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Daughters born to PCOS mothers constitute a high-risk group for metabolic and reproductive derangements, but no report has described potential growth and metabolic risk factors for such female offspring. Hence, we used a mouse model of dehydroepiandrosterone (DHEA)-induced PCOS to study the mechanisms underlying the pathology of PCOS by investigating the growth, developmental characteristics, metabolic indexes and expression profiles of key genes of offspring born to the models. We found that the average litter size was significantly smaller in the DHEA group, and female offspring had sustained higher body weight, increased body fat and triglyceride content in serum and liver; they also exhibited decreased energy expenditure, oxygen consumption and impaired glucose tolerance. Genes related to glucolipid metabolism such as Ppar\u03b3, Acot1\/2, Fgf21, Pdk4 and Inhbb were upregulated in the liver of the offspring in DHEA group compared with those in controls, whereas Cyp17a1 expression was significantly decreased. However, the expression of these genes was not detected in male offspring. Our results show that female offspring in DHEA group exhibit perturbed growth and glucolipid metabolism that were not observed in male offspring.<\/jats:p>","DOI":"10.1530\/rep-16-0081","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T23:50:03Z","timestamp":1477093803000},"page":"705-714","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults"],"prefix":"10.1093","volume":"152","author":[{"given":"Ying","family":"Huang","sequence":"first","affiliation":[{"name":"Reproductive Medical Center Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"Key Laboratory of Assisted Reproduction Ministry of Education, Beijing, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Man","family":"Gao","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"Key Laboratory of Assisted Reproduction Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Cui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Department of Obstetrics and Gynecology, Peking University Third Hospital, 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