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Testis regression leads to reductions in daily sperm production and in the quality of ejaculated spermatozoa (poorer movement, DNA damage). There is also a reduction in spermatogenic efficiency that appears to be caused, at least partially, by increases in germ cell apoptosis. Sertoli cell number does not change with testis regression, although about 1% of Sertoli cells do appear to retain proliferative ability after puberty. On the other hand, Sertoli cell function is disrupted during testis regression, as evidenced by a disorganization of tight junctions and indications that cell differentiation and maturation are reversed. Disrupted Sertoli cell function can explain, at least partially, the increase in germ cell apoptosis and any decrease in the rate of spermatogenesis, the two major contributors to spermatogenic efficiency. These outcomes seem to be mediated by changes in two RNA-based processes: (i) the expression of small non-coding RNAs that are involved in the regulation of Sertoli cell function, spermatogenesis and germ cell apoptosis and (ii) alternative pre-mRNA splicing that affects the regulation of spermatogenesis but does not appear to affect germ cell apoptosis, at least during testis progression induced by undernutrition in the male sheep. These research outcomes can be extended to other animal models and are relevant to issues in human male fertility.<\/jats:p>","DOI":"10.1530\/rep-17-0061","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T20:20:12Z","timestamp":1507234812000},"page":"R133-R141","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["Cellular and molecular responses of adult testis to changes in nutrition: novel insights from the sheep model"],"prefix":"10.1093","volume":"154","author":[{"given":"Yongjuan","family":"Guan","sequence":"first","affiliation":[{"name":"UWA Institute of Agriculture and School of Agriculture and Environment M087 , University of Western Australia, Crawley, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme B","family":"Martin","sequence":"additional","affiliation":[{"name":"UWA Institute of Agriculture and School of Agriculture and Environment 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