{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:52:59Z","timestamp":1791064379973,"version":"4.1.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The developing fetus requires substantial amounts of fatty acids to support rapid cellular growth and activity. Although the fatty acid composition delivered to the fetus is largely determined by maternal circulating levels, the placenta preferentially transfers physiologically important long-chain polyunsaturated fatty acids (LC-PUFAs), particularly omega-3 (n-3) PUFAs. Maternal dietary supplementation with n-3 PUFAs during pregnancy has been shown to increase gestation length, enhance fetal growth, and reduce the risk of pregnancy complications, although the precise mechanisms governing these effects remain uncertain. Omega-3 PUFAs are involved in several physiological pathways which could account for these effects, including anti-inflammatory, pro-resolving, and anti-oxidative pathways. Recent studies have shown that maternal dietary n-3 PUFA supplementation during rat pregnancy can reduce placental oxidative damage and increase placental levels of pro-resolving mediators, effects associated with enhanced fetal and placental growth. Because several placental disorders, such as intrauterine growth restriction, preeclampsia, and gestational diabetes mellitus, are associated with heightened placental inflammation and oxidative stress, there is considerable interest in the potential for dietary n-3 PUFAs as a therapeutic intervention for these disorders. In this study, we review the impact of dietary n-3 PUFAs on placental function, with particular focus on placental inflammation, inflammatory resolution, and oxidative stress.<\/jats:p>","DOI":"10.1530\/rep-13-0376","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T23:38:33Z","timestamp":1390433913000},"page":"R143-R152","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":118,"title":["Maternal dietary omega-3 fatty acids and placental function"],"prefix":"10.1093","volume":"147","author":[{"given":"Megan L","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2026010712274080600_bib1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.biocel.2012.06.003","article-title":"Mitochondria: omega-3 in the route of mitochondrial reactive oxygen species","volume":"44","author":"Al-Gubory","year":"2012","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"2026010712274080600_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/jp.2010.53","article-title":"Increased cord serum inflammatory markers in small-for-gestational-age neonates","volume":"31","author":"Amarilyo","year":"2011","journal-title":"Journal of Perinatology"},{"key":"2026010712274080600_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0090-6980(98)00048-3","article-title":"Reduced production of PGE2 and PGF2\u03b1 from decidual cell cultures supplemented with n-3 polyunsaturated fatty acids","volume":"56","author":"Arntzen","year":"1998","journal-title":"Prostaglandins & Other Lipid Mediators"},{"key":"2026010712274080600_bib4","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bbalip.2013.01.012","article-title":"cis-9,trans-11 conjugated linoleic acid stimulates expression of angiopoietin like-4 in the placental extravillous trophoblast cells","volume":"1831","author":"Basak","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"key":"2026010712274080600_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.plefa.2012.10.001","article-title":"Effects of fatty acids on angiogenic activity in the placental extravillous trophoblast cells","volume":"88","author":"Basak","year":"2013","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"2026010712274080600_bib6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0022-2275(20)37440-X","article-title":"High polyunsaturated fatty acid, thromboxane A2, and \u03b1-fetoprotein concentrations at the human feto-maternal interface","volume":"38","author":"Benassayag","year":"1997","journal-title":"Journal of Lipid Research"},{"key":"2026010712274080600_bib7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07202","article-title":"Integration of metabolism and inflammation by lipid-activated nuclear receptors","volume":"454","author":"Bensinger","year":"2008","journal-title":"Nature"},{"key":"2026010712274080600_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative stress","volume":"25","author":"Burton","year":"2011","journal-title":"Best Practice & Research. Clinical Obstetrics & Gynaecology"},{"key":"2026010712274080600_bib9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11745-003-1068-y","article-title":"N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic","volume":"38","author":"Calder","year":"2003","journal-title":"Lipids"},{"issue":"Supplement 1","key":"2026010712274080600_bib10","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ejphar.2011.05.085","article-title":"Fatty acids and inflammation: the cutting edge between food and pharma","volume":"668","author":"Calder","year":"2011","journal-title":"European Journal of Pharmacology"},{"key":"2026010712274080600_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0024-3205(98)00267-7","article-title":"Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexanoic acids","volume":"63","author":"Campbell","year":"1998","journal-title":"Life Sciences"},{"key":"2026010712274080600_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0143-4004(98)90081-9","article-title":"Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placenta","volume":"19","author":"Campbell","year":"1998","journal-title":"Placenta"},{"key":"2026010712274080600_bib13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcn\/61.1.56","article-title":"Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure","volume":"61","author":"Christensen","year":"1995","journal-title":"American Journal of Clinical Nutrition"},{"key":"2026010712274080600_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/0260106012437550","article-title":"The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability","volume":"21","author":"Crawford","year":"2012","journal-title":"Nutrition and Health"},{"key":"2026010712274080600_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.plipres.2008.11.001","article-title":"Transport of fatty acids across the human placenta: a review","volume":"48","author":"Duttaroy","year":"2009","journal-title":"Progress in Lipid Research"},{"key":"2026010712274080600_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/ajcn\/73.4.807","article-title":"Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length","volume":"73","author":"Elias","year":"2001","journal-title":"American Journal of Clinical Nutrition"},{"key":"2026010712274080600_bib17","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1017\/S0007114509993746","article-title":"Influence of fish oil or folate supplementation on the time course of plasma redox markers during pregnancy","volume":"103","author":"Franke","year":"2010","journal-title":"British Journal of Nutrition"},{"key":"2026010712274080600_bib18","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1074\/jbc.274.7.3970","article-title":"Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene","volume":"274","author":"Frohnert","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712274080600_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3945\/ajcn.2010.29589","article-title":"Maternal\u2013fetal in vivo transfer of [13C]docosahexaenoic and other fatty acids across the human placenta 12\u200ah after maternal oral intake","volume":"92","author":"Gil-S\u00e1nchez","year":"2010","journal-title":"American Journal of Clinical Nutrition"},{"key":"2026010712274080600_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fgene.2011.00057","article-title":"Mechanisms involved in the selective transfer of long chain polyunsaturated fatty acids to the fetus","volume":"2","author":"Gil-S\u00e1nchez","year":"2011","journal-title":"Frontiers in Genetics"},{"key":"2026010712274080600_bib21","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/sj.ejcn.1602016","article-title":"Effect of placental function on fatty acid requirements during pregnancy","volume":"58","author":"Haggarty","year":"2004","journal-title":"European Journal of Clinical Nutrition"},{"key":"2026010712274080600_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.nutr.012809.104742","article-title":"Fatty acid supply to the human fetus","volume":"30","author":"Haggarty","year":"2010","journal-title":"Annual Review of Nutrition"},{"key":"2026010712274080600_bib23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.clnu.2008.05.010","article-title":"Long-chain polyunsaturated fatty acid (LC-PUFA) transfer across the placenta","volume":"27","author":"Hanebutt","year":"2008","journal-title":"Clinical Nutrition"},{"key":"2026010712274080600_bib24","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/sj.ijo.0801812","article-title":"Transcriptional regulation of uncoupling protein-2 gene expression in L6 myotubes","volume":"25","author":"Hatakeyama","year":"2001","journal-title":"International Journal of Obesity"},{"key":"2026010712274080600_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.plefa.2003.04.009","article-title":"Prostaglandins and the myometrium and cervix","volume":"70","author":"Hertelendy","year":"2004","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"2026010712274080600_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1095\/biolreprod.105.045914","article-title":"Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure","volume":"74","author":"Hewitt","year":"2006","journal-title":"Biology of Reproduction"},{"key":"2026010712274080600_bib26","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1210\/en.2006-0825","article-title":"Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat","volume":"147","author":"Hewitt","year":"2006","journal-title":"Endocrinology"},{"key":"2026010712274080600_bib28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/plac.2001.0628","article-title":"Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placenta","volume":"22","author":"Hoggard","year":"2001","journal-title":"Placenta"},{"key":"2026010712274080600_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/bbrc.1999.0733","article-title":"Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid","volume":"259","author":"Hun","year":"1999","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"2026010712274080600_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-3016.2012.01292.x","article-title":"Effect of n-3 long-chain polyunsaturated fatty acid intake during pregnancy on maternal, infant, and child health outcomes: a systematic review","volume":"26","author":"Imhoff-Kunsch","year":"2012","journal-title":"Paediatric and Perinatal Epidemiology"},{"key":"2026010712274080600_bib31","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0002-9440(10)64849-3","article-title":"Onset of maternal arterial blood flow and placental oxidative stress: a possible factor in human early pregnancy failure","volume":"157","author":"Jauniaux","year":"2000","journal-title":"American Journal of Pathology"},{"key":"2026010712274080600_bib32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/humupd\/dml016","article-title":"Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution","volume":"12","author":"Jauniaux","year":"2006","journal-title":"Human Reproduction Update"},{"key":"2026010712274080600_bib33","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1016\/j.placenta.2010.12.002","article-title":"Review: Effects of PPAR activation in the placenta and the fetus: implications in maternal diabetes","volume":"32","author":"Jawerbaum","year":"2011","journal-title":"Placenta"},{"key":"2026010712274080600_bib34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.placenta.2009.10.004","article-title":"Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (bewo) cells","volume":"30","author":"Johnsen","year":"2009","journal-title":"Placenta"},{"key":"2026010712274080600_bib35","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.placenta.2011.06.009","article-title":"Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8\/SVneo","volume":"32","author":"Johnsen","year":"2011","journal-title":"Placenta"},{"key":"2026010712274080600_bib36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1095\/biolreprod.110.083907","article-title":"Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2","volume":"83","author":"Jones","year":"2010","journal-title":"Biology of Reproduction"},{"key":"2026010712274080600_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1095\/biolreprod.112.103754","article-title":"Maternal dietary omega-3 fatty acid supplementation reduces placental oxidative stress and increases fetal and placental growth in the rat","volume":"88","author":"Jones","year":"2013","journal-title":"Biology of Reproduction"},{"key":"2026010712274080600_bib37","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1194\/jlr.M039842","article-title":"Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta","volume":"54","author":"Jones","year":"2013","journal-title":"Journal of Lipid Research"},{"key":"2026010712274080600_bib39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1530\/REP-13-0282","article-title":"Maternal omega-3 fatty acid intake increases placental labyrinthine antioxidant capacity, but does not protect against fetal growth restriction induced by placental ischemia\u2013reperfusion injury","volume":"146","author":"Jones","year":"2013","journal-title":"Reproduction"},{"key":"2026010712274080600_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10555-012-9401-9","article-title":"The role of the tissue omega-6\/omega-3 fatty acid ratio in regulating tumor angiogenesis","volume":"32","author":"Kang","year":"2013","journal-title":"Cancer Metastasis Review"},{"key":"2026010712274080600_bib41","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1053\/plac.2002.0948","article-title":"Cytokines, prostaglandins and parturition \u2013 a review","volume":"24","author":"Keelan","year":"2003","journal-title":"Placenta"},{"key":"2026010712274080600_bib42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/1933719110373148","article-title":"Preterm birth, infection, and inflammation advances from the study of animal models","volume":"17","author":"Kemp","year":"2010","journal-title":"Reproductive Sciences"},{"key":"2026010712274080600_bib43","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/09513590802653825","article-title":"High resistin and interleukin-6 levels are associated with gestational diabetes mellitus","volume":"25","author":"Kuzmicki","year":"2009","journal-title":"Gynecological Endocrinology"},{"key":"2026010712274080600_bib44","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1447-0756.2009.01079.x","article-title":"Recurrent pregnancy loss: a disease of inflammation and coagulation","volume":"35","author":"Kwak-Kim","year":"2009","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712274080600_bib45","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/ajcn\/84.4.853","article-title":"Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins","volume":"84","author":"Larqu\u00e9","year":"2006","journal-title":"American Journal of Clinical Nutrition"},{"key":"2026010712274080600_bib46","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1017\/S0007114512001481","article-title":"Omega 3 fatty acids, gestation and pregnancy outcomes","volume":"107","author":"Larqu\u00e9","year":"2012","journal-title":"British Journal of Nutrition"},{"key":"2026010712274080600_bib47","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1210\/jcem.86.6.7529","article-title":"Prenatal leptin production: evidence that fetal adipose tissue produces leptin","volume":"86","author":"Lepercq","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712274080600_bib48","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.reprotox.2012.09.009","article-title":"Treatment of lipoxin A4 and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms","volume":"34","author":"Lin","year":"2012","journal-title":"Reproductive Toxicology"},{"key":"2026010712274080600_bib49","first-page":"4298","article-title":"Leptin production and release in the dually in vitro perfused human placenta","volume":"85","author":"Linnemann","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712274080600_bib50","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1210\/jc.2003-032234","article-title":"Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes","volume":"89","author":"Magnusson","year":"2004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712274080600_bib51","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.freeradbiomed.2011.06.022","article-title":"Uncoupling proteins and the control of mitochondrial reactive oxygen species production","volume":"51","author":"Mailloux","year":"2011","journal-title":"Free Radical Biology & Medicine"},{"key":"2026010712274080600_bib52","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.placenta.2013.04.006","article-title":"The inflammatory state of the rat placenta increases in late gestation and is further enhanced by glucocorticoids in the labyrinth zone","volume":"34","author":"Mark","year":"2013","journal-title":"Placenta"},{"key":"2026010712274080600_bib53","first-page":"4","article-title":"Omega-3 fatty acids, inflammation and angiogenesis: nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils","volume":"1","author":"Massaro","year":"2008","journal-title":"Journal of Nutrigenetics and Nutrigenomics"},{"key":"2026010712274080600_bib54","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.mog.0000153361.90653.cb","article-title":"Essential fatty acids and their derivatives","volume":"21","author":"McCowen","year":"2005","journal-title":"Current Opinion in Gastroenterology"},{"key":"2026010712274080600_bib55","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 Is an omega-3 fatty acid receptor mediating potential anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"2026010712274080600_bib56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.annepidem.2007.03.003","article-title":"Diet during pregnancy and risk of preeclampsia or gestational hypertension","volume":"17","author":"Oken","year":"2007","journal-title":"Annals of Epidemiology"},{"key":"2026010712274080600_bib57","first-page":"1459","article-title":"Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion","volume":"130","author":"Parsons","year":"1992","journal-title":"Endocrinology"},{"key":"2026010712274080600_bib58","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.2174\/138161210793797933","article-title":"Pro-inflammatory cytokines in animal and human gestation","volume":"16","author":"Paulesu","year":"2010","journal-title":"Current Pharmaceutical Design"},{"key":"2026010712274080600_bib59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1479-828X.2006.00532.x","article-title":"Endogenous anti-oxidants in pregnancy and preeclampsia","volume":"46","author":"Perkins","year":"2006","journal-title":"Australian & New Zealand Journal of Obstetrics & Gynaecology"},{"key":"2026010712274080600_bib60","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20070111","article-title":"Maternal fish oil supplementation in pregnancy modifies neonatal leukotriene production by cord-blood-derived neutrophils","volume":"113","author":"Prescott","year":"2007","journal-title":"Clinical Science"},{"key":"2026010712274080600_bib61","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fimmu.2012.00298","article-title":"Pro-resolving lipid mediators (SPMs) and their actions in regulating miRNA in novel resolution circuits in inflammation","volume":"3","author":"Recchiuti","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"2026010712274080600_bib62","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1021\/bi000314z","article-title":"Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions","volume":"39","author":"Richieri","year":"2000","journal-title":"Biochemistry"},{"key":"2026010712274080600_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.phrs.2012.12.003","article-title":"DHA supplementation: current implications in pregnancy and childhood","volume":"70","author":"Rogers","year":"2013","journal-title":"Pharmacological Research"},{"key":"2026010712274080600_bib64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00281-007-0071-6","article-title":"Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia","volume":"29","author":"Rusterholz","year":"2007","journal-title":"Seminars in Immunopathology"},{"key":"2026010712274080600_bib65","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.coph.2010.02.005","article-title":"Lipoxins: regulators of resolution","volume":"10","author":"Ryan","year":"2010","journal-title":"Current Opinion in Pharmacology"},{"key":"2026010712274080600_bib66","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/BJ20031340","article-title":"Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins","volume":"382","author":"Schachtrup","year":"2004","journal-title":"Biochemical Journal"},{"key":"2026010712274080600_bib67","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/en.2007-0211","article-title":"Ligand-activated peroxisome proliferator activated receptor \u03b3 alters placental morphology and placental fatty acid uptake in mice","volume":"148","author":"Schaiff","year":"2007","journal-title":"Endocrinology"},{"key":"2026010712274080600_bib68","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.earlhumdev.2009.02.003","article-title":"Effect of docosahexaenoic acid on oxidative stress in placental trophoblast cells","volume":"85","author":"Shoji","year":"2009","journal-title":"Early Human Development"},{"key":"2026010712274080600_bib69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000327785","article-title":"Importance of the omega-6\/omega-3 balance in health and disease: evolutionary aspects of diet","volume":"102","author":"Simopoulos","year":"2011","journal-title":"World Review of Nutrition and Dietetics"},{"key":"2026010712274080600_bib70","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.placenta.2012.09.010","article-title":"Localisation and characterisation of uncoupling protein-2 (UCP2) in the human preterm placenta","volume":"33","author":"Stark","year":"2012","journal-title":"Placenta"},{"key":"2026010712274080600_bib71","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1530\/REP-13-0239","article-title":"Differential effects of docosahexanoic acid (DHA) on preterm and term placental pro-oxidant\/anti-oxidant balance","volume":"146","author":"Stark","year":"2013","journal-title":"Reproduction"},{"key":"2026010712274080600_bib72","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1210\/en.2007-1682","article-title":"Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism","volume":"149","author":"Umekawa","year":"2008","journal-title":"Endocrinology"},{"key":"2026010712274080600_bib73","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1210\/en.2012-2045","article-title":"New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation","volume":"154","author":"Vandevyver","year":"2013","journal-title":"Endocrinology"},{"key":"2026010712274080600_bib74","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.plefa.2012.12.002","article-title":"Maternal micronutrients and omega 3 fatty acids affect placental fatty acid desaturases and transport proteins in Wistar rats","volume":"88","author":"Wadhwani","year":"2013","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"2026010712274080600_bib75"},{"key":"2026010712274080600_bib76","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mce.2005.05.003","article-title":"Directional secretion and transport of leptin and expression of leptin receptor isoforms in human placental BeWo cells","volume":"241","author":"Wyrwoll","year":"2005","journal-title":"Molecular and Cellular Endocrinology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/147\/5\/R143.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/147\/5\/R143\/64132054\/r143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/147\/5\/R143\/64132054\/r143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:29:56Z","timestamp":1767806996000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/147\/5\/R143\/8235841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,1]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-13-0376","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,5,1]]},"published":{"date-parts":[[2014,5,1]]}}}