{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:50:59Z","timestamp":1767851459253,"version":"3.49.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Similar expression to FGF (SEF or IL17RD), is a tumor suppressor and an inhibitor of growth factors as well as of pro-inflammatory cytokine signaling. In this study, we examined the regulation of Sef expression by gonadotropins during ovarian folliculogenesis. In sexually immature mice, in situ hybridization (ISH) localized Sef gene expression to early developing oocytes and granulosa cells (GC) but not to theca cells. Sef was also expressed in mouse ovarian endothelial cells, in the fallopian tube epithelium as well as in adipose tissue venules. SEF protein expression, determined by immunohistochemistry (IHC), correlated well with Sef mRNA expression in GC, while differential expression was noticed in oocytes. High Sef mRNA but undetectable SEF protein levels were observed in the oocytes of primary\/secondary follicles, while an inverse correlation was found in the oocytes of preantral and small antral follicles. Sef mRNA expression dropped after pregnant mare's serum gonadotropin (PMSG) administration, peaked at 6\u20138\u200ah after human chorionic gonadotropin (hCG) treatment, and declined by 12\u200ah after this treatment. ISH and IHC localized the changes to oocytes and mural GC following PMSG treatment, whereas Sef expression increased in mural GC and declined in granulosa\u2013lutein cells upon hCG treatment. The ovarian expression of SEF was confirmed using human samples. ISH localized SEF transcripts to human GC of antral follicles but not to corpora lutea. Furthermore, SEF mRNA was detected in human GC recovered from preovulatory follicles. These results are the first to demonstrate Sef expression in a healthy ovary during folliculogenesis. Hormonal regulation of its expression suggests that Sef may be an important factor involved in intra-ovarian control mechanisms.<\/jats:p>","DOI":"10.1530\/rep-14-0070","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T15:07:57Z","timestamp":1409238477000},"page":"507-517","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["Expression and regulation of the tumor suppressor, SEF, during folliculogenesis in humans and mice"],"prefix":"10.1093","volume":"148","author":[{"given":"Ela","family":"Lutwak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Biology \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Department of Biological Regulation \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"IVF Unit \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagit-Sela","family":"Abramovich","sequence":"additional","affiliation":[{"name":"Department of Biology \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Department of Biological Regulation \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"IVF Unit \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiri","family":"Rabinovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Granot","sequence":"additional","affiliation":[{"name":"Department of Biology \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Department of Biological Regulation \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"IVF Unit \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nava","family":"Dekel","sequence":"additional","affiliation":[{"name":"Department of Biology \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"Department of Biological Regulation \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, Israel"},{"name":"IVF Unit \u00a0 Technion, Israel Institute of Technology, 32000 Haifa, Israel 1 \u00a0 Centre de Recherche en Reproduction Animale, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Quebec, Canada 2 \u00a0 The Weizmann Institute of Science, Rehovot, Israel 3 \u00a0 Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Rehovot, 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