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The role of poly(ADP-ribose)polymerase-1 (PARP1) in apoptosis is well established. However, it is also involved in cell differentiation, proliferation and tissue remodelling. Previous studies have described the presence of PARP in the uterus, but its exact role in embryo implantation is not yet elucidated. Hence, in this study, we studied the expression of PARP1 in the uterus during embryo implantation and decidualisation, and its regulation by ovarian steroids. Our results show upregulation of the native form of PARP1 (\u223c116\u200akDa) in the cytosolic and nuclear compartments of implantation and non-implantation sites at day 5 (0500\u200ah), followed by downregulation at day 5 (1000\u200ah), during the embryo implantation period. The transcript level of Parp1 was also augmented during day 5 (0500\u200ah). Inhibition of PARP1 activity by the drug EB-47 decreased the number of embryo implantation sites and blastocysts at day 5 (1000\u200ah). Further, cleavage of native PARP1 was due to the activity of caspase-3 during the peri-implantation stage (day 5 (0500\u200ah)), and is also required for embryo implantation, as inhibition of its activity compromised blastocyst implantation. The native (\u223c116\u200akDa) and cleaved (\u223c89\u200akDa) forms of PARP1 were both elevated during decidualisation of the uterus. Furthermore, the expression level of PARP1 in the uterus was found to be under the control of the hormone oestrogen. Our results clearly demonstrate that PARP1 participates in the process of embryo implantation.<\/jats:p>","DOI":"10.1530\/rep-13-0588","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T23:52:03Z","timestamp":1392076323000},"page":"765-780","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":36,"title":["PARP1 during embryo implantation and its upregulation by oestradiol in mice"],"prefix":"10.1093","volume":"147","author":[{"given":"Anubha","family":"Joshi","sequence":"first","affiliation":[{"name":"Division of Endocrinology \u00a0 Life Science North 111B\/101 2 \u00a0 Preclinical South 201, CSIR-Central Drug Research Institute, B.S. 10\/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India"},{"name":"Division of Pharmacology \u00a0 Life Science North 111B\/101 2 \u00a0 Preclinical South 201, CSIR-Central Drug Research Institute, B.S. 10\/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Mahfooz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology \u00a0 Life Science North 111B\/101 2 \u00a0 Preclinical South 201, CSIR-Central Drug Research Institute, B.S. 10\/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India"},{"name":"Division of Pharmacology \u00a0 Life Science North 111B\/101 2 \u00a0 Preclinical South 201, CSIR-Central Drug Research Institute, B.S. 10\/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet Kumar","family":"Maurya","sequence":"additional","affiliation":[{"name":"Division of Endocrinology \u00a0 Life Science North 111B\/101 2 \u00a0 Preclinical South 201, CSIR-Central Drug Research Institute, B.S. 10\/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India"},{"name":"Division of 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