{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:13:50Z","timestamp":1776258830915,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Homeobox genes encode transcription factors that regulate diverse developmental events. The largest known homeobox gene cluster \u2013 the X-linked mouse reproductive homeobox (Rhox) cluster \u2013 harbors genes whose expression patterns and functions are largely unknown. Here, we report that a member of this cluster, Rhox10, is expressed in male germ cells. Rhox10 is highly transcribed in spermatogonia in vivo and is upregulated in response to the differentiation-inducing agent retinoic acid in vitro. Using a specific RHOX10 antiserum that we generated, we found that RHOX10 protein is selectively expressed in fetal gonocytes, germline stem cells, spermatogonia, and early spermatocytes. RHOX10 protein undergoes a dramatic shift in subcellular localization as germ cells progress from mitotically arrested gonocytes to mitotic spermatogonia and from mitotic spermatogonia to early meiotic spermatocytes, consistent with RHOX10 performing different functions in these stages.<\/jats:p>","DOI":"10.1530\/rep-11-0479","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T23:28:08Z","timestamp":1330990088000},"page":"611-624","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["Dynamic expression pattern and subcellular localization of the\n                    <i>Rhox10<\/i>\n                    homeobox transcription factor during early germ cell development"],"prefix":"10.1093","volume":"143","author":[{"given":"Hye-Won","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina T","family":"Dann","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA 1Department of Chemistry Indiana University, Bloomington, Indiana, USA 2Department of Biology University of Texas at San Antonio, San Antonio, Texas, USA 3Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 4Department of Cell Biology and Biochemistry Texas Tech University Health Science Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R","family":"McCarrey","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA 1Department of Chemistry Indiana University, Bloomington, Indiana, USA 2Department of Biology University of Texas at San Antonio, San Antonio, Texas, USA 3Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 4Department of Cell Biology and Biochemistry Texas Tech University Health Science Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin L","family":"Meistrich","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA 1Department of Chemistry Indiana University, Bloomington, Indiana, USA 2Department of Biology University of Texas at San Antonio, San Antonio, Texas, USA 3Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 4Department of Cell Biology and Biochemistry Texas Tech University Health Science Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail A","family":"Cornwall","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA 1Department of Chemistry Indiana University, Bloomington, Indiana, USA 2Department of Biology University of Texas at San Antonio, San Antonio, Texas, USA 3Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 4Department of Cell Biology and Biochemistry Texas Tech University Health Science Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles F","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"2026010712571605900_bib1","doi-asserted-by":"crossref","first-page":"14976","DOI":"10.1073\/pnas.0807297105","article-title":"Stra8 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