{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:12:36Z","timestamp":1793751156362,"version":"4.6.1"},"reference-count":185,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis currently affects ~5.5 million reproductive-aged women in the U.S. with symptoms such as painful periods (dysmenorrhea), chronic pelvic pain, pain with intercourse (dyspareunia), and infertility. It is defined as the presence of endometrial tissue outside the uterine cavity and is found predominately attached to sites within the peritoneal cavity. Diagnosis for endometriosis is solely made through surgery as no consistent biomarkers for disease diagnosis exist. There is no cure for endometriosis and treatments only target symptoms and not the underlying mechanism(s) of disease. The nature of individual predisposing factors or inherent defects in the endometrium, immune system, and\/or peritoneal cavity of women with endometriosis remains unclear. The literature over the last 5 years (2010\u20132015) has advanced our critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer. In this review, we cover the aforementioned topics with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometriosis research, while concluding with critical areas of endometriosis research that are urgently needed.<\/jats:p>","DOI":"10.1530\/rep-16-0052","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T22:51:04Z","timestamp":1462920664000},"page":"R63-R78","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":143,"title":["Endometriosis: where are we and where are we going?"],"prefix":"10.1093","volume":"152","author":[{"given":"Alexis D","family":"Greene","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Cincinnati Center for Reproductive Health, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Kendziorski","sequence":"additional","affiliation":[{"name":"Department of Environmental Health University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M","family":"Sroga-Rios","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Cincinnati Center for Reproductive Health, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Cincinnati Center for Reproductive Health, Cincinnati, Ohio, USA"},{"name":"University of Cincinnati Cancer Institute University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Environmental Health University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2026010712450092400_bib1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2147\/IJWH.S34684","article-title":"Potential role of aromatase inhibitors in the treatment of endometriosis","volume":"6","author":"Abu Hashim","year":"2014","journal-title":"International Journal of Womens Health"},{"key":"2026010712450092400_bib2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000367597","article-title":"Epithelial ovarian cancers and endometriosis","volume":"79","author":"Acien","year":"2015","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"2026010712450092400_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jog.12527","article-title":"Dienogest for the treatment of deep endometriosis: case report and literature review","volume":"41","author":"Agarwal","year":"2015","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712450092400_bib4","first-page":"795976","article-title":"Pathophysiology and immune dysfunction in endometriosis","author":"Ahn","year":"2015","journal-title":"BioMed Research International"},{"key":"2026010712450092400_bib5","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.4049\/jimmunol.1501138","article-title":"IL-17A Contributes to the pathogenesis of endometriosis by triggering proinflammatory cytokines and angiogenic growth factors","volume":"195","author":"Ahn","year":"2015","journal-title":"Journal of Immunology"},{"key":"2026010712450092400_bib6","first-page":"844","article-title":"Prevalence of endometriosis in malignant epithelial ovarian tumor","volume":"18","author":"Akbarzadeh-Jahromi","year":"2015","journal-title":"Archieves of Iranian Medicine"},{"key":"2026010712450092400_bib7","first-page":"107","article-title":"Effect of Letrozole on endometriosis-related pelvic pain","volume":"28","author":"Almassinokiani","year":"2014","journal-title":"Medical Journal of the Islamic Republic of Iran"},{"key":"2026010712450092400_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","author":"American Society for Reproductive Medicine","year":"1997","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib9","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.fertnstert.2011.02.019","article-title":"T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal\/mild endometriosis","volume":"95","author":"Andreoli","year":"2011","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00404-015-3681-6","article-title":"Dienogest in the treatment of endometriosis: systematic review","volume":"292","author":"Andres Mde","year":"2015","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"2026010712450092400_bib11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3109\/09513590.2014.950646","article-title":"New trends of progestins treatment of endometriosis","volume":"30","author":"Angioni","year":"2014","journal-title":"Gynecological Endocrinology"},{"key":"2026010712450092400_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/path.4516","article-title":"Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden","volume":"236","author":"Anglesio","year":"2015","journal-title":"Journal of Pathology"},{"key":"2026010712450092400_bib13","first-page":"220","article-title":"Successful heterotransplantation of human endometrium in SCID mice","volume":"83","author":"Aoki","year":"1994","journal-title":"Obstetrics and Gynecology"},{"key":"2026010712450092400_bib14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1757-2215-3-2","article-title":"Endometriosis-associated ovarian cancer: a ten-year cohort study of women living in the Estrie Region of Quebec, Canada","volume":"3","author":"Aris","year":"2010","journal-title":"Journal of Ovarian Research"},{"key":"2026010712450092400_bib15","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/IGC.0b013e31826b5dcc","article-title":"Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma","volume":"22","author":"Ayhan","year":"2012","journal-title":"International Journal of Gynecological Cancer"},{"key":"2026010712450092400_bib16","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.fertnstert.2012.03.057","article-title":"Peritoneal cytokines and adhesion formation in endometriosis: an inverse association with vascular endothelial growth factor concentration","volume":"97","author":"Barcz","year":"2012","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib17","first-page":"504","article-title":"Prevalence of myofascial chronic pelvic pain and the effectiveness of pelvic floor physical therapy","volume":"58","author":"Bedaiwy","year":"2013","journal-title":"Journal of Reproductive Medicine"},{"key":"2026010712450092400_bib18","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/1933719115585145","article-title":"Abundance and localization of progesterone receptor isoforms in endometrium in women with and without endometriosis and in peritoneal and ovarian endometriotic implants","volume":"22","author":"Bedaiwy","year":"2015","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib19","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.fertnstert.2013.02.038","article-title":"Transcriptional changes in the expression of chemokines related to natural killer and T-regulatory cells in patients with deep infiltrative endometriosis","volume":"99","author":"Bellelis","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3109\/13813455.2012.687003","article-title":"Analysis of cytokines in the peritoneal fluid of endometriosis patients as a function of the menstrual cycle stage using the Bio-Plex(R) platform","volume":"118","author":"Bersinger","year":"2012","journal-title":"Archives of Physiology and Biochemistry"},{"key":"2026010712450092400_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007988","article-title":"Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation","volume":"6","author":"Beste","year":"2014","journal-title":"Science Translational Medicine"},{"key":"2026010712450092400_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1477-7827-12-4","article-title":"Endometriosis and physical exercises: a systematic review","volume":"12","author":"Bonocher","year":"2014","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010712450092400_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fertnstert.2009.02.019","article-title":"Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis","volume":"94","author":"Bourlev","year":"2010","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejogrb.2013.06.001","article-title":"Ovarian carcinoma associated with endometriosis","volume":"170","author":"Boyraz","year":"2013","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"2026010712450092400_bib25","doi-asserted-by":"crossref","first-page":"e62370","DOI":"10.1371\/journal.pone.0062370","article-title":"Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis","volume":"8","author":"Braza-Boils","year":"2013","journal-title":"PLoS ONE"},{"key":"2026010712450092400_bib26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/humrep\/deu019","article-title":"MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors","volume":"29","author":"Braza-Boils","year":"2014","journal-title":"Hum Reproduction"},{"key":"2026010712450092400_bib27","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1093\/humrep\/dev204","article-title":"Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis","volume":"30","author":"Braza-Boils","year":"2015","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0002-9378(97)70550-7","article-title":"Cancer risk after a hospital discharge diagnosis of endometriosis","volume":"176","author":"Brinton","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib29","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1158\/1055-9965.EPI-05-0394","article-title":"Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors","volume":"14","author":"Brinton","year":"2005","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"2026010712450092400_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1001\/jama.2014.17119","article-title":"An overview of treatments for endometriosis","volume":"313","author":"Brown","year":"2015","journal-title":"JAMA"},{"key":"2026010712450092400_bib31","article-title":"Models of endometriosis: animal models I \u2013 rodent-based chimeric models","volume-title":"Endometriosis: Science and Practice.","author":"Bruner-Tran","year":"2012"},{"key":"2026010712450092400_bib32","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1210\/en.2007-0665","article-title":"Inflammatory status influences aromatase and steroid receptor expression in endometriosis","volume":"149","author":"Bukulmez","year":"2008","journal-title":"Endocrinology"},{"key":"2026010712450092400_bib33","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"New England Journal of Medicine"},{"key":"2026010712450092400_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0031-1299596","article-title":"Role of estrogen receptor-beta in endometriosis","volume":"30","author":"Bulun","year":"2012","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712450092400_bib35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1055\/s-0035-1554053","article-title":"Molecular biology of endometriosis: from aromatase to genomic abnormalities","volume":"33","author":"Bulun","year":"2015","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712450092400_bib36","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1210\/en.2006-1692","article-title":"Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis","volume":"148","author":"Burney","year":"2007","journal-title":"Endocrinology"},{"key":"2026010712450092400_bib37","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1210\/en.2012-1294","article-title":"Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model","volume":"153","author":"Burns","year":"2012","journal-title":"Endocrinology"},{"key":"2026010712450092400_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2012.06.001","article-title":"Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6","volume":"95","author":"Carmona","year":"2012","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib39","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3928\/01477447-20090922-11","article-title":"Biologic response to orthopedic sutures: a histologic study in a rabbit model","volume":"32","author":"Carr","year":"2009","journal-title":"Orthopedics"},{"key":"2026010712450092400_bib40","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1177\/1933719114549848","article-title":"Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density","volume":"21","author":"Carr","year":"2014","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib41","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00404-012-2686-7","article-title":"Expression of human beta-defensin-2 in the eutopic and ectopic endometrial tissues in patients with endometriosis.","volume":"287","author":"Chen","year":"2013","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"2026010712450092400_bib42","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.fertnstert.2013.07.1985","article-title":"A tumor necrosis factor-alpha inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid","volume":"100","author":"Chen","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib43","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.fertnstert.2014.03.029","article-title":"Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17beta-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells","volume":"102","author":"Chen","year":"2014","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijgo.2015.02.021","article-title":"The ARID1A pathway in ovarian clear cell and endometrioid carcinoma, contiguous endometriosis, and benign endometriosis","volume":"130","author":"Chene","year":"2015","journal-title":"International Journal of Gynaecology and Obstetrics"},{"key":"2026010712450092400_bib45","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/humrep\/der079","article-title":"Inhibition of steroid sulfatase decreases endometriosis in an in vivo murine model","volume":"26","author":"Colette","year":"2011","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0890-6238(95)00004-T","article-title":"Induction of endometriosis in mice: a new model sensitive to estrogen","volume":"9","author":"Cummings","year":"1995","journal-title":"Reproductive Toxicology"},{"key":"2026010712450092400_bib47","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0015-0282(16)56957-X","article-title":"Development of a model of retrograde menstruation in baboons (Papio anubis)","volume":"62","author":"D\u2019Hooghe","year":"1994","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9378(95)90180-9","article-title":"Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis)","volume":"173","author":"D\u2019Hooghe","year":"1995","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib49","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/00016349609033298","article-title":"The prevalence of spontaneous endometriosis in the baboon (Papio anubis, Papio cynocephalus) increases with the duration of captivity","volume":"75","author":"D\u2019hooghe","year":"1996","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"2026010712450092400_bib50","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/humupd\/dmq031","article-title":"Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain","volume":"16","author":"Daniels","year":"2010","journal-title":"Human Reproduction Update"},{"key":"2026010712450092400_bib51","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ygyno.2014.01.012","article-title":"Comparison of clinical outcomes of patients with clear cell and endometrioid ovarian cancer associated with endometriosis to papillary serous carcinoma of the ovary","volume":"132","author":"Davis","year":"2014","journal-title":"Gynecologic Oncology"},{"key":"2026010712450092400_bib52","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.fertnstert.2013.04.041","article-title":"Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior","volume":"100","author":"Delbandi","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib53","first-page":"CD011031","article-title":"Laparoscopic surgery for endometriosis","volume":"4","author":"Duffy","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"2026010712450092400_bib54","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib55","doi-asserted-by":"crossref","first-page":"e1004158","DOI":"10.1371\/journal.pgen.1004158","article-title":"Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis","volume":"10","author":"Dyson","year":"2014","journal-title":"PLoS Genetics"},{"key":"2026010712450092400_bib56","first-page":"394","article-title":"Frequency of ovarian endometriosis in epithelial ovarian cancer patients","volume":"38","author":"Dzatic-Smiljkovic","year":"2011","journal-title":"Clinical and Experimental Obstetrics & Gynecology"},{"key":"2026010712450092400_bib57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00404-013-2822-z","article-title":"Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis","volume":"288","author":"Elgafor","year":"2013","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"2026010712450092400_bib58","first-page":"19","article-title":"Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain","volume":"11","author":"Ezzati","year":"2015","journal-title":"Womens Health"},{"key":"2026010712450092400_bib59","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.fertnstert.2013.01.097","article-title":"Biomarkers of endometriosis","volume":"99","author":"Fassbender","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib60","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmig.2013.04.017","article-title":"Reliability of visual diagnosis of endometriosis","volume":"20","author":"Fernando","year":"2013","journal-title":"Journal of Minimally Invasive Gynecology"},{"key":"2026010712450092400_bib61","first-page":"CD006568","article-title":"Chinese herbal medicine for endometriosis","volume":"5","author":"Flower","year":"2012","journal-title":"Cochrane Database of Systematic Review"},{"key":"2026010712450092400_bib62","volume-title":"Clinical Gynecologic Endocrinology and Infertility","author":"Fritz","year":"2011"},{"key":"2026010712450092400_bib63","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/aji.12206","article-title":"Expression of natural cytotoxicity receptors on peritoneal fluid natural killer cell and cytokine production by peritoneal fluid natural killer cell in women with endometriosis","volume":"71","author":"Funamizu","year":"2014","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib64","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3109\/09513590.2014.926325","article-title":"Novel insights on the malignant transformation of endometriosis into ovarian carcinoma","volume":"30","author":"Gadducci","year":"2014","journal-title":"Gynecological Endocrinology"},{"key":"2026010712450092400_bib65","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/15680096113139990002","article-title":"Unmet needs in ovarian cancer: dividing histologic subtypes to exploit novel targets and pathways","volume":"13","author":"Galic","year":"2013","journal-title":"Current Cancer Drug Targets"},{"key":"2026010712450092400_bib66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13048-015-0180-0","article-title":"Leptin, its receptor and aromatase expression in deep infiltrating endometriosis","volume":"8","author":"Goncalves","year":"2015","journal-title":"Journal of Ovarian Research"},{"key":"2026010712450092400_bib67","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/aogs.12633","article-title":"Gonadotrophin-releasing hormone analogue or dienogest plus estradiol valerate to prevent pain recurrence after laparoscopic surgery for endometriosis: a multi-center randomized trial","volume":"94","author":"Granese","year":"2015","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"2026010712450092400_bib68","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.ajpath.2014.03.011","article-title":"A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium","volume":"184","author":"Greaves","year":"2014","journal-title":"American Journal of Pathology"},{"key":"2026010712450092400_bib69","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.ajog.2004.02.047","article-title":"Human endometriotic xenografts in immunodeficient RAG-2\/gamma(c)KO mice","volume":"190","author":"Greenberg","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib70","volume-title":"Models of endometriosis: in vitro and in vivo models. In Endometriosis: Science and Practice.","author":"Grummer","year":"2012"},{"key":"2026010712450092400_bib71","first-page":"2011","article-title":"IL-22 in the endometriotic milieu promotes the proliferation of endometrial stromal cells via stimulating the secretion of CCL2 and IL-8","volume":"6","author":"Guo","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"2026010712450092400_bib72","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nm.2826","article-title":"A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis","volume":"18","author":"Han","year":"2012","journal-title":"Nature Medicine"},{"key":"2026010712450092400_bib73","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2015.10.034","article-title":"Estrogen receptor beta modulates apoptosis complexes and the inflammasome to drive the pathogenesis of endometriosis","volume":"163","author":"Han","year":"2015","journal-title":"Cell"},{"key":"2026010712450092400_bib74","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejogrb.2013.03.028","article-title":"Endometriosis, dysmenorrhoea and diet","volume":"169","author":"Hansen","year":"2013","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"2026010712450092400_bib75","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.fertnstert.2007.08.051","article-title":"Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial","volume":"90","author":"Harada","year":"2008","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib76","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jmig.2014.04.002","article-title":"To excise or ablate endometriosis? A prospective randomized double-blinded trial after 5-year follow-up","volume":"21","author":"Healey","year":"2014","journal-title":"Journal of Minimally Invasive Gynecology"},{"key":"2026010712450092400_bib77","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.fertnstert.2010.09.017","article-title":"Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis","volume":"95","author":"Herington","year":"2011","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib78","doi-asserted-by":"crossref","first-page":"g1752","DOI":"10.1136\/bmj.g1752","article-title":"Endometriosis","volume":"348","author":"Hickey","year":"2014","journal-title":"BMJ"},{"key":"2026010712450092400_bib79","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/GRF.0b013e3181db7ce8","article-title":"Invasive and noninvasive methods for the diagnosis of endometriosis","volume":"53","author":"Hsu","year":"2010","journal-title":"Clinical Obstetrics and Gynecology"},{"key":"2026010712450092400_bib80","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/modpathol.2013.216","article-title":"Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma","volume":"27","author":"Huang","year":"2014","journal-title":"Modern Pathology"},{"key":"2026010712450092400_bib81","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.ajpath.2011.11.013","article-title":"Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis","volume":"180","author":"Hull","year":"2012","journal-title":"American Journal of Pathology"},{"key":"2026010712450092400_bib82","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1071\/RD08086","article-title":"Immunohistochemical study of the ubiquitin-nuclear factor-kB pathway in the endometrium of the baboon (Papio anubis) with and without endometriosis","volume":"22","author":"Ilad","year":"2010","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712450092400_bib83","doi-asserted-by":"crossref","first-page":"495","DOI":"10.12891\/ceog17042014","article-title":"Levonorgestrel-releasing intrauterine device used for dysmenorrhea: five-year literature review","volume":"41","author":"Imai","year":"2014","journal-title":"Clinical and Experimental Obstetrics & Gynecology"},{"key":"2026010712450092400_bib84","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.fertnstert.2009.02.052","article-title":"Matrix metalloproteinase messenger RNA expression in human endometriosis grafts cultured on a chicken chorioallantoic membrane","volume":"94","author":"Juhasz-Boss","year":"2010","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib85","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/humrep\/deu172","article-title":"An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression","volume":"29","author":"Kang","year":"2014","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1757-2215-3-3","article-title":"Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes","volume":"3","author":"Keita","year":"2010","journal-title":"Journal of Ovarian Research"},{"key":"2026010712450092400_bib87","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1447-0756.2010.01320.x","article-title":"Endometrioid ovarian cancer and endometriotic cells exhibit the same alteration in the expression of interleukin-1 receptor II: to a link between endometriosis and endometrioid ovarian cancer","volume":"37","author":"Keita","year":"2011","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712450092400_bib88","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/1933719114556487","article-title":"17beta-estradiol and lipopolysaccharide additively promote pelvic inflammation and growth of endometriosis","volume":"22","author":"Khan","year":"2015","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib89","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/bjc.2014.29","article-title":"Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis","volume":"110","author":"Kim","year":"2014","journal-title":"British Journal of Cancer"},{"key":"2026010712450092400_bib90","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/path.4657","article-title":"Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma","volume":"238","author":"King","year":"2016","journal-title":"Journal of Pathology"},{"key":"2026010712450092400_bib91","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.atherosclerosis.2011.08.005","article-title":"Increased asymmetric dimethylarginine and enhanced inflammation are associated with impaired vascular reactivity in women with endometriosis","volume":"219","author":"Kinugasa","year":"2011","journal-title":"Atherosclerosis"},{"key":"2026010712450092400_bib92","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/IGC.0b013e3181a19eca","article-title":"The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary","volume":"19","author":"Kobayashi","year":"2009","journal-title":"International Journal of Gynecological Cancer"},{"key":"2026010712450092400_bib93","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00404-011-1957-z","article-title":"Clinicopathological characteristics of ovarian carcinomas associated with endometriosis","volume":"285","author":"Kondi-Pafiti","year":"2012","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"2026010712450092400_bib94","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/146383","article-title":"The complementary and alternative medicine for endometriosis: a review of utilization and mechanism","volume":"2014","author":"Kong","year":"2014","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"2026010712450092400_bib95","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1210\/en.2010-1010","article-title":"Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model","volume":"152","author":"Kulak","year":"2011","journal-title":"Endocrinology"},{"key":"2026010712450092400_bib96","doi-asserted-by":"crossref","first-page":"63.e1","DOI":"10.1016\/j.ajog.2010.08.017","article-title":"Prognostic analysis of ovarian cancer associated with endometriosis","volume":"204","author":"Kumar","year":"2011","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib97","doi-asserted-by":"crossref","first-page":"e89742","DOI":"10.1371\/journal.pone.0089742","article-title":"Lipoxin A(4) prevents the progression of de novo and established endometriosis in a mouse model by attenuating prostaglandin E(2) production and estrogen signaling","volume":"9","author":"Kumar","year":"2014","journal-title":"PLoS ONE"},{"key":"2026010712450092400_bib98","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jcma.2013.07.008","article-title":"Ovarian cancers arising from endometriosis: a microenvironmental biomarker study including ER, HNF1ss, p53, PTEN, BAF250a, and COX-2","volume":"76","author":"Lai","year":"2013","journal-title":"Journal of the Chinese Medical Association"},{"key":"2026010712450092400_bib99","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1210\/en.2013-1168","article-title":"PPARgamma activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling","volume":"154","author":"Lebovic","year":"2013","journal-title":"Endocrinology"},{"key":"2026010712450092400_bib100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jri.2013.12.121","article-title":"Role of the CXCL12-CXCR4 axis in the development of deep rectal endometriosis","volume":"103","author":"Leconte","year":"2014","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib101","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1447-0756.2011.01734.x","article-title":"Effects of 17beta-estradiol on the release of monocyte chemotactic protein-1 and MAPK activity in monocytes stimulated with peritoneal fluid from endometriosis patients","volume":"38","author":"Lee","year":"2012","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712450092400_bib102","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fertnstert.2015.09.023","article-title":"Evidence of a genetic link between endometriosis and ovarian cancer","volume":"105","author":"Lee","year":"2016","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib103","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1517\/14656566.2014.916279","article-title":"Triptorelin for the treatment of endometriosis","volume":"15","author":"Leone Roberti Maggiore","year":"2014","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"2026010712450092400_bib104","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1447-0756.2009.01123.x","article-title":"Expression of macrophage migration inhibitory factor in human endometriosis: relation to disease stage, menstrual cycle and infertility","volume":"36","author":"Lin","year":"2010","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712450092400_bib105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/IGC.0b013e318231f140","article-title":"Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers","volume":"22","author":"Lowery","year":"2012","journal-title":"International Journal of Gynecological Cancer"},{"key":"2026010712450092400_bib106","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00404-013-3048-9","article-title":"Effect of lesion location on endometriotic adhesion and angiogenesis in SCID mice.","volume":"289","author":"Lu","year":"2014","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"2026010712450092400_bib107","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.fertnstert.2013.10.039","article-title":"Effect of oxygen tensions on the proliferation and angiogenesis of endometriosis heterograft in severe combined immunodeficiency mice.","volume":"101","author":"Lu","year":"2014","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib108","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/1933719109352380","article-title":"Regulation of monocyte chemotactic protein-1 expression in human endometrial endothelial cells by sex steroids: a potential mechanism for leukocyte recruitment in endometriosis","volume":"17","author":"Luk","year":"2010","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib109","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/humrep\/16.4.627","article-title":"Development of endometriosis-like lesions after transplantation of human endometrial fragments onto the chick embryo chorioallantoic membrane","volume":"16","author":"Maas","year":"2001","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-9966-29-4","article-title":"Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases","volume":"29","author":"Machado","year":"2010","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"2026010712450092400_bib111","first-page":"903","article-title":"A GFP endometriosis model reveals important morphological characteristics of the angiogenic process that govern benign and malignant diseases.","volume":"29","author":"Machado","year":"2014","journal-title":"Histology and Histopathology"},{"key":"2026010712450092400_bib112","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/09513590.2011.593664","article-title":"Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis","volume":"28","author":"Malhotra","year":"2012","journal-title":"Gynecological Endocrinology"},{"key":"2026010712450092400_bib113","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejogrb.2013.02.010","article-title":"Peritoneal fluid concentrations of beta-chemokines in endometriosis","volume":"169","author":"Margari","year":"2013","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive biology"},{"key":"2026010712450092400_bib114","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1309\/AJCPZ5T2POOFMQVN","article-title":"Distinct beta-catenin and PIK3CA mutation profiles in endometriosis-associated ovarian endometrioid and clear cell carcinomas","volume":"144","author":"Matsumoto","year":"2015","journal-title":"American Journal of Clinical Pathology"},{"key":"2026010712450092400_bib115","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/modpathol.2013.107","article-title":"Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles","volume":"27","author":"McConechy","year":"2014","journal-title":"Modern Pathology"},{"key":"2026010712450092400_bib116","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1471-0528.2010.02777.x","article-title":"Quantitative and qualitative peritoneal immune profiles, T-cell apoptosis and oxidative stress-associated characteristics in women with minimal and mild endometriosis","volume":"118","author":"Mier-Cabrera","year":"2011","journal-title":"British Journal of Obstetrics & Gynaecology"},{"key":"2026010712450092400_bib117","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jri.2011.05.008","article-title":"Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8","volume":"91","author":"Milewski","year":"2011","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib118","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1210\/me.2013-1421","article-title":"ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis","volume":"28","author":"Monsivais","year":"2014","journal-title":"Molecular Endocrinology"},{"key":"2026010712450092400_bib119","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ygyno.2011.10.001","article-title":"The association between endometriosis and ovarian cancer: a review of histological, genetic and molecular alterations","volume":"124","author":"Munksgaard","year":"2012","journal-title":"Gynecologic Oncology"},{"key":"2026010712450092400_bib120","first-page":"595","article-title":"Endometriosis: alternative methods of medical treatment","volume":"7","author":"Munoz-Hernando","year":"2015","journal-title":"International Journal of Womens Health"},{"key":"2026010712450092400_bib121","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ajog.2015.08.074","article-title":"Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis","volume":"214","author":"Muzii","year":"2016","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib122","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1093\/humrep\/deh408","article-title":"Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model","volume":"19","author":"Nap","year":"2004","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib123","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.fertnstert.2004.06.080","article-title":"Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane","volume":"83","author":"Nap","year":"2005","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib124","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1095\/biolreprod.113.114165","article-title":"Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model","volume":"90","author":"Naqvi","year":"2014","journal-title":"Biology of Reproduction"},{"key":"2026010712450092400_bib125","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1067\/mob.2003.408","article-title":"Endometriosis and ovarian cancer: thoughts on shared pathophysiology","volume":"189","author":"Ness","year":"2003","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib126","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.fertnstert.2008.08.007","article-title":"The relationship of endometriosis and ovarian malignancy: a review","volume":"90","author":"Nezhat","year":"2008","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib127","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.fertnstert.2012.07.1103","article-title":"Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers","volume":"98","author":"Novella-Maestre","year":"2012","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib128","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2026010712450092400_bib129","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1933719115600553","article-title":"Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models","volume":"23","author":"Palmer","year":"2016","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib130","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1470-2045(11)70404-1","article-title":"Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies","volume":"13","author":"Pearce","year":"2012","journal-title":"Lancet Oncology"},{"key":"2026010712450092400_bib131","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.fertnstert.2012.06.056","article-title":"The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis","volume":"98","author":"Pellegrini","year":"2012","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib132","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0897.2012.01173.x","article-title":"CD4(+) CD25(high) Foxp3(+) cells increased in the peritoneal fluid of patients with endometriosis","volume":"68","author":"Podgaec","year":"2012","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib133","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10103-014-1630-4","article-title":"Treatment efficacy for pain complaints in women with endometriosis of the lesser pelvis after laparoscopic electroablation vs. CO2 laser ablation","volume":"30","author":"Posadzka","year":"2015","journal-title":"Lasers in Medical Science"},{"key":"2026010712450092400_bib134","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fertnstert.2014.02.012","article-title":"Treatment of pelvic pain associated with endometriosis: a committee opinion","volume":"101","author":"Practice Committee of the American Society for Reproductive M","year":"2014","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib135","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3109\/09513590.2014.920318","article-title":"Distinct peritoneal fluid ghrelin and leptin in infertile women with endometriosis and their correlation with interleukin-6 and vascular endothelial growth factor","volume":"30","author":"Rathore","year":"2014","journal-title":"Gynecological Endocrinology"},{"key":"2026010712450092400_bib136","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/1933719110395406","article-title":"Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis","volume":"18","author":"Ricci","year":"2011","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib137","first-page":"1357","article-title":"Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery","volume":"19","author":"Rossing","year":"2008","journal-title":"Cancer Causes Control"},{"key":"2026010712450092400_bib138","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejogrb.2010.06.023","article-title":"Is acupuncture in addition to conventional medicine effective as pain treatment for endometriosis? A randomised controlled cross-over trial","volume":"153","author":"Rubi-Klein","year":"2010","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"2026010712450092400_bib139","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1177\/1933719110379920","article-title":"Basal and steroid hormone-regulated expression of CXCR4 in human endometrium and endometriosis","volume":"17","author":"Ruiz","year":"2010","journal-title":"Reproductive Sciences"},{"key":"2026010712450092400_bib140","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/08820139.2014.909453","article-title":"IL-17A concentration of seminal plasma and follicular fluid in infertile men and women with various clinical diagnoses","volume":"43","author":"Sabbaghi","year":"2014","journal-title":"Immunological Investigations"},{"key":"2026010712450092400_bib141","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/modpathol.2011.217","article-title":"Loss of ARID1A\/BAF250a-expression in endometriosis: a biomarker for risk of carcinogenic transformation?","volume":"25","author":"Samartzis","year":"2012","journal-title":"Modern Pathology"},{"key":"2026010712450092400_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archsurg.1925.01120100007001","article-title":"Endometrial carcinoma of the ovary, arising in endometrial tissue in that organ","volume":"10","author":"Sampson","year":"1925","journal-title":"Archives of Surgery"},{"key":"2026010712450092400_bib143","first-page":"93","article-title":"Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation.","volume":"3","author":"Sampson","year":"1927","journal-title":"American Journal of Pathology"},{"key":"2026010712450092400_bib144","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9378(15)30003-X","article-title":"Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity.","volume":"14","author":"Sampson","year":"1927","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.fertnstert.2012.08.055","article-title":"Interleukin-19 and interleukin-22 serum levels are decreased in patients with ovarian endometrioma","volume":"99","author":"Santulli","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib146","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ygyno.2014.03.017","article-title":"Characteristics of clear cell ovarian cancer arising from endometriosis: a two center cohort study","volume":"133","author":"Scarfone","year":"2014","journal-title":"Gynecologic Oncology"},{"key":"2026010712450092400_bib147","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ygyno.2010.06.003","article-title":"SGO White Paper on ovarian cancer: etiology, screening and surveillance","volume":"119","author":"Schorge","year":"2010","journal-title":"Gynecologic Oncology"},{"key":"2026010712450092400_bib148","first-page":"283","article-title":"Malignant changes in endometriosis","volume":"2","author":"Scott","year":"1953","journal-title":"Obstetrics and Gynecology"},{"key":"2026010712450092400_bib149","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0002-9378(16)38618-5","article-title":"Further studies on experimental endometriosis","volume":"66","author":"Scott","year":"1953","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0897.2012.01147.x","article-title":"Imbalance in cytokines from interleukin-1 family \u2013 role in pathogenesis of endometriosis","volume":"68","author":"Sikora","year":"2012","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib151","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0015-0282(16)58521-5","article-title":"Ectopic growth of endometrium depends on its structural integrity and proteolytic activity in the cynomolgus monkey (Macaca fascicularis) model of endometriosis","volume":"66","author":"Sillem","year":"1996","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib152","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1093\/humrep\/14.12.2944","article-title":"Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis","volume":"14","author":"Somigliana","year":"1999","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib153","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2147\/IJWH.S77202","article-title":"Safety and tolerability of dienogest in endometriosis: pooled analysis from the European clinical study program","volume":"7","author":"Strowitzki","year":"2015","journal-title":"International Journal of Womens Health"},{"key":"2026010712450092400_bib154","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/en.2007-1225","article-title":"Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model","volume":"149","author":"Styer","year":"2008","journal-title":"Endocrinology"},{"key":"2026010712450092400_bib155","doi-asserted-by":"crossref","first-page":"E1191","DOI":"10.1210\/jc.2013-2525","article-title":"Peroxisome proliferator-activated receptor gamma, coactivator 1alpha enhances local estrogen biosynthesis by stimulating aromatase activity in endometriosis.","volume":"99","author":"Suganuma","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712450092400_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(16)59280-2","article-title":"Peritoneal fluid environment and infertility","volume":"48","author":"Syrop","year":"1987","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib157","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1071\/RD12258","article-title":"Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment","volume":"26","author":"Szubert","year":"2014","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712450092400_bib158","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/AOG.0b013e31824264c3","article-title":"Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial","volume":"119","author":"Tanmahasamut","year":"2012","journal-title":"Obstetrics and Gynecology"},{"key":"2026010712450092400_bib159","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-0897.2010.00920.x","article-title":"The peritoneal leptin, MCP-1 and TNF-alpha in the pathogenesis of endometriosis-associated infertility","volume":"65","author":"Tao","year":"2011","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib160","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0002-9378(50)90517-5","article-title":"Experimental endometriosis","volume":"60","author":"Te Linde","year":"1950","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib161","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jri.2010.05.001","article-title":"Endometriosis research: animal models for the study of a complex disease","volume":"86","author":"Tirado-Gonzalez","year":"2010","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib162","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.ajpath.2012.05.018","article-title":"Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis","volume":"181","author":"Veillat","year":"2012","journal-title":"American Journal of Pathology"},{"key":"2026010712450092400_bib163","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jri.2009.11.004","article-title":"Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression","volume":"84","author":"Velasco","year":"2010","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib164","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0015-0282(16)48988-0","article-title":"Studies on the surgical induction of endometriosis in the rat","volume":"44","author":"Vernon","year":"1985","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib165","first-page":"386","article-title":"Blocking of stromal cell-derived factor-1 reduces neoangiogenesis in human endometriosis lesions in a mouse model","volume":"70","author":"Virani","year":"2013","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010712450092400_bib166","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1677\/JME-09-0177","article-title":"The high level of RANTES in the ectopic milieu recruits macrophages and induces their tolerance in progression of endometriosis","volume":"45","author":"Wang","year":"2010","journal-title":"Journal of Molecular Endocrinology"},{"key":"2026010712450092400_bib167","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/PGP.0b013e31821f4b85","article-title":"Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects","volume":"30","author":"Wei","year":"2011","journal-title":"International Journal of Gynecological Pathology"},{"key":"2026010712450092400_bib168","first-page":"11307","article-title":"Chinese medicinal plants for advanced endometriosis after conservative surgery: a prospective, multi-center and controlled trial","volume":"8","author":"Weng","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"2026010712450092400_bib169","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00404-013-2828-6","article-title":"Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis","volume":"288","author":"Wickiewicz","year":"2013","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"2026010712450092400_bib170","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1008433","article-title":"ARID1A mutations in endometriosis-associated ovarian carcinomas","volume":"363","author":"Wiegand","year":"2010","journal-title":"New England Journal of Medicine"},{"key":"2026010712450092400_bib171","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/path.2911","article-title":"Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas","volume":"224","author":"Wiegand","year":"2011","journal-title":"Journal of Pathology"},{"key":"2026010712450092400_bib172","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.ejca.2015.05.011","article-title":"Molecular changes in endometriosis-associated ovarian clear cell carcinoma","volume":"51","author":"Worley","year":"2015","journal-title":"European Journal of Cancer"},{"key":"2026010712450092400_bib173","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tjog.2012.01.010","article-title":"Estrogen receptor expression affected by hypoxia inducible factor-1alpha in stromal cells from patients with endometriosis","volume":"51","author":"Wu","year":"2012","journal-title":"Taiwanese Journal of Obstetrics & Gynecology"},{"key":"2026010712450092400_bib174","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.fertnstert.2011.07.008","article-title":"Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C\/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo","volume":"96","author":"Xu","year":"2011","journal-title":"Fertility and Sterility"},{"key":"2026010712450092400_bib175","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10456-013-9333-1","article-title":"Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis","volume":"16","author":"Xu","year":"2013","journal-title":"Angiogenesis"},{"key":"2026010712450092400_bib176","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.acthis.2012.10.006","article-title":"Elevated immunoreactivity of RANTES and CCR1 correlate with the severity of stages and dysmenorrhea in women with deep infiltrating endometriosis","volume":"115","author":"Yang","year":"2013","journal-title":"Acta Histochemica"},{"key":"2026010712450092400_bib177","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.7150\/ijms.5169","article-title":"Increased expression of pattern recognition receptors and nitric oxide synthase in patients with endometriosis","volume":"10","author":"Yeo","year":"2013","journal-title":"International Journal of Medical Sciences"},{"key":"2026010712450092400_bib178","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1210\/jc.2014-1026","article-title":"Transforming growth factor-beta induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis.","volume":"99","author":"Young","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712450092400_bib179","doi-asserted-by":"crossref","first-page":"e106773","DOI":"10.1371\/journal.pone.0106773","article-title":"The peritoneum is both a source and target of TGF-beta in women with endometriosis.","author":"Young","year":"2014","journal-title":"PLoS ONE"},{"key":"2026010712450092400_bib180","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0002-9378(84)90240-0","article-title":"Transplantation of normal and ectopic human endometrial tissue into athymic nude mice","volume":"149","author":"Zamah","year":"1984","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712450092400_bib181","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/gyno.2000.5905","article-title":"Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis","volume":"79","author":"Zanetta","year":"2000","journal-title":"Gynecologic Oncology"},{"key":"2026010712450092400_bib182","doi-asserted-by":"crossref","first-page":"271ra279","DOI":"10.1126\/scitranslmed.3010626","article-title":"Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis","volume":"7","author":"Zhao","year":"2015","journal-title":"Science Translational Medicine"},{"key":"2026010712450092400_bib183","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/191967","article-title":"Medical treatments for endometriosis-associated pelvic pain","volume":"2014","author":"Zito","year":"2014","journal-title":"BioMed Research International"},{"key":"2026010712450092400_bib184","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/humrep\/deh052","article-title":"Familial aggregation of endometriosis in a large pedigree of rhesus macaques","volume":"19","author":"Zondervan","year":"2004","journal-title":"Human Reproduction"},{"key":"2026010712450092400_bib185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00404-015-3641-1","article-title":"Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review","volume":"292","author":"Zorbas","year":"2015","journal-title":"Archives of Gynecology and Obstetrics"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/152\/3\/R63.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/152\/3\/R63\/64133981\/r63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/152\/3\/R63\/64133981\/r63.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:46:08Z","timestamp":1767807968000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/152\/3\/R63\/8236210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":185,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-16-0052","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9,1]]},"published":{"date-parts":[[2016,9,1]]}}}