{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:42:36Z","timestamp":1784637756501,"version":"3.55.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The pioneering of intracytoplasmic sperm injection (ICSI) approximately 25 years ago revolutionized the treatment of infertile couples. Today, ICSI remains an indispensable part of assisted reproductive treatments (ART) and has resulted in the birth of millions of babies. The 25th anniversary of ICSI marks a chronologic landmark in its evolving history. This landmark also serves as an opportunity to thoroughly appraise the safety of ICSI and analyze the long-term outcomes of ICSI-conceived children. In this review, we collate and analyze salient data accrued over the past 25 years pertaining to the long-term safety of ICSI and ICSI conceptions. We also evaluate the effects of ICSI on the perinatal outcomes, congenital malformation rates, cognitive development and reproductive health of ICSI-conceived neonates, children, adolescents and adults, respectively. In doing so, we also highlight the existence of potential confounders and biases that frequently obscure the interpretation of clinical follow-up studies.<\/jats:p>","DOI":"10.1530\/rep-17-0344","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T20:40:25Z","timestamp":1500064825000},"page":"F61-F70","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":32,"title":["The safety of intracytoplasmic sperm injection and long-term outcomes"],"prefix":"10.1093","volume":"154","author":[{"given":"Nigel","family":"Pereira","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine , Weill Cornell Medicine, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine , Weill Cornell Medicine, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Lu","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine , Weill Cornell Medicine, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev","family":"Rosenwaks","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine , Weill Cornell Medicine, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero D","family":"Palermo","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine , Weill Cornell Medicine, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"2026010712150460300_bib1","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1093\/humrep\/13.10.2958","article-title":"Obstetric outcome after prenatal diagnosis in pregnancies obtained after intracytoplasmic sperm injection.","volume":"13","author":"Aytoz","year":"1998","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/AOG.0000000000001837","article-title":"Neurodevelopmental outcomes after assisted reproductive technologies","volume":"129","author":"Balayla","year":"2017","journal-title":"Obstetrics and Gynecology"},{"key":"2026010712150460300_bib3","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/humrep\/deh239","article-title":"The influence of assisted reproduction on family functioning and children\u2019s socio-emotional development: results from a European study","volume":"19","author":"Barnes","year":"2004","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib4","doi-asserted-by":"crossref","first-page":"B:135","DOI":"10.1016\/j.placenta.2008.08.013","article-title":"Follow-up of children born after ART","volume":"29","author":"Basatemur","year":"2008","journal-title":"Placenta"},{"key":"2026010712150460300_bib5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.fertnstert.2013.05.034","article-title":"Assisted reproduction and child neurodevelopmental outcomes: a systematic review","volume":"100","author":"Bay","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib6","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/humrep\/deq249","article-title":"Serum inhibin B concentrations in pubertal boys conceived by ICSI: first results","volume":"25","author":"Belva","year":"2010","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/humrep\/deq345","article-title":"Salivary testosterone concentrations in pubertal ICSI boys compared with spontaneously conceived boys","volume":"26","author":"Belva","year":"2011","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/humrep\/der375","article-title":"Are ICSI adolescents at risk for increased adiposity?","volume":"27","author":"Belva","year":"2012","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib9","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/humrep\/des259","article-title":"Blood pressure in ICSI-conceived adolescents","volume":"27","author":"Belva","year":"2012","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib10","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/humrep\/des001","article-title":"Pubertal development in ICSI children","volume":"27","author":"Belva","year":"2012","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib11","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/humrep\/dew245","article-title":"Semen quality of young adult ICSI offspring: the first results","volume":"31","author":"Belva","year":"2016","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humrep\/dew324","article-title":"Reproductive hormones of ICSI-conceived young adult men: the first results","volume":"32","author":"Belva","year":"2017","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib13","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.fertnstert.2017.02.102","article-title":"Serum reproductive hormone levels and ultrasound findings in female offspring after intracytoplasmic sperm injection: first results","volume":"107","author":"Belva","year":"2017","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.1787609","article-title":"An operational definition of epigenetics","volume":"23","author":"Berger","year":"2009","journal-title":"Genes and Development"},{"key":"2026010712150460300_bib15","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1093\/oxfordjournals.humrep.a135914","article-title":"Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization","volume":"10","author":"Bonduelle","year":"1995","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib16","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/oxfordjournals.humrep.a019437","article-title":"Prospective follow-up study of 423 children born after intracytoplasmic sperm injection","volume":"11","author":"Bonduelle","year":"1996","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib17","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(98)24021-9","article-title":"Mental development of 201 ICSI children at 2 years of age.","volume":"351","author":"Bonduelle","year":"1998","journal-title":"Lancet"},{"key":"2026010712150460300_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/humrep\/13.suppl_1.196","article-title":"A follow-up study of children born after intracytoplasmic sperm injection (ICSI) with epididymal and testicular spermatozoa and after replacement of cryopreserved embryos obtained after ICSI","volume":"13","author":"Bonduelle","year":"1998","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humrep\/14.suppl_1.243","article-title":"Seven years of intracytoplasmic sperm injection and follow-up of 1987 subsequent children","volume":"14","author":"Bonduelle","year":"1999","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/humrep\/deg061","article-title":"Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF","volume":"18","author":"Bonduelle","year":"2003","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1472-6483(10)62116-5","article-title":"Collaborative Study Group of Brussels, Gothenburg and New York","volume":"9","author":"Bonduelle","year":"2004","journal-title":"Reproductive BioMedicine Online"},{"key":"2026010712150460300_bib22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jama.2014.17985","article-title":"Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection","volume":"313","author":"Boulet","year":"2015","journal-title":"JAMA"},{"key":"2026010712150460300_bib23","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1093\/humrep\/dem268","article-title":"A survey of assisted reproductive technology births and imprinting disorders","volume":"22","author":"Bowdin","year":"2007","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib24","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0140-6736(98)10168-X","article-title":"Medical and developmental outcome at 1 year for children conceived by intracytoplasmic sperm injection","volume":"351","author":"Bowen","year":"1998","journal-title":"Lancet"},{"key":"2026010712150460300_bib25","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1093\/humrep\/dew232","article-title":"Population trends and live birth rates associated with common ART treatment strategies","volume":"31","author":"Chambers","year":"2016","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10815-014-0245-9","article-title":"Neonatal outcome of early rescue ICSI and ICSI with ejaculated sperm","volume":"31","author":"Chen","year":"2014","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"2026010712150460300_bib27","first-page":"455","article-title":"Treatment of male infertility by in vitro fertilization: factors affecting fertilization and pregnancy","volume":"15","author":"Cohen","year":"1984","journal-title":"Acta Europaea Fertilitatis"},{"key":"2026010712150460300_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/oxfordjournals.humrep.a136923","article-title":"Partial zona dissection of human oocytes when failure of zona pellucida penetration is anticipated","volume":"4","author":"Cohen","year":"1989","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000223421","article-title":"Testicular growth and tubular function in prepubertal boys conceived by intracytoplasmic sperm injection","volume":"71","author":"De Schepper","year":"2009","journal-title":"Hormone Research"},{"key":"2026010712150460300_bib30","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/humrep\/dem172","article-title":"Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study","volume":"22","author":"Doornbos","year":"2007","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib31","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/humrep\/dew082","article-title":"International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology 2008, 2009 and 2010","volume":"31","author":"Dyer","year":"2016","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.rbmo.2013.01.014","article-title":"Maternal and neonatal health outcomes following assisted reproduction","volume":"26","author":"Farhi","year":"2013","journal-title":"Reproductive BioMedicine Online"},{"key":"2026010712150460300_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.rbmo.2013.10.013","article-title":"Health outcomes of children born after IVF\/ICSI: a review of current expert opinion and literature","volume":"28","author":"Fauser","year":"2014","journal-title":"Reproductive BioMedicine Online"},{"key":"2026010712150460300_bib34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/humrep\/des377","article-title":"Neonatal outcome and congenital malformations in children born after ICSI with testicular or epididymal sperm: a controlled national cohort study","volume":"28","author":"Fedder","year":"2013","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib35","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/jpepsy\/jsn120","article-title":"Cognitive development of singletons conceived by intracytoplasmic sperm injection or in vitro fertilization at age 5 and 10 years","volume":"34","author":"Goldbeck","year":"2009","journal-title":"Journal of Pediatric Psychology"},{"key":"2026010712150460300_bib36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJMoa010035","article-title":"The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization","volume":"346","author":"Hansen","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"2026010712150460300_bib37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12522-014-0183-3","article-title":"Imprinting methylation errors in ART","volume":"13","author":"Hiura","year":"2014","journal-title":"Reproductive Medicine and Biology"},{"key":"2026010712150460300_bib38","doi-asserted-by":"crossref","first-page":"1432.e1","DOI":"10.1016\/j.fertnstert.2015.02.026","article-title":"Neonatal outcomes after early rescue intracytoplasmic sperm injection: an analysis of a 5-year period","volume":"103","author":"Huang","year":"2015","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/humrep\/deu338","article-title":"Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children","volume":"30","author":"Kissin","year":"2015","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib40","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/humrep\/dem040","article-title":"Matched follow-up study of 5\u20138 year old ICSI-singletons: comparison of their neuromotor development to IVF and naturally conceived singletons","volume":"22","author":"Knoester","year":"2007","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib41","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.fertnstert.2007.04.049","article-title":"Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons","volume":"89","author":"Knoester","year":"2008","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fertnstert.2007.06.090","article-title":"Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception","volume":"90","author":"Knoester","year":"2008","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib43","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/humupd\/dmu033","article-title":"A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF\/ICSI compared with children conceived spontaneously","volume":"20","author":"Lazaraviciute","year":"2014","journal-title":"Human Reproduction Update"},{"key":"2026010712150460300_bib44","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/humrep\/deg408","article-title":"Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age","volume":"18","author":"Leslie","year":"2003","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib45","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1093\/humrep\/del266","article-title":"Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children","volume":"21","author":"Leunens","year":"2006","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/humrep\/dem257","article-title":"Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children","volume":"23","author":"Leunens","year":"2008","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib47","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/ije\/dyh363","article-title":"Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis","volume":"34","author":"Lie","year":"2005","journal-title":"International Journal of Epidemiology"},{"key":"2026010712150460300_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1472-6483(10)61621-5","article-title":"Malformation rate in fetuses and children conceived after ICSI: results of a prospective cohort study","volume":"5","author":"Ludwig","year":"2002","journal-title":"Reproductive BioMedicine Online"},{"key":"2026010712150460300_bib49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0015-0282(16)58397-6","article-title":"Reinsemination of one-day-old oocytes by use of intracytoplasmic sperm injection","volume":"66","author":"Lundin","year":"1996","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib50","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1093\/humrep\/deg486","article-title":"Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs?","volume":"18","author":"Maher","year":"2003","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib51","doi-asserted-by":"crossref","first-page":"1673.e5","DOI":"10.1016\/j.fertnstert.2016.09.011","article-title":"Behavioral, cognitive, and motor performance and physical development of five-year-old children who were born after intracytoplasmic sperm injection with the use of testicular sperm","volume":"106","author":"Meijerink","year":"2016","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/humupd\/dmn005","article-title":"Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI-a systematic review","volume":"14","author":"Middelburg","year":"2008","journal-title":"Human Reproduction Update"},{"key":"2026010712150460300_bib53","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/01.grf.0000197503.45076.56","article-title":"Genetic assessment and development of children that result from assisted reproductive technology","volume":"49","author":"Neri","year":"2006","journal-title":"Clinical Obstetrics and Gynecology"},{"key":"2026010712150460300_bib54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo","year":"1992","journal-title":"Lancet"},{"key":"2026010712150460300_bib55","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0015-0282(16)57603-1","article-title":"Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility","volume":"63","author":"Palermo","year":"1995","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib56","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1001\/jama.1996.03540230043033","article-title":"Evolution of pregnancies and initial follow-up of newborns delivered after intracytoplasmic sperm injection","volume":"276","author":"Palermo","year":"1996","journal-title":"JAMA"},{"key":"2026010712150460300_bib57","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S1472-6483(10)60411-7","article-title":"Genetic and epigenetic characteristics of ICSI children","volume":"17","author":"Palermo","year":"2008","journal-title":"Reproductive BioMedicine Online"},{"key":"2026010712150460300_bib58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0029-1202309","article-title":"ICSI: where we have been and where we are going","volume":"27","author":"Palermo","year":"2009","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712150460300_bib59","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/978-1-4939-0659-8_18","article-title":"Treatment of male infertility","volume":"1154","author":"Palermo","year":"2014","journal-title":"Methods in Molecular Biology"},{"key":"2026010712150460300_bib60","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/978-1-4939-0659-8_26","article-title":"Safety of intracytoplasmic sperm injection","volume":"1154","author":"Palermo","year":"2014","journal-title":"Methods in Molecular Biology"},{"key":"2026010712150460300_bib61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1055\/s-0035-1546825","article-title":"To ICSI or not to ICSI","volume":"33","author":"Palermo","year":"2015","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712150460300_bib62","doi-asserted-by":"crossref","first-page":"e0166222","DOI":"10.1371\/journal.pone.0166222","article-title":"Identifying maternal constraints on fetal growth and subsequent perinatal outcomes using a multiple embryo implantation model.","volume":"11","author":"Pereira","year":"2016","journal-title":"PLoS ONE"},{"key":"2026010712150460300_bib63","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.0001-6349.2004.00476.x","article-title":"Neonatal outcome in a Danish national cohort of 8602 children born after in vitro fertilization or intracytoplasmic sperm injection: the role of twin pregnancy","volume":"83","author":"Pinborg","year":"2004","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"2026010712150460300_bib64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/oxfordjournals.humrep.a136644","article-title":"Chromosome analysis of human oocytes and embryos: does delayed fertilization increase chromosome imbalance?","volume":"3","author":"Plachot","year":"1988","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib65","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/humrep\/deh511","article-title":"Psychological follow-up study of 5-year-old ICSI children","volume":"19","author":"Ponjaert-Kristoffersen","year":"2004","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib66","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.1542\/peds.2004-1445","article-title":"International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments","volume":"115","author":"Ponjaert-Kristoffersen","year":"2005","journal-title":"Pediatrics"},{"key":"2026010712150460300_bib67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jama.2013.7222","article-title":"Autism and mental retardation among offspring born after in vitro fertilization","volume":"310","author":"Sandin","year":"2013","journal-title":"JAMA"},{"key":"2026010712150460300_bib68","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.fertnstert.2014.03.049","article-title":"Outcomes from infancy to adulthood after assisted reproductive technology","volume":"101","author":"Shankaran","year":"2014","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib69","first-page":"119","article-title":"The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age","volume":"32","author":"Tannus","year":"2017","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1055\/s-2005-872457","article-title":"Genomic imprinting and assisted reproductive technology: connections and potential risks","volume":"23","author":"Thompson","year":"2005","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712150460300_bib71","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1071\/RD9950269","article-title":"Intracytoplasmic sperm injection (ICSI): the Brussels experience","volume":"7","author":"Tournaye","year":"1995","journal-title":"Reproduction Fertility and Development"},{"key":"2026010712150460300_bib72","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0015-0282(16)57487-1","article-title":"Late intracytoplasmic sperminjection in unexpected failed fertilization in vitro: diagnostic or therapeutic?","volume":"63","author":"Tsirigotis","year":"1995","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib73","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0015-0282(16)54725-6","article-title":"Poor implantation of cryopreserved reinsemination-fertilized human embryos","volume":"56","author":"Tucker","year":"1991","journal-title":"Fertility and Sterility"},{"key":"2026010712150460300_bib74","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1093\/oxfordjournals.humrep.a135773","article-title":"Obstetric outcome of 424 pregnancies after intracytoplasmic sperm injection","volume":"10","author":"Wisanto","year":"1995","journal-title":"Human Reproduction"},{"key":"2026010712150460300_bib75","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/humrep\/der136","article-title":"Follow-up of children born after ICSI with epididymal spermatozoa","volume":"26","author":"Woldringh","year":"2011","journal-title":"Human Reproduction"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/154\/6\/REP-17-0344.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/154\/6\/F61\/64122124\/rep-17-0344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/154\/6\/F61\/64122124\/rep-17-0344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:16:48Z","timestamp":1767806208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/154\/6\/F61\/8235095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,1]]},"references-count":75,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-17-0344","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,12,1]]},"published":{"date-parts":[[2017,12,1]]}}}