{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:32:49Z","timestamp":1767868369750,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We hypothesised that the expression pattern of members of the fibroblast growth factor (FGF) family would be altered in the endometrium as the oestrous cycle\/early pregnancy progressed associated with changes in the expression pattern of their receptors in the developing embryo\/conceptus. Expression of FGF1 and FGF10 transcript variants 1 and 2 increased significantly as the oestrous cycle\/early pregnancy progressed. Neither progesterone (P4) supplementation nor pregnancy status significantly affected the expression of any of the FGF ligands studied. However, there was a significant interaction between day, pregnancy and P4 status on FGF2 expression (P&amp;lt;0.05) and a significant interaction between P4 status and day on FGF10_tv2 expression. FGF10 protein was localised in the luminal and glandular epithelium as well as the stroma but was not detected in the myometrium. By RNA sequencing, the expression of FGF ligands in the developing embryo\/conceptus was found to be minimal. The expression of FGF receptor 1 (FGFR1), FGFR2, FGFR3, FGFR4, FGFRL1 and FRS3 was significantly affected by the stage of conceptus development. Interestingly, the expression of FGFR1 and FGFR4 was higher during early embryo development (days 7\u201313, P&amp;lt;0.05) but decreased on day 16 (P&amp;lt;0.05) while FGFR2 (P&amp;lt;0.001) expression was similar from day 7 through to day 13, with a significant increase by day 16 (P&amp;lt;0.05) that was maintained until day 19 (P&amp;gt;0.05). In conclusion, these data demonstrate that FGF ligands are primarily expressed by the endometrium and their modulation throughout the luteal phase of the oestrous cycle\/early pregnancy are associated with alterations in the expression of their receptors in the embryo\/conceptus.<\/jats:p>","DOI":"10.1530\/rep-13-0373","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:59:32Z","timestamp":1392857972000},"page":"825-834","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":22,"title":["Temporal regulation of fibroblast growth factors and their receptors in the endometrium and conceptus during the pre-implantation period of pregnancy in cattle"],"prefix":"10.1093","volume":"147","author":[{"given":"L A","family":"Okumu","sequence":"first","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Forde","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mamo","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"McGettigan","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Mehta","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Roche","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lonergan","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science 2"},{"name":"School of Veterinary Medicine 2"},{"name":"Conway Institute of Biomolecular and Biomedical Science \u00a0 University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2026010712273029400_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejogrb.2004.05.014","article-title":"Fibroblast growth factor-10 and fibroblast growth factor receptors 1-4: expression and peptide localization in human decidua and placenta","volume":"119","author":"Anteby","year":"2005","journal-title":"European Journal of Obstetrics Gynecology and Reproductive Biology"},{"key":"2026010712273029400_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1210\/er.2003-0040","article-title":"Fibroblast growth factor signaling during early vertebrate development","volume":"26","author":"Bottcher","year":"2005","journal-title":"Endocrine Reviews"},{"key":"2026010712273029400_bib2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1095\/biolreprod.107.062273","article-title":"Expression and function of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in bovine follicles","volume":"77","author":"Buratini","year":"2007","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1071\/RD07204","article-title":"Effect of increasing progesterone concentration from day 3 of pregnancy on subsequent embryo survival and development in beef heifers","volume":"20","author":"Carter","year":"2008","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712273029400_bib4","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/mrd.20811","article-title":"Expression of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in the bovine corpus luteum","volume":"75","author":"Castilho","year":"2008","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712273029400_bib5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1095\/biolreprod63.3.959","article-title":"Fibroblast growth factor-10: a stromal mediator of epithelial function in the ovine uterus","volume":"63","author":"Chen","year":"2000","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1530\/REP-09-0152","article-title":"Progesterone and conceptus elongation in cattle: a direct effect on the embryo or an indirect effect via the endometrium?","volume":"138","author":"Clemente","year":"2009","journal-title":"Reproduction"},{"key":"2026010712273029400_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1530\/REP-08-0396","article-title":"Several fibroblast growth factors are expressed during pre-attachment bovine conceptus development and regulate interferon-\u03c4 expression from trophectoderm","volume":"137","author":"Cooke","year":"2009","journal-title":"Reproduction"},{"key":"2026010712273029400_bib9","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.theriogenology.2010.12.007","article-title":"Fibroblast growth factor requirements for in vitro development of bovine embryos","volume":"75","author":"Fields","year":"2011","journal-title":"Theriogenology"},{"key":"2026010712273029400_bib10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1095\/biolreprod.108.074336","article-title":"Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle","volume":"81","author":"Forde","year":"2009","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1152\/physiolgenomics.00162.2009","article-title":"Effect of pregnancy and progesterone concentration on expression of genes encoding for transporters or secreted proteins in the bovine endometrium","volume":"41","author":"Forde","year":"2010","journal-title":"Physiological Genomics"},{"key":"2026010712273029400_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1095\/biolreprod.110.085910","article-title":"Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation","volume":"84","author":"Forde","year":"2011","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib13","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1095\/biolreprod56.6.1527","article-title":"Immunolocalization of acidic and basic fibroblast growth factors in porcine uterine and conceptus tissues","volume":"56","author":"Gupta","year":"1997","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00319141","article-title":"Promotion of gastrulation by maternal growth factor in cultured rabbit blastocysts","volume":"282","author":"Hrabe de Angelis","year":"1995","journal-title":"Cell and Tissue Research"},{"key":"2026010712273029400_bib40","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tig.2004.08.007","article-title":"Evolution of the Fgf and Fgfr gene families","volume":"20","author":"Itoh","year":"2004","journal-title":"Trends in Genetics"},{"key":"2026010712273029400_bib15","doi-asserted-by":"crossref","first-page":"10691","DOI":"10.1073\/pnas.89.22.10691","article-title":"Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells","volume":"89","author":"Jackson","year":"1992","journal-title":"PNAS"},{"key":"2026010712273029400_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1095\/biolreprod.106.056309","article-title":"Regulation of expression of fibroblast growth factor 7 in the pig uterus by progesterone and estradiol","volume":"77","author":"Ka","year":"2007","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.125.2.393","article-title":"Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin","volume":"125","author":"Koji","year":"1994","journal-title":"Journal of Cell Biology"},{"key":"2026010712273029400_bib19","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1074\/jbc.274.18.12827","article-title":"Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate","volume":"274","author":"Lu","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712273029400_bib20","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1095\/biolreprod.111.092643","article-title":"RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation","volume":"85","author":"Mamo","year":"2011","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib21","first-page":"1","article-title":"Conceptus\u2013endometrium crosstalk during maternal recognition of pregnancy in cattle","volume":"6","author":"Mamo","year":"2012","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib22","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1210\/en.2006-0234","article-title":"Fibroblast growth factor-2 is expressed by the bovine uterus and stimulates interferon-\u03c4 production in bovine trophectoderm","volume":"147","author":"Michael","year":"2006","journal-title":"Endocrinology"},{"key":"2026010712273029400_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jcp.1041510113","article-title":"Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum\u2013Golgi complex","volume":"151","author":"Mignatti","year":"1992","journal-title":"Journal of Cellular Physiology"},{"key":"2026010712273029400_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.domaniend.2006.12.002","article-title":"Ovine endometrial expression of fibroblast growth factor (FGF) 2 and conceptus expression of FGF receptors during early pregnancy","volume":"34","author":"Ocon-Grove","year":"2008","journal-title":"Domestic Animal Endocrinology"},{"key":"2026010712273029400_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1530\/REP-10-0113","article-title":"The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus","volume":"140","author":"Okumu","year":"2010","journal-title":"Reproduction"},{"key":"2026010712273029400_bib26","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/physiolgenomics.00251.2010","article-title":"Endometrial expression of progesterone induced blocking factor and galectins-1, -3, -9 and -3 binding protein in the luteal phase and early pregnancy in cattle","volume":"43","author":"Okumu","year":"2011","journal-title":"Physiological Genomics"},{"key":"2026010712273029400_bib27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M","article-title":"FGFs, heparan sulfate and FGFRs: complex interactions essential for development","volume":"22","author":"Ornitz","year":"2000","journal-title":"BioEssays"},{"key":"2026010712273029400_bib28","doi-asserted-by":"crossref","first-page":"REVIEWS3005","DOI":"10.1186\/gb-2001-2-3-reviews3005","article-title":"Fibroblast growth factors","volume":"2","author":"Ornitz","year":"2001","journal-title":"Genome Biology"},{"key":"2026010712273029400_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/REP-12-0220","article-title":"The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro","volume":"145","author":"Ozawa","year":"2013","journal-title":"Reproduction"},{"key":"2026010712273029400_bib29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.placenta.2005.06.007","article-title":"Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows","volume":"27","author":"Pfarrer","year":"2006","journal-title":"Placenta"},{"key":"2026010712273029400_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/erc.0.0070165","article-title":"Fibroblast growth factors, their receptors and signaling","volume":"7","author":"Powers","year":"2000","journal-title":"Endocrine-Related Cancer"},{"key":"2026010712273029400_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2026010712273029400_bib32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1095\/biolreprod59.3.491","article-title":"Fibroblast growth factors 1 and 2 in the primate uterus","volume":"59","author":"Samathanam","year":"1998","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib33","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1095\/biolreprod.108.071787","article-title":"Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus","volume":"79","author":"Satterfield","year":"2008","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1098-2795(199805)50:1<54::AID-MRD7>3.0.CO;2-W","article-title":"Paracrine effects of bFGF and KGF on the process of mouse blastocyst implantation","volume":"50","author":"Taniguchi","year":"1998","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712273029400_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/jrf.0.0960141","article-title":"Immunohistochemical localization of basic fibroblast growth factor within the mouse uterus","volume":"96","author":"Wordinger","year":"1992","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712273029400_bib38","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1095\/biolreprod.111.093203","article-title":"Fibroblast growth factor 2 promotes primitive endoderm development in bovine blastocyst outgrowths","volume":"85","author":"Yang","year":"2011","journal-title":"Biology of Reproduction"},{"key":"2026010712273029400_bib39","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1530\/REP-10-0190","article-title":"Fibroblast growth factor 10 enhances bovine oocyte maturation and developmental competence in vitro","volume":"140","author":"Zhang","year":"2010","journal-title":"Reproduction"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/147\/6\/825.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/147\/6\/825\/64130239\/825.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/147\/6\/825\/64130239\/825.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:29:33Z","timestamp":1767806973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/147\/6\/825\/8235831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-13-0373","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,6,1]]},"published":{"date-parts":[[2014,6,1]]}}}