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Female rats were injected with either equine chorionic gonadotropin (eCG group) to induce folliculogenesis or eCG together with DHEA to induce folliculogenesis in a hyperandrogenic condition (eCG+HA group). The control group was injected with vehicle. Ovarian mRNA levels of the peroxisome proliferator-activated receptor gamma (PPAR\u03b3) co-activator PGC1\u03b1, the PPAR\u03b3 co-repressor NCoR, the main enzymes involved in the ovarian steroidogenesis (CYP17, 3\u03b2-hydroxysteroid dehydrogenase (3\u03b2-HSD), 17\u03b2-HSD, and CYP19A), and cyclooxygenase 2 (COX2) were evaluated only by real-time PCR. COX2 was evaluated by both real-time PCR and western blot. Serum steroid hormones and both the oxidative and inflammatory statuses were also quantified. We found that eCG-induced folliculogenesis induced increased mRNA levels of PGC1\u03b1 and decreased those of NCoR when compared with controls. In addition, we found an increase in serum estradiol (E2) levels and enhanced mRNA expression of CYP19A. A pro-inflammatory status and a pro-oxidant status were also established. When folliculogenesis was induced in a hyperandrogenic condition, the mRNA levels of the PPAR\u03b3 co-repressor NCoR remained higher than in controls and the pro-inflammatory and pro-oxidant statuses were enhanced. In addition, the enzymes involved in ovarian steroidogenesis were altered leading to the accumulation of testosterone and an unfavorable E2\/testosterone ratio. These alterations led to abnormal follicular development.<\/jats:p>","DOI":"10.1530\/rep-15-0041","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T22:33:09Z","timestamp":1426199589000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":13,"title":["Effect of hyperandrogenism on ovarian function"],"prefix":"10.1093","volume":"149","author":[{"given":"Leandro M","family":"Velez","sequence":"first","affiliation":[{"name":"Laboratorio de Fisio-patolog\u00eda Ov\u00e1rica Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"},{"name":"Laboratorio de Endocrinolog\u00eda Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria F","family":"Heber","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisio-patolog\u00eda Ov\u00e1rica Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"},{"name":"Laboratorio de Endocrinolog\u00eda Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana R","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisio-patolog\u00eda Ov\u00e1rica Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"},{"name":"Laboratorio de Endocrinolog\u00eda Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle A","family":"Abruzzese","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisio-patolog\u00eda Ov\u00e1rica Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"},{"name":"Laboratorio de Endocrinolog\u00eda Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana M","family":"Reynoso","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisio-patolog\u00eda Ov\u00e1rica Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"},{"name":"Laboratorio de Endocrinolog\u00eda Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia B","family":"Motta","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisio-patolog\u00eda Ov\u00e1rica Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"},{"name":"Laboratorio de Endocrinolog\u00eda Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 2 Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, 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