{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:05:25Z","timestamp":1788185125216,"version":"build-2803163510"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":4536,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.bioscientifica.com\/journals\/reuselicencerep\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Telocytes (TCs) have been described in various organs and species (www.telocytes.com) as cells with telopodes (Tps) \u2013 very long cellular extensions with an alternation of thin segments (podomers) and dilated portions (podoms). We examined TCs using electron microscopy (EM), immunohistochemistry (IHC), immunofluorescence (IF), time-lapse videomicroscopy and whole-cell patch voltage clamp. EM showed a three-dimensional network of dichotomous-branching Tps, a labyrinthine system with homocellular and heterocellular junctions. Tps release extracellular vesicles (mean diameter of 160.6\u00b16.9\u200anm in non-pregnant myometrium and 171.6\u00b14.6\u200anm in pregnant myometrium), sending macromolecular signals to neighbouring cells. Comparative measurements (non-pregnant and pregnant myometrium) of podomer thickness revealed values of 81.94\u00b11.77 vs 75.53\u00b11.81\u200anm, while the podoms' diameters were 268.6\u00b18.27 vs 316.38\u00b117.56\u200anm. IHC as well as IF revealed double c-kit and CD34 positive results. Time-lapse videomicroscopy of cell culture showed dynamic interactions between Tps and myocytes. In non-pregnant myometrium, patch-clamp recordings of TCs revealed a hyperpolarisation-activated chloride inward current with calcium dependence and the absence of L-type calcium channels. TCs seem to have no excitable properties similar to the surrounding smooth muscle cells (SMCs). In conclusion, this study shows the presence of TCs as a distinct cell type in human non-pregnant and pregnant myometrium and describes morphometric differences between the two physiological states. In addition, we provide a preliminary in vitro electrophysiological evaluation of the non-pregnant state, suggesting that TCs could influence timing of the contractile activity of SMCs.<\/jats:p>","DOI":"10.1530\/rep-12-0369","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T22:41:08Z","timestamp":1360708868000},"page":"357-370","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":148,"title":["Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium"],"prefix":"10.1093","volume":"145","author":[{"given":"Sanda M","family":"Cretoiu","sequence":"first","affiliation":[{"name":"Division of Cellular and Molecular Medicine , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Departments of Ultrastructural Pathology , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Molecular Medicine Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Anatomy Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Neurological Sciences (DSNNMM) Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Division of Advanced Studies Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Cretoiu","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Medicine , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Departments of Ultrastructural Pathology , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Molecular Medicine Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Anatomy Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Neurological Sciences (DSNNMM) Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Division of Advanced Studies Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Marin","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Medicine , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Departments of Ultrastructural Pathology , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Molecular Medicine Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Anatomy Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Neurological Sciences (DSNNMM) Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Division of Advanced Studies Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice Mihaela","family":"Radu","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Medicine , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Departments of Ultrastructural Pathology , Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania 2"},{"name":"Molecular Medicine Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Department of Anatomy Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , 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Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"},{"name":"Division of Advanced Studies Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania 4 Animal Physiology, and Biophysics, Faculty of Biology, University of Bucharest, Bucharest 050095, Romania 5 , University of Verona, Verona 37134, Italy 6 , Victor Babe\u015f National Institute of Pathology, Bucharest 050096, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2026010712463887200_bib1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1095\/biolreprod.107.066373","article-title":"Uterine contractions depend on KIT-positive interstitial cells in the 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