{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:42:22Z","timestamp":1769060542810,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD31 has been shown to play a role in endothelial cell migration and angiogenesis, which are critical to the formation and function of the endometrium and myometrium in uterine development during early pregnancy. However, the role of CD31 in uterine receptivity during blastocyst implantation is poorly understood. The pregnancy rate in CD31\u2212\/\u2212 female mice mated with CD31+\/+ male mice was higher than that observed in CD31+\/+ female mice mated with CD31+\/+ male mice. During the receptive phase of implantation, uterine glands were more developed in CD31\u2212\/\u2212 mice than in CD31+\/+ mice, and the uterine weights of CD31\u2212\/\u2212 mice were increased. Leukemia inhibitory factor (LIF) was highly expressed in the CD31\u2212\/\u2212 mice during implantation and the expression of LIF was up-regulated by estradiol-17\u03b2 (E2)\u2009+\u2009progesterone (P4) in ovariectomized CD31\u2212\/\u2212 mice, compared with CD31+\/+ mice at 8\u2009h after hormone treatment. E2-induced protein synthesis was inhibited by P4 in the CD31+\/+ uterus, but not in the uterus of CD31\u2212\/\u2212 mice. Also, STAT3, HAND2, LIF, and mTOR signals were enhanced in CD31\u2212\/\u2212 mice. Stromal DNA replication was highly activated in the uterus of CD31\u2212\/\u2212 mice, manifested by upregulated cyclin series signaling and PCNA expression after E2\u2009+\u2009P4treatment. Collectively, CD31 inhibits E2-mediated epithelial proliferation via recruitment and phosphorylation of SHP-2 upon receiving P4signal in early pregnancy.<\/jats:p>","DOI":"10.1530\/rep-17-0419","type":"journal-article","created":{"date-parts":[[2017,8,5]],"date-time":"2017-08-05T20:10:18Z","timestamp":1501963818000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["The critical role of uterine CD31 as a post-progesterone signal in early pregnancy"],"prefix":"10.1093","volume":"154","author":[{"given":"Seo-Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Chonbuk National University Medical School, Jeonju, Korea"},{"name":"National Creative Research Laboratory for Ca2+ Signaling Network , Chonbuk National University Medical School, Jeonju, 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