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Cancer metastasis is facilitated by the remodeling of the extracellular tumor matrix by a family of proteolytic enzymes known as the matrix metalloproteinases (MMPs). There are 23 members of the MMP family, many of which have been reported to be associated with ovarian cancer. In the current paradigm, ovarian tumor cells and the surrounding stromal cells stimulate the synthesis and\/or activation of various MMPs to aid in tumor growth, invasion, and eventual metastasis. The present review sheds light on the different MMPs in the various types of ovarian cancer and on their impact on the progression of this gynecologic malignancy.<\/jats:p>","DOI":"10.1530\/rep-14-0546","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:03:32Z","timestamp":1430168612000},"page":"R55-R64","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":88,"title":["Ovarian cancer: involvement of the matrix metalloproteinases"],"prefix":"10.1093","volume":"150","author":[{"given":"Linah","family":"Al-Alem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas 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