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The epididymis is composed of several segments that have distinct gene expression profiles that enable the establishment of the changing luminal environment required for sperm maturation. The epididymal gene expression is regulated by endocrine, lumicrine, and paracrine factors in a segment-specific manner. Thus, in addition to its importance for male fertility, the epididymis is a valuable model tissue for studying the regulation of gene expression. This review concentrates on recent advances in understanding the androgen, small RNA, and epigenetically mediated regulation of segment-specific gene expression in the epididymis.<\/jats:p>","DOI":"10.1530\/rep-15-0533","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T22:30:56Z","timestamp":1464129056000},"page":"R91-R99","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":38,"title":["Segment-specific regulation of epididymal gene expression"],"prefix":"10.1093","volume":"152","author":[{"given":"Petra","family":"Sipil\u00e4","sequence":"first","affiliation":[{"name":"Department of Physiology and Turku Center for Disease Modeling Institute of Biomedicine, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Bj\u00f6rkgren","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology University of 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