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However, while being highly similar and structurally homologous, a rising amount of evidence is showing that each isoform possesses specific targets as well as preferential subcellular localization. The role of AKT has been studied extensively in reproductive processes, but isoform-specific roles are yet to be fully understood. This review will focus on the role of AKT in the uterus and its function in processes related to cell death and proliferation such as embryo implantation, decidualization, endometriosis, and endometrial cancer in an isoform-centric manner. In this review, we will cover the activation of AKT in various settings, localization of isoforms in subcellular compartments, and the effect of isoform expression on cellular processes. To fully understand the dynamic molecular processes taking place in the uterus, it is crucial that we better understand the physiological role of AKT isoforms as well as their function in the emergence of diseases.<\/jats:p>","DOI":"10.1530\/rep-14-0270","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T15:07:57Z","timestamp":1409238477000},"page":"R85-R95","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":43,"title":["Expression, activation, and role of AKT isoforms in the uterus"],"prefix":"10.1093","volume":"148","author":[{"given":"Fran\u00e7ois","family":"Fabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Asselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"2026010712291165100_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1677\/joe.0.1670085","article-title":"Possible role for protein kinase B in the anti-apoptotic effect of prolactin in rat Nb2 lymphoma cells","volume":"167","author":"Al-Sakkaf","year":"2000","journal-title":"Journal of Endocrinology"},{"key":"2026010712291165100_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bpobgyn.2011.12.007","article-title":"Endometrial cancer","volume":"26","author":"Arora","year":"2012","journal-title":"Best Practice & Research. 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