{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:28:50Z","timestamp":1767810530441,"version":"3.49.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to selenium-binding protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n\u2009=\u200941), infertility (n\u2009=\u200992) and control (n\u2009=\u200987) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis. The percent of anti-SBP1-positive sera was higher in POF (P\u2009=\u20090.02), irregular ovulation (P\u2009=\u20090.001), unexplained causes (P\u2009=\u20090.02), late (III\u2013IV)-stage OvCa (P\u2009=\u20090.02) but was not significant in endometriosis, benign ovarian tumors\/cysts, early stage (I\u2013II) OvCa or uterine cancer compared to healthy controls. Anti-SBP1 was significantly higher in women with serous (P\u2009=\u20090.04) but not non-serous (P\u2009=\u20090.33) OvCa compared to controls. Also, we determined if anti-SBP1 was associated with CA125 or anti-TP53, markers often studied in OvCa. Anti-TP53 and CA125 were measured by established immunoassays. The ability of anti-SBP1 alone to discriminate infertility or OvCa from controls or when combined with anti-TP53 and CA125, to identify OvCa was evaluated by comparing the area under the curve (AUC) in ROC analysis. Anti-SBP1 alone discriminated infertility (AUC\u2009=\u20090.7; P\u2009=\u20090.001) or OvCa (AUC\u2009=\u20090.67; P\u2009=\u20090.03) from controls. The sensitivity and specificity of OvCa identification was increased by combining CA125, anti-TP53 and anti-SBP1 (AUC\u2009=\u20090.96). Therefore, anti-SBP1 occurs in infertile women with POF, ovulatory disturbances or unexplained infertility and in serous OvCa. This suggests an autoimmune process is associated with the development of serous OvCa.<\/jats:p>","DOI":"10.1530\/rep-16-0265","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T21:00:34Z","timestamp":1481662834000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["Selenium-Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer"],"prefix":"10.1093","volume":"153","author":[{"given":"Yi","family":"Yu-Rice","sequence":"first","affiliation":[{"name":"Department of Pharmacology \u00a0 Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seby L","family":"Edassery","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Urban","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center \u00a0 Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingegerd","family":"Hellstrom","sequence":"additional","affiliation":[{"name":"Department of Pathology \u00a0 Harborview Medical Center, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Erik","family":"Hellstrom","sequence":"additional","affiliation":[{"name":"Department of Pathology \u00a0 Harborview Medical Center, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics \u00a0 Rush University Medical Center, Chicago, Illinois, 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