{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:38Z","timestamp":1792521578874,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Serotonin (5-hydroxytryptamine; C10H12N2O (5-HT)) is produced in the CNS and in some cells of peripheral tissues. In the mammalian male reproductive system, both 5-HT and tryptophan hydroxylase (TPH) have been described in Leydig cells of the testis and in principal cells of the caput epididymis. In capacitated hamster sperm, it has been shown that 5-HT promotes the acrosomal reaction. The aim of this work was to explore the existence of components of the serotoninergic system and their relevance in human sperm physiology. We used both immunocytochemistry and western blot to detect serotoninergic markers such as 5-HT, TPH1, MAOA, 5-HT1B, 5-HT3, and 5HTT; HPLC for TPH enzymatic activity; Computer Assisted Semen Analysis assays to measure sperm motility parameters and pharmacological approaches to show the effect of 5-HT in sperm motility and tyrosine phosphorylation was assessed by western blot. We found the presence of serotoninergic markers (5-HT, TPH1, MAOA, 5-HT1B, 5-HT2A, 5-HT3, 5-HTT, and TPH enzymatic activity) in human sperm. In addition, we observed a significant increase in tyrosine phosphorylation and changes in sperm motility after 5-HT treatment. In conclusion, our data demonstrate the existence of components of a serotoninergic system in human sperm and support the notion for a functional role of 5-HT in mammalian sperm physiology, which can be modulated pharmacologically.<\/jats:p>","DOI":"10.1530\/rep-12-0145","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T01:49:44Z","timestamp":1349142584000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":69,"title":["Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility"],"prefix":"10.1093","volume":"144","author":[{"given":"Francisco","family":"Jim\u00e9nez-Trejo","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad de Microscop\u00eda Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico 3Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine and John D Dingell VA Medical Center Research and Development Service, Detroit, Michigan, USA 4Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Cardiol\u00f3gicas Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico, Mexico and 5Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Tapia-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad de Microscop\u00eda Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico 3Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine and John D Dingell VA Medical Center Research and Development Service, Detroit, Michigan, USA 4Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Cardiol\u00f3gicas Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico, Mexico and 5Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cerb\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad de Microscop\u00eda Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico 3Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine and John D Dingell VA Medical Center Research and Development Service, Detroit, Michigan, USA 4Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Cardiol\u00f3gicas Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico, Mexico and 5Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad de Microscop\u00eda Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico 3Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine and John D Dingell VA Medical Center Research and Development Service, Detroit, Michigan, USA 4Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Cardiol\u00f3gicas Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico, Mexico and 5Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Manjarrez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad de Microscop\u00eda Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico 3Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine and John D Dingell VA Medical Center Research and Development Service, Detroit, Michigan, USA 4Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Cardiol\u00f3gicas Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico, Mexico and 5Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Adriana","family":"Mendoza-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad de Microscop\u00eda Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico 3Department of Psychiatry and Behavioral Neurosciences Wayne State University School of Medicine and John D Dingell VA Medical Center Research and Development Service, Detroit, Michigan, USA 4Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Cardiol\u00f3gicas Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico, Mexico and 5Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Picazo","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica and 2Unidad 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