{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:26:54Z","timestamp":1791959214454,"version":"4.3.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recently, the influence of adrenergic activity over ovarian function, and thus fertility, has begun to gain importance. Previous studies have shown that adrenergic activity through norepinephrine (NE) participates in the control of follicular development and steroidal secretion from the ovary, among other functions. To examine this phenomenon, the denervation of the gonad has been widely used to observe changes in the ovary\u2019s performance. Nevertheless, the effect of the absence of adrenergic nerves in the ovary has only been studied in short times periods. In the present work, we used guanethidine (a drug that produces an irreversible sympathectomy) during the infantile period of rats, and we observed its effects in the adult rat (6 months old). Our results indicate that ovarian NE content is recovered at 6 months old, alongside with an increase of the adrenal content of NE and a dysfunctional celiac ganglion. Together, these results suggest that the recovery of ovarian NE does not come from a neural origin. In addition, ovarian performance was impaired because the changes in follicular development and steroidal secretion are not recovered despite the recovery of ovarian NE content. In conclusion, these results suggest that the nerve\u2013ovarian connections, which are established during infantile development, are necessary for the accurate response of the ovary to sympathetic stimulation.<\/jats:p>","DOI":"10.1530\/rep-17-0318","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T20:40:25Z","timestamp":1511296825000},"page":"171-179","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":11,"title":["Effects of sympathectomy on ovarian follicular development and steroid secretion"],"prefix":"10.1093","volume":"155","author":[{"given":"Maritza P","family":"Garrido","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology , Laboratory for Neurobiochemistry Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile"},{"name":"Department of Obstetrics and Gynecology , Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital University of Chile, Clinical Hospital, Faculty of Medicine, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fernandois","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology , Laboratory for Neurobiochemistry Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Venegas","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Gastroenterolog\u00eda , Hospital Cl\u00ednico Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso H","family":"Paredes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology , Laboratory for Neurobiochemistry Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"2026010712165795700_bib1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1477-7827-7-64","article-title":"Increases in norepinephrine release and ovarian cyst formation during ageing in the rat.","volume":"7","author":"Acuna","year":"2009","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010712165795700_bib2","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1016\/S0021-9258(20)65107-9","article-title":"Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells","volume":"257","author":"Adashi","year":"1982","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712165795700_bib3","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1210\/endo-114-5-1944","article-title":"Ovarian adrenergic nerves play a role in maintaining preovulatory steroid secretion.","volume":"114","author":"Aguado","year":"1984","journal-title":"Endocrinology"},{"key":"2026010712165795700_bib4","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1210\/endo-114-5-1845","article-title":"Prepubertal ovarian function is finely regulated by direct adrenergic influences. 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