{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:05Z","timestamp":1789456025271,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nursing supports neonatal porcine uterine and testicular development, however, lactocrine effects on cervical development are undefined. Studies were conducted to determine the effects of i) age and the imposition of the lactocrine-null state from birth (postnatal day 0 (PND0)) by milk replacer feeding on cervical histology; ii) imposition of the lactocrine-null state for 2 days from birth on cervical cell proliferation, as reflected by proliferating cell nuclear antigen immunostaining; and iii) a single feeding of colostrum or milk replacer, administered at birth, with or without oral IGF1, on cervical cell proliferation and phosphorylated AKT (pAKT) and B-cell lymphoma 2 (BCL2) protein levels at 12\u200ah postnatal. Cervical crypt depth and height of luminal epithelium (LE) increased with age by PND14, when both responses were reduced in replacer-fed gilts. Cell proliferation was reduced in LE at PND2, and in crypt epithelium and stroma by PND14 in replacer-fed gilts. Returning replacer-fed gilts to nursing on PND2 did not rescue the cervical phenotype by PND14. A single feeding of colostrum, but not milk replacer, was sufficient to support cervical cell proliferation at 12\u200ah postnatal. IGF1 supplementation induced cell proliferation in replacer-fed gilts, and increased cervical pAKT and BCL2 levels in colostrum-fed gilts and replacer-fed gilts at 12\u200ah postnatal. Results indicate that age and nursing support porcine cervical development, support is initiated at first ingestion of colostrum, IGF1 may be lactocrine-active, and identification of lactocrine-active factors can be accomplished by 12\u200ah postnatal using this bioassay system.<\/jats:p>","DOI":"10.1530\/rep-14-0257","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T21:11:09Z","timestamp":1406668269000},"page":"441-451","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":19,"title":["Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development"],"prefix":"10.1093","volume":"148","author":[{"given":"Meredith E","family":"Camp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne A","family":"Wiley","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 Endocrinology and Animal Biosciences Program, Rutgers University, Foran Hall, 59 Dudley Road, New Brunswick, New Jersey 08901, USA 1 \u00a0 Physiology and Pharmacology, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama 36849, USA"},{"name":"Department of Anatomy \u00a0 Endocrinology and Animal Biosciences Program, Rutgers University, Foran Hall, 59 Dudley Road, New Brunswick, New Jersey 08901, USA 1 \u00a0 Physiology and Pharmacology, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama 36849, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica B","family":"Boulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F","family":"Bartol","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 Endocrinology and Animal Biosciences Program, Rutgers University, Foran Hall, 59 Dudley Road, New Brunswick, New Jersey 08901, USA 1 \u00a0 Physiology and Pharmacology, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama 36849, USA"},{"name":"Department of Anatomy \u00a0 Endocrinology and Animal Biosciences Program, Rutgers University, Foran Hall, 59 Dudley Road, New Brunswick, New Jersey 08901, USA 1 \u00a0 Physiology and Pharmacology, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama 36849, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A","family":"Bagnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"2026010712295598800_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mce.2011.10.008","article-title":"Lactocrine programming of female reproductive tract development: environmental connections to the reproductive continuum","volume":"354","author":"Bartol","year":"2012","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010712295598800_bib2","first-page":"99","article-title":"Early uterine development in pigs","volume":"48","author":"Bartol","year":"1993","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712295598800_bib3","first-page":"287","article-title":"Uterine differentiation as a foundation for subsequent fertility","volume":"54","author":"Bartol","year":"1999","journal-title":"Journal of Reproduction and Fertility"},{"issue":"Suppl 2","key":"2026010712295598800_bib4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1439-0531.2008.01174.x","article-title":"Epigenetic programming of porcine endometrial function and the lactocrine hypothesis","volume":"43","author":"Bartol","year":"2008","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712295598800_bib5","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2527\/jas.2012-5764","article-title":"Lactation Biology Symposium: lactocrine signaling and developmental programming","volume":"91","author":"Bartol","year":"2013","journal-title":"Journal of Animal Science"},{"key":"2026010712295598800_bib6","first-page":"47","article-title":"Cell cycle and growth control","volume":"3","author":"Baserga","year":"1993","journal-title":"Critical Reviews in Eukaryotic Gene Expression"},{"key":"2026010712295598800_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0301-6226(93)90181-G","article-title":"Secretion of insulin-like growth-factors in milk and their effect on the neonate","volume":"35","author":"Baumrucker","year":"1993","journal-title":"Livestock Production Science"},{"key":"2026010712295598800_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0305-0491(88)90137-X","article-title":"The insulin-like growth factors and their binding proteins","volume":"91","author":"Baxter","year":"1988","journal-title":"Comparative Biochemistry and Physiology. B, Comparative Biochemistry"},{"key":"2026010712295598800_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1651-2227.1991.tb17983.x","article-title":"Insulin-like growth factor (IGF) binding proteins: the role of serum IGFBPs in regulating IGF availability","volume":"372","author":"Baxter","year":"1991","journal-title":"Acta Paediatrica Scandinavica. Supplement"},{"key":"2026010712295598800_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-0-387-74087-4_16","article-title":"Insulin-like growth factors (IGFs), IGF binding proteins, and other endocrine factors in milk: role in the newborn","volume":"606","author":"Blum","year":"2008","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"2026010712295598800_bib11","first-page":"R1085","article-title":"Orally administered IGF-I increases intestinal mucosal growth in formula-fed neonatal pigs","volume":"270","author":"Burrin","year":"1996","journal-title":"American Journal of Physiology"},{"key":"2026010712295598800_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1677\/joe.0.1200021","article-title":"Insulin-like growth factor-I and its association with binding proteins in bovine milk","volume":"120","author":"Campbell","year":"1989","journal-title":"Journal of Endocrinology"},{"key":"2026010712295598800_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1095\/biolreprod.111.097188","article-title":"Brief exposure to progesterone during a critical neonatal window prevents uterine gland formation in mice","volume":"86","author":"Cooke","year":"2012","journal-title":"Biology of Reproduction"},{"key":"2026010712295598800_bib14","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.fertnstert.2008.08.067","article-title":"Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing","volume":"90","author":"Crain","year":"2008","journal-title":"Fertility and Sterility"},{"key":"2026010712295598800_bib15","first-page":"198","article-title":"Regulation of insulin-like growth factor binding proteins in young growing animals by alteration of energy status","volume":"3","author":"Dauncey","year":"1993","journal-title":"Growth Regulation"},{"key":"2026010712295598800_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1203\/00006450-199407001-00013","article-title":"Nutritional modulation of insulin-like growth factor-I expression in early postnatal piglets","volume":"36","author":"Dauncey","year":"1994","journal-title":"Pediatric Research"},{"key":"2026010712295598800_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.nu.14.070194.001051","article-title":"Growth factors in milk as mediators of infant development","volume":"14","author":"Donovan","year":"1994","journal-title":"Annual Review of Nutrition"},{"key":"2026010712295598800_bib18","first-page":"242","article-title":"Insulin-like growth factors I and II and their binding proteins in human milk: effect of heat treatment on IGF and IGF binding protein stability","volume":"13","author":"Donovan","year":"1991","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"2026010712295598800_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1203\/00006450-199101000-00010","article-title":"Insulin-like growth factors I and II and their binding proteins in rat milk","volume":"29","author":"Donovan","year":"1991","journal-title":"Pediatric Research"},{"key":"2026010712295598800_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1203\/00006450-199408000-00005","article-title":"Insulin-like growth factors and insulin-like growth factor binding proteins in porcine serum and milk throughout lactation","volume":"36","author":"Donovan","year":"1994","journal-title":"Pediatric Research"},{"key":"2026010712295598800_bib21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","article-title":"Regulation of neuronal survival by the serine\u2013threonine protein kinase Akt","volume":"275","author":"Dudek","year":"1997","journal-title":"Science"},{"key":"2026010712295598800_bib22","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1210\/endo-125-6-2996","article-title":"Hormonal control of the cervix in pregnant gilts. I. Changes in the physical properties of the cervix correlate temporally with elevated serum levels of estrogen and relaxin","volume":"125","author":"Eldridge-White","year":"1989","journal-title":"Endocrinology"},{"key":"2026010712295598800_bib23","first-page":"141","article-title":"Progesterone inhibits uterine gland development in the neonatal mouse uterus","volume":"146","author":"Filant","year":"2013","journal-title":"Biology of Reproduction"},{"key":"2026010712295598800_bib24","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1210\/en.2006-0349","article-title":"Insulin growth factor-I and epidermal growth factor receptors recruit distinct upstream signaling molecules to enhance AKT activation in mammary epithelial cells","volume":"147","author":"Fleming","year":"2006","journal-title":"Endocrinology"},{"key":"2026010712295598800_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1677\/joe.0.1170183","article-title":"Plasma half-lives of native and modified insulin-like growth factor-I in lambs","volume":"117","author":"Francis","year":"1988","journal-title":"Journal of Endocrinology"},{"key":"2026010712295598800_bib26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1530\/REP-10-0401","article-title":"Characterization and biological activity of relaxin in porcine milk","volume":"141","author":"Frankshun","year":"2011","journal-title":"Reproduction"},{"key":"2026010712295598800_bib27","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1210\/en.2012-1329","article-title":"Nursing during the first two days of life is essential for the expression of proteins important for growth and remodeling of the neonatal porcine cervix","volume":"153","author":"Frankshun","year":"2012","journal-title":"Endocrinology"},{"key":"2026010712295598800_bib28","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1095\/biolreprod64.6.1608","article-title":"Endometrial glands are required for preimplantation conceptus elongation and survival","volume":"64","author":"Gray","year":"2001","journal-title":"Biology of Reproduction"},{"key":"2026010712295598800_bib29","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1095\/biolreprod.103.024992","article-title":"Diethylstilbestrol versus estradiol as neonatal disruptors of the hamster (Mesocricetus auratus) cervix","volume":"70","author":"Hendry","year":"2004","journal-title":"Biology of Reproduction"},{"key":"2026010712295598800_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1203\/00006450-200010000-00013","article-title":"Investigation of three doses of oral insulin-like growth factor-I on jejunal lactase phlorizin hydrolase activity and gene expression and enterocyte proliferation and migration in piglets","volume":"48","author":"Houle","year":"2000","journal-title":"Pediatric Research"},{"key":"2026010712295598800_bib31","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1093\/jn\/131.12.3259","article-title":"Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent","volume":"131","author":"Jensen","year":"2001","journal-title":"Journal of Nutrition"},{"key":"2026010712295598800_bib32","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2527\/jas1987.6451458x","article-title":"Composition of sow milk during lactation","volume":"64","author":"Klobasa","year":"1987","journal-title":"Journal of Animal Science"},{"key":"2026010712295598800_bib33","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jn\/103.5.751","article-title":"Effect of dietary regimen on cessation of uptake of macromolecules by piglet intestinal epithelium (closure) and transport to the blood","volume":"103","author":"Leece","year":"1973","journal-title":"Journal of Nutrition"},{"key":"2026010712295598800_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nn.3596","article-title":"Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory","volume":"17","author":"Liu","year":"2014","journal-title":"Nature Neuroscience"},{"key":"2026010712295598800_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.domaniend.2006.07.002","article-title":"Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin","volume":"33","author":"Masters","year":"2007","journal-title":"Domestic Animal Endocrinology"},{"key":"2026010712295598800_bib36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/endo-129-2-939","article-title":"Insulin-like growth factor (IGF) binding to cell monolayers is directly modulated by the addition of IGF-binding proteins","volume":"129","author":"McCusker","year":"1991","journal-title":"Endocrinology"},{"key":"2026010712295598800_bib37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2011.11.028","article-title":"Environmental signaling and reproduction: a comparative biological and chemical perspective","volume":"354","author":"McLachlan","year":"2012","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010712295598800_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.112.105056","article-title":"Nursing for 48 hours from birth supports porcine uterine gland development and endometrial cell compartment-specific gene expression","volume":"88","author":"Miller","year":"2013","journal-title":"Biology of Reproduction"},{"key":"2026010712295598800_bib39","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1016\/j.febslet.2005.05.040","article-title":"Role of the PDK1\u2013PKB\u2013GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart","volume":"579","author":"Mora","year":"2005","journal-title":"FEBS Letters"},{"key":"2026010712295598800_bib40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000243289","article-title":"Levels of insulin-like growth factor I in full- and preterm human milk in comparison to levels in cow's milk and in milk formulas","volume":"58","author":"Nagashima","year":"1990","journal-title":"Biology of the Neonate"},{"key":"2026010712295598800_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0031-3955(05)70284-4","article-title":"Lactogenesis. The transition from pregnancy to lactation","volume":"48","author":"Neville","year":"2001","journal-title":"Pediatric Clinics of North America"},{"key":"2026010712295598800_bib42","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1677\/joe.0.1700347","article-title":"Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation","volume":"170","author":"Nguyen","year":"2001","journal-title":"Journal of Endocrinology"},{"key":"2026010712295598800_bib43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF02801325","article-title":"Depriving neonatal rats of milk from early lactation has long-term consequences on mammotrope development","volume":"7","author":"Nusser","year":"1997","journal-title":"Endocrine"},{"key":"2026010712295598800_bib44","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/asj.12165","article-title":"Shotgun proteomic analysis of porcine colostrum and mature milk","volume":"85","author":"Ogawa","year":"2014","journal-title":"Animal Science Journal"},{"key":"2026010712295598800_bib45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1023\/A:1022860902083","article-title":"The mammary gland in mammalian evolution: a brief commentary on some of the concepts","volume":"7","author":"Peaker","year":"2002","journal-title":"Journal of Mammary Gland Biology and Neoplasia"},{"key":"2026010712295598800_bib46","first-page":"R1532","article-title":"Growth of artificially fed infant rats: effect of supplementation with insulin-like growth factor I","volume":"272","author":"Philipps","year":"1997","journal-title":"American Journal of Physiology"},{"key":"2026010712295598800_bib47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1677\/joe.0.1260437","article-title":"Increase in milk secretion and mammary blood flow by intra-arterial infusion of insulin-like growth factor-I into the mammary gland of the goat","volume":"126","author":"Prosser","year":"1990","journal-title":"Journal of Endocrinology"},{"key":"2026010712295598800_bib48","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.domaniend.2014.02.006","article-title":"Nursing supports neonatal porcine testicular development","volume":"48","author":"Rahman","year":"2014","journal-title":"Domestic Animal Endocrinology"},{"issue":"Suppl","key":"2026010712295598800_bib49","doi-asserted-by":"crossref","first-page":"E113","DOI":"10.2527\/2006.8413_supplE113x","article-title":"Consequences of birth weight for postnatal growth performance and carcass quality in pigs as related to myogenesis","volume":"84","author":"Rehfeldt","year":"2006","journal-title":"Journal of Animal Science"},{"key":"2026010712295598800_bib50","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1530\/rep.0.1220929","article-title":"Expression of uterine and cervical epithelial cadherin during relaxin-induced growth in pigs","volume":"122","author":"Ryan","year":"2001","journal-title":"Reproduction"},{"key":"2026010712295598800_bib51","first-page":"372","article-title":"Synergy between PI3K\/Akt and Raf\/MEK\/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells","volume":"3","author":"Shelton","year":"2004","journal-title":"Cell Cycle"},{"key":"2026010712295598800_bib52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0012-1606(88)90409-5","article-title":"Maternal and neonatal somatomedin C\/insulin-like growth factor-I (IGF-I) and IGF binding proteins during early lactation in the pig","volume":"130","author":"Simmen","year":"1988","journal-title":"Developmental Biology"},{"key":"2026010712295598800_bib53","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.2527\/1990.68113596x","article-title":"Stimulation by colostrum or mature milk of gastrointestinal tissue development in newborn pigs","volume":"68","author":"Simmen","year":"1990","journal-title":"Journal of Animal Science"},{"key":"2026010712295598800_bib54","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0739-7240(90)90026-V","article-title":"Lactational variation and relationship to postnatal growth of insulin-like growth factor-I in mammary secretions from genetically diverse sows","volume":"7","author":"Simmen","year":"1990","journal-title":"Domestic Animal Endocrinology"},{"key":"2026010712295598800_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0739-7240(01)00106-0","article-title":"Neonatal estradiol exposure alters uterine morphology and endometrial transcriptional activity in prepubertal gilts","volume":"21","author":"Tarleton","year":"2001","journal-title":"Domestic Animal Endocrinology"},{"key":"2026010712295598800_bib56","doi-asserted-by":"crossref","first-page":"31601","DOI":"10.1074\/jbc.M202932200","article-title":"Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin","volume":"277","author":"Tseng","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712295598800_bib57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1079\/BJN19910014","article-title":"Effect of protein deprivation on insulin-like growth factor-binding proteins in rats","volume":"66","author":"Umezawa","year":"1991","journal-title":"British Journal of Nutrition"},{"key":"2026010712295598800_bib58","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tvjl.2012.06.009","article-title":"A simple novel measure of passive transfer of maternal immunoglobulin is predictive of preweaning mortality in piglets","volume":"195","author":"Vallet","year":"2013","journal-title":"Veterinary Journal"},{"key":"2026010712295598800_bib59","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000181103","article-title":"Administration of recombinant human insulin-like growth factor I to pigs: determination of circulating half-lives and chromatographic profiles","volume":"31","author":"Walton","year":"1989","journal-title":"Hormone Research"},{"key":"2026010712295598800_bib60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1210\/endo.133.1.8319559","article-title":"Hormonal control of the cervix in pregnant gilts. IV. Relaxin promotes changes in the histological characteristics of the cervix that are associated with cervical softening during late pregnancy in gilts","volume":"133","author":"Winn","year":"1993","journal-title":"Endocrinology"},{"key":"2026010712295598800_bib61","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ceb.2005.02.010","article-title":"Recent advances in the protein kinase B signaling pathway","volume":"17","author":"Woodgett","year":"2005","journal-title":"Current Opinion in Cell Biology"},{"key":"2026010712295598800_bib62","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1677\/joe.0.1460215","article-title":"Degradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein","volume":"146","author":"Xian","year":"1995","journal-title":"Journal of Endocrinology"},{"key":"2026010712295598800_bib63","first-page":"430","article-title":"Gastrointestinal absorption of insulin like growth factor-I in neonatal pigs","volume":"23","author":"Xu","year":"1996","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"2026010712295598800_bib64","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000244118","article-title":"Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets","volume":"66","author":"Xu","year":"1994","journal-title":"Biology of the Neonate"},{"key":"2026010712295598800_bib65","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1210\/en.2006-0397","article-title":"Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling","volume":"147","author":"Yan","year":"2006","journal-title":"Endocrinology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/148\/4\/441.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/148\/4\/441\/64132400\/441.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/148\/4\/441\/64132400\/441.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:33:33Z","timestamp":1767807213000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/148\/4\/441\/8235977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-14-0257","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,10,1]]},"published":{"date-parts":[[2014,10,1]]}}}