{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:49:09Z","timestamp":1788328149206,"version":"build-2803163510"},"reference-count":139,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pregnancy in placental mammals offers exceptional comprehensive benefits of in utero protection, nutrition, and metabolic waste elimination for the developing fetus. However, these benefits also require durable strategies to mitigate maternal rejection of fetal tissues expressing foreign paternal antigens. Since the initial postulate of expanded maternal immune tolerance by Sir Peter Medawar 60 years ago, an amazingly elaborate assortment of molecular and cellular modifications acting both locally at the maternal\u2013placental interface and systemically have been shown to silence potentially detrimental maternal immune responses. In turn, simultaneously maintaining host defense against the infinite array of potential pathogens during pregnancy is equally important. Fortunately, resistance against most infections is preserved seamlessly throughout gestation. On the other hand, recent studies on pathogens with unique predisposition for prenatal infections have uncovered distinctive holes in host defense associated with the reproductive process. Using these infections to probe the response during pregnancy, the immune suppressive regulatory subset of maternal CD4 T cells has been increasingly shown to dictate the inter-workings between prenatal infection susceptibility and pathogenesis of ensuing pregnancy complications. Herein, the recent literature suggesting a necessity for maternal regulatory T cells (Tregs) in pregnancy-induced immunological shifts that sustain fetal tolerance is reviewed. Additional discussion is focused on how expansion of maternal Treg suppression may become exploited by pathogens that cause prenatal infections and the perilous potential of infection-induced immune activation that may mitigate fetal tolerance and inadvertently inject hostility into the protective in utero environment.<\/jats:p>","DOI":"10.1530\/rep-13-0262","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T01:20:01Z","timestamp":1376011201000},"page":"R191-R203","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":38,"title":["Regulatory T cells and the immune pathogenesis of prenatal infection"],"prefix":"10.1093","volume":"146","author":[{"given":"Jared H","family":"Rowe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Ertelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Sing","family":"Way","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"2026010712273277800_bib1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/humrep\/del178","article-title":"Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I: C)","volume":"21","author":"Abrahams","year":"2006","journal-title":"Human Reproduction"},{"key":"2026010712273277800_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nature Immunology"},{"key":"2026010712273277800_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fimmu.2012.00113","article-title":"Comparative genomics reveals key gain-of-function events in Foxp3 during regulatory T cell evolution","volume":"3","author":"Andersen","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"2026010712273277800_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-2000-13448","article-title":"Infection and preterm birth","volume":"17","author":"Andrews","year":"2000","journal-title":"American Journal of Perinatology"},{"issue":"Suppl 4","key":"2026010712273277800_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1439-0531.2012.02101.x","article-title":"T-cell tolerance to the developing equine conceptus","volume":"47","author":"Antczak","year":"2012","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712273277800_bib6","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1086\/430090","article-title":"Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection","volume":"191","author":"Bakardjiev","year":"2005","journal-title":"Journal of Infectious Diseases"},{"key":"2026010712273277800_bib7","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1371\/journal.ppat.0020066","article-title":"Listeria monocytogenes traffics from maternal organs to the placenta and back","volume":"2","author":"Bakardjiev","year":"2006","journal-title":"PLoS Pathogens"},{"key":"2026010712273277800_bib8","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1128\/IAI.73.10.6322-6331.2005","article-title":"Th1 cytokines are essential for placental immunity to Listeria monocytogenes","volume":"73","author":"Barber","year":"2005","journal-title":"Infection and Immunity"},{"key":"2026010712273277800_bib9","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/1529-0131(199906)42:6<1219::AID-ANR19>3.0.CO;2-G","article-title":"Does rheumatoid arthritis remit during pregnancy and relapse postpartum? 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