{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:33:06Z","timestamp":1791340386081,"version":"4.3.1"},"reference-count":138,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The differentiation of primordial germ cells (PGCs) into functional oocytes is important for the continuation of species. In mammals, PGCs begin to differentiate into oocytes during embryonic development. Oocytes develop in clusters called germ line cysts. During fetal or neonatal development, germ cell cysts break apart into single oocytes that become surrounded by pregranulosa cells to form primordial follicles. During the process of cyst breakdown, a subset of cells in each cyst undergoes cell death with only one-third of the initial number of oocytes surviving to form primordial follicles. The mechanisms that control cyst breakdown, oocyte survival, and follicle assembly are currently under investigation. This review describes the mechanisms that have been implicated in the control of primordial follicle formation, which include programmed cell death regulation, growth factor and other signaling pathways, regulation by transcription factors and hormones, meiotic progression, and changes in cell adhesion. Elucidation of mechanisms leading to formation of the primordial follicle pool will help research efforts in ovarian biology and improve treatments of female infertility, premature ovarian failure, and reproductive cancers.<\/jats:p>","DOI":"10.1530\/rep-11-0299","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T02:55:18Z","timestamp":1320720918000},"page":"139-149","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":226,"title":["Follicular assembly: mechanisms of action"],"prefix":"10.1093","volume":"143","author":[{"given":"Melissa E","family":"Pepling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2026010712555483900_bib1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1210\/endo.141.5.7456","article-title":"The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction","volume":"141","author":"Abel","year":"2000","journal-title":"Endocrinology"},{"key":"2026010712555483900_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/molehr\/gah164","article-title":"Presence of NGF and its receptors in ovaries from human fetuses and adults","volume":"11","author":"Abir","year":"2005","journal-title":"Molecular Human Reproduction"},{"key":"2026010712555483900_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/ddp483","article-title":"Tsc\/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles","volume":"19","author":"Adhikari","year":"2010","journal-title":"Human Molecular Genetics"},{"key":"2026010712555483900_bib4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1101\/gad.9.4.455","article-title":"DNA rearrangements located over 100\u200akb 5\u2032 of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development","volume":"9","author":"Bedell","year":"1995","journal-title":"Genes and Development"},{"key":"2026010712555483900_bib5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/56.2.382","article-title":"Physiological role of the aryl hydrocarbon receptor in mouse ovary development","volume":"56","author":"Benedict","year":"2000","journal-title":"Toxicological Sciences"},{"key":"2026010712555483900_bib6","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1101\/gad.12.9.1304","article-title":"Defects in regulation of apoptosis in caspase-2-deficient mice","volume":"12","author":"Bergeron","year":"1998","journal-title":"Genes and Development"},{"key":"2026010712555483900_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-4827(67)90110-3","article-title":"Oogenesis in the mouse. 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