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Holstein cows were assigned randomly to either a control (n\u2009=\u2009373) or the same diet supplemented daily with 100\u2009g\/cow of an algae product containing 10% DHA (algae, n\u2009=\u2009366) from 27 to 147 days postpartum. Measurements included yields of milk and milk components, fatty acids (FA) profiles in milk fat and plasma phospholipids, resumption of ovulation by 57 days postpartum, pregnancy per artificial insemination (AI) and expression of interferon-stimulated genes in leukocytes. Feeding algae increased resumption of estrous cyclicity (77.6 vs 65.9%) and pregnancy at first AI (47.6 vs 32.8%) in primiparous cows. Algae increased pregnancy per AI in all AI in both primiparous and multiparous cows (41.6 vs 30.7%), which reduced days to pregnancy by 22 days (102 vs 124 days) compared with control cows. Pregnant cows fed algae had greater expression of RTP4 in blood leukocytes compared with those in pregnant control cows. Feeding algae increased the incorporation of DHA, eicosapentaenoic acid, conjugated linoleic acid isomers cis-9 trans-11, trans-10 cis-12 and total n-3 FA in phospholipids in plasma and milk fat. Yields of milk and true protein increased by 1.1\u2009kg\/day and 30\u2009g\/day respectively, whereas fat yield decreased 40\u2009g\/day in algae compared with that in control. Supplementing DHA-rich algae altered the FA composition of lipid fractions and improved reproduction in dairy cows. The benefits on reproduction might be mediated by enhanced embryo development based on changes in interferon-stimulated gene expression.<\/jats:p>","DOI":"10.1530\/rep-16-0642","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T20:30:29Z","timestamp":1487968229000},"page":"707-723","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":69,"title":["Effects of supplementation with docosahexaenoic acid on reproduction of dairy cows"],"prefix":"10.1093","volume":"153","author":[{"given":"Let\u00edcia D P","family":"Sinedino","sequence":"first","affiliation":[{"name":"Department of Animal Sciences \u00a0 University of Florida, Gainesville, Florida, USA"},{"name":"DH Barron Reproductive and Perinatal Biology Research Program \u00a0 University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia R L","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L","family":"Lock","sequence":"additional","affiliation":[{"name":"Department of Animal Science \u00a0 Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice P","family":"Boland","sequence":"additional","affiliation":[{"name":"Alltech Inc. \u00a0 Nicholasville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R","family":"Staples","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W","family":"Thatcher","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 University of Florida, Gainesville, Florida, USA"},{"name":"DH Barron Reproductive and Perinatal Biology Research Program \u00a0 University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E P","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences \u00a0 University of Florida, Gainesville, Florida, USA"},{"name":"DH Barron Reproductive and Perinatal Biology Research Program \u00a0 University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"2026010712124871100_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1054\/plef.1999.0101","article-title":"Effects of altering dietary fatty acid composition on prostaglandin synthesis and fertility","volume":"61","author":"Abayasekara","year":"1999","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"2026010712124871100_bib2","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0022-2275(20)41345-8","article-title":"Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column","volume":"33","author":"Agren","year":"1992","journal-title":"Journal of Lipid Research"},{"key":"2026010712124871100_bib3","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.3168\/jds.S0022-0302(06)72581-4","article-title":"Lower pregnancy losses in lactating dairy cows fed a diet enriched in \u03b1-linolenic acid","volume":"89","author":"Ambrose","year":"2006","journal-title":"Journal of Dairy Science"},{"key":"2026010712124871100_bib4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev.nutr.012809.104648","article-title":"Nutrigenomics, rumen-derived bioactive fatty acids, and the regulation of milk fat synthesis","volume":"31","author":"Bauman","year":"2011","journal-title":"Annual Review of Nutrition"},{"key":"2026010712124871100_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jnutbio.2015.02.001","article-title":"Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids","volume":"26","author":"Bhaswanta","year":"2015","journal-title":"Journal of Nutritional Biochemistry"},{"key":"2026010712124871100_bib6","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.3168\/jds.S0022-0302(06)72374-8","article-title":"Pregnancy, bovine somatotropin, and dietary n-3 fatty acids in lactating dairy cows: II. 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