{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:23:15Z","timestamp":1785806595853,"version":"3.56.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been known for over 3 decades that progesterone (P4) suppresses follicle growth. It has been assumed that P4 acts directly on granulosa cells of developing follicles to slow their development, as P4 inhibits both mitosis and apoptosis of cultured granulosa cells. However, granulosa cells of developing follicles of mice, rats, monkeys, and humans do not express the A or B isoform of the classic nuclear receptor for P4 (PGR). By contrast, these granulosa cells express other P4 binding proteins, one of which is referred to as PGR membrane component 1 (PGRMC1). PGRMC1 specifically binds P4 with high affinity and mediates P4's anti-mitotic and anti-apoptotic action as evidenced by the lack of these P4-dependent effects in PGRMC1-depleted cells. In addition, mice in which PGRMC1 is conditionally depleted in granulosa cells show diminished follicle development. While the mechanism through which P4 activation of PGRMC1 affects granulosa cell function is not well defined, it appears that PGRMC1 controls granulosa cell function in part by regulating gene expression in T-cell-specific transcription factor\/lymphoid enhancer factor-dependent manner. Clinically, altered PGRMC1 expression has been correlated with premature ovarian failure\/insufficiency, polycystic ovarian syndrome, and infertility. These collective studies provide strong evidence that PGRMC1 functions as a receptor for P4 in granulosa cells and that altered expression results in compromised reproductive capacity. Ongoing studies seek to define the components of the signal transduction cascade through which P4 activation of PGRMC1 results in the regulation of granulosa cell function.<\/jats:p>","DOI":"10.1530\/rep-13-0582","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T23:52:03Z","timestamp":1392076323000},"page":"R169-R178","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":75,"title":["Non-canonical progesterone signaling in granulosa cell function"],"prefix":"10.1093","volume":"147","author":[{"given":"John J","family":"Peluso","sequence":"first","affiliation":[{"name":"Departments of Cell Biology"},{"name":"Obstetrics and Gynecology \u00a0 University of Connecticut Health Center, Farmington, Connecticut 06030, USA 3"},{"name":"The Center for Reproductive Biology \u00a0 University of Connecticut Health Center, Farmington, Connecticut 06030, USA 3"},{"name":"Department of Animal Science \u00a0 Washington State University, Pullman, Washington 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K","family":"Pru","sequence":"additional","affiliation":[{"name":"Departments of Cell Biology"},{"name":"Obstetrics and Gynecology \u00a0 University of Connecticut Health Center, Farmington, Connecticut 06030, USA 3"},{"name":"The Center for Reproductive Biology \u00a0 University of Connecticut Health Center, Farmington, Connecticut 06030, USA 3"},{"name":"Department of Animal Science \u00a0 Washington State University, Pullman, Washington 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2026010712271859800_bib1","first-page":"569","article-title":"New data concerning the role played by progesterone in the control of follicular growth in the rat","volume":"75","author":"Buffler","year":"1974","journal-title":"Acta Endocrinologica"},{"key":"2026010712271859800_bib2","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1210\/endo-94-6-1704","article-title":"Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17\u03b2 throughout the 4-day estrous cycle of the rat","volume":"94","author":"Butcher","year":"1974","journal-title":"Endocrinology"},{"key":"2026010712271859800_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jsbmb.2007.02.002","article-title":"Progesterone receptor membrane component 1: an integrative review","volume":"105","author":"Cahill","year":"2007","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"2026010712271859800_bib4","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1210\/en.2005-0759","article-title":"Expression and regulation of progestin membrane receptors in the rat corpus luteum","volume":"146","author":"Cai","year":"2005","journal-title":"Endocrinology"},{"key":"2026010712271859800_bib5","first-page":"1404","article-title":"Progesterone as an autocrine\/paracrine regulator of human granulosa cell proliferation","volume":"75","author":"Chaffkin","year":"1992","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712271859800_bib6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1210\/jcem-73-3-584","article-title":"Titrating luteinizing hormone surge requirements for ovulatory changes in primate follicle. 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