nuclear factor 3 determines the amplitude of the glucocorticoid response of the rat tyrosine aminotransferase gene","volume":"14","author":"Roux","year":"1995","journal-title":"DNA and Cell Biology"},{"key":"2026010712583217400_bib48","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1242\/dev.00969","article-title":"The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance","volume":"131","author":"Schmidt","year":"2004","journal-title":"Development"},{"key":"2026010712583217400_bib49","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1056\/NEJMoa0902542","article-title":"Mutation of FOXL2 in granulosa-cell tumors of the ovary","volume":"360","author":"Shah","year":"2009","journal-title":"New England Journal of Medicine"},{"key":"2026010712583217400_bib50","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/384470a0","article-title":"Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis","volume":"384","author":"Sicinski","year":"1996","journal-title":"Nature"},{"key":"2026010712583217400_bib51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.physiol.63.1.193","article-title":"StAR protein and the regulation of steroid hormone biosynthesis","volume":"63","author":"Stocco","year":"2001","journal-title":"Annual Review of Physiology"},{"key":"2026010712583217400_bib52","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/hmg\/ddh124","article-title":"Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development","volume":"13","author":"Uda","year":"2004","journal-title":"Human Molecular Genetics"},{"key":"2026010712583217400_bib53","first-page":"5667","article-title":"A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein","volume":"12","author":"Ueda","year":"1992","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712583217400_bib54","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2009.11.021","article-title":"Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation","volume":"139","author":"Uhlenhaut","year":"2009","journal-title":"Cell"},{"key":"2026010712583217400_bib55","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1210\/me.2006-0248","article-title":"Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein\/steroidogenic factor 1","volume":"21","author":"Wang","year":"2007","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib56","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1210\/me.2007-0020","article-title":"Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation","volume":"21","author":"Wayne","year":"2007","journal-title":"Molecular Endocrinology"},{"key":"2026010712583217400_bib57","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1097-0177(199711)210:3<305::AID-AJA10>3.0.CO;2-9","article-title":"Hepatocyte nuclear factor-3\u03b2 limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo","volume":"210","author":"Zhou","year":"1997","journal-title":"Developmental Dynamics"},{"key":"2026010712583217400_bib58","first-page":"1020","article-title":"The blepharophimosis, ptosis, and epicanthus inversus syndrome: delineation of two types","volume":"35","author":"Zlotogora","year":"1983","journal-title":"American Journal of Human Genetics"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/144\/4\/485.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/144\/4\/485\/64535045\/485.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/144\/4\/485\/64535045\/485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:07:35Z","timestamp":1767809255000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/144\/4\/485\/8243615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-11-0259","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,10,1]]},"published":{"date-parts":[[2012,10,1]]}}}