{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:24:47Z","timestamp":1767810287176,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Reciprocal epithelial\u2013mesenchymal interactions and several signalling pathways regulate the development of the genital tubercle (GT), an embryonic primordium of external genitalia. The morphology of the adult male external genitalia of the Asian house musk shrew Suncus murinus (hereafter, laboratory name: suncus) belonging to the order Eulipotyphla (the former order Insectivora or Soricomorpha) differs from those of mice and humans. However, the developmental process of the suncus GT and its regulatory genes are unknown. In the present study, we explored the morphological changes and gene expression patterns during the development of the suncus GT. Morphological observations suggested the presence of common (during the initial outgrowth) and species-specific (during the sexual differentiation of GT) developmental processes of the suncus GT. In gene expression analysis, fibroblast growth factor 8 (Fgf8) and sonic hedgehog (Shh), an indicator and regulator of GT development in mice respectively, were found to be expressed in the cloacal epithelium and the developing urethral epithelium of the suncus GT. This pattern of expression specifically in GT epithelium is similar to that observed in the developing mouse GT. Our results indicate that the mechanism of GT formation regulated by the FGF and SHH signalling pathways is widely conserved in mammals.<\/jats:p>","DOI":"10.1530\/rep-16-0231","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T21:35:41Z","timestamp":1479159341000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["Expression patterns of\n                    <i>Fgf8<\/i>\n                    and\n                    <i>Shh<\/i>\n                    in the developing external genitalia of\n                    <i>Suncus murinus<\/i>"],"prefix":"10.1093","volume":"153","author":[{"given":"Mami","family":"Miyado","sequence":"first","affiliation":[{"name":"Department of Molecular Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Miyado","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology \u00a0 National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology \u00a0 National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Fukami","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics \u00a0 Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen-ichi","family":"Oda","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Management and Resources \u00a0 Department of 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