{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:28:50Z","timestamp":1789612130120,"version":"build-2803163510"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study assessed the effect of melatonin deprival on ovarian status and function in sheep. Experimental procedures were carried out within two consecutive breeding seasons. Animals were divided into two groups: pinealectomised (n=6) and sham-operated (n=6). The completeness of the pineal gland removal was confirmed by the plasma concentration of melatonin. Ovarian status was monitored by ovarian ultrasonography for 1 year to study reproductive seasonality. Follicular and corpus luteal growth dynamics were assessed during an induced oestrous cycle. As the effects of melatonin on the ovary may also be mediated by its antioxidant properties, plasma Trolox equivalent antioxidant capacity (TEAC) was determined monthly for 1 year. Pinealectomy significantly extended the breeding season (310\u00b124.7 vs 217.5\u00b124.7 days in controls; P&amp;lt;0.05). Both pinealectomised and sham-operated ewes showed a well-defined wave-like pattern of follicle dynamics; however, melatonin deficiency caused fewer waves during the oestrous cycle (4.3\u00b10.2 vs 5.2\u00b10.2; P&amp;lt;0.05), because waves were 1 day longer when compared with the controls (7.2\u00b10.3 vs 6.1\u00b10.3; P&amp;lt;0.05). The mean area of the corpora lutea (105.4\u00b15.9 vs 65.4\u00b15.9\u200amm2; P&amp;lt;0.05) and plasma progesterone levels (7.1\u00b10.7 vs 4.9\u00b10.6\u200ang\/ml; P&amp;lt;0.05) were significantly higher in sham-operated ewes compared with pinealectomised ewes. In addition, TEAC values were significantly lower in pinealectomised ewes compared with control ones. These data suggest that melatonin, besides exerting its well-known role in the synchronisation of seasonal reproductive fluctuations, influences the growth pattern of the follicles and the steroidogenic capacity of the corpus luteum.<\/jats:p>\n                  <jats:p>Free Italian abstract<\/jats:p>\n                  <jats:p>An Italian translation of this abstract is freely available at http:\/\/www.reproduction-online.org\/content\/147\/6\/885\/suppl\/DC1.<\/jats:p>","DOI":"10.1530\/rep-13-0405","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:34:14Z","timestamp":1393374854000},"page":"885-895","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":25,"title":["Melatonin deprival modifies follicular and corpus luteal growth dynamics in a sheep model"],"prefix":"10.1093","volume":"147","author":[{"given":"Maria Elena","family":"Manca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Manunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Spezzigu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Embryo Sardegna \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Department of Animal Reproduction \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Institut National de la Recherche Agronomique (INRA) \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"CNRS \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Torres-Rovira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gonzalez-Bulnes","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Embryo Sardegna \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Department of Animal Reproduction \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Institut National de la Recherche Agronomique (INRA) \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"CNRS \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pasciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Piu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni G","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Succu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Chesneau","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Embryo Sardegna \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Department of Animal Reproduction \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"Institut National de la Recherche Agronomique (INRA) \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"},{"name":"CNRS \u00a0 University of Sassari, Via Vienna 2, 07100 Sassari, Italy 1 \u00a0 Technology, Reproduction, and Fertility, 07034 Perfugas, Localit\u00e0 Suiles (SS), Italy 2 \u00a0 INIA, Avda. Puerta de Hierro s\/n, 28040 Madrid, Spain 3 \u00a0 UMR85, F-37380 Nouzilly, France 4 \u00a0 UMR 7247, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, F-37041 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Naitana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Berlinguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2026010712271409000_bib1"},{"key":"2026010712271409000_bib2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tox.2006.09.018","article-title":"Melatonin has dose-dependent effects on folliculogenesis, oocyte maturation capacity and 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