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However, there are no studies on the expression and regulation of KLF5 in the processes of human labour and delivery. Thus, the aims of this study were to determine the effect of i) human labour on KLF5 expression in both foetal membranes and myometrium; ii) the pro-inflammatory cytokine interleukin 1 beta (IL1\u03b2), bacterial product flagellin and the viral dsRNA analogue poly(I:C) on KLF5 expression and iii) KLF5 knockdown by siRNA in human myometrial primary cells on pro-inflammatory and pro-labour mediators. In foetal membranes, there was no effect of term or preterm labour on KLF5 expression. In myometrium, the term labour was associated with an increase in nuclear KLF5 protein expression. Moreover, KLF5 expression was also increased in myometrial cells treated with IL1\u03b2, flagellin or poly(IC), likely factors contributing to preterm birth. KLF5 silencing in myometrial cells significantly decreased IL1\u03b2-induced cytokine expression (IL6 and IL8 mRNA expression and release), COX2 mRNA expression, and subsequent release of prostaglandins PGE2 and PGF2\u03b1. KLF5 silencing also significantly reduced flagellin- and poly(I:C)-induced IL6 and IL8 mRNA expression. Lastly, IL1\u03b2-, flagellin- and poly(I:C)-stimulated NF\u03baB transcriptional activity was significantly suppressed in KLF5-knockout myometrial cells. In conclusion, this study describes novel data in which KLF5 is increased in labouring myometrium, and KLF5 silencing decreased inflammation- and infection-induced pro-labour mediators.<\/jats:p>","DOI":"10.1530\/rep-14-0597","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T22:59:58Z","timestamp":1424127598000},"page":"413-424","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":29,"title":["KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium"],"prefix":"10.1093","volume":"149","author":[{"given":"Martha","family":"Lappas","sequence":"first","affiliation":[{"name":"Mercy Perinatal Research Centre Mercy Hospital for Women, Heidelberg, Victoria, Australia 2 Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4, 163 Studley Road, Heidelberg, Victoria 3084, 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