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After estrus synchronization, 24 Hu sheep were assigned to three groups based on the nutrient requirement recommended for maintenance (M): 1\u2009\u00d7\u2009M (Control), 1.5\u2009\u00d7\u2009M (S) and 0.5\u2009\u00d7\u2009M (R) during days 7\u201314 of their estrous cycle. The results indicated that undernourishment significantly increased the counts and volume of follicles &amp;lt;2.5\u2009mm and decreased the counts and volume of follicles \u22652.5\u2009mm (P\u2009&amp;lt;\u20090.05). Feed restriction altered the plasma and follicular redox balance within follicles \u22652.5\u2009mm by inhibiting total antioxidant capacity, increasing malondialdehyde concentration (P\u2009&amp;lt;\u20090.05) and reducing the mRNA expression levels of superoxide dismutase 2 (SOD2) and glutathione peroxidase (GSH-PX), as well as the activities of total SOD and GSH-PX. Feed restriction also attenuated B-cell lymphoma-2 (BCL2) but enhanced Bcl-2-associated X protein (BAX) and BAX\/BCL2 transcription and translation levels in granulosa cells (P\u2009&amp;lt;\u20090.05). Uniform staining intensities of AKT and P-AKT-Ser473 were observed in each follicle stage, whereas weaker P-AKT-Thr308 staining in the antral follicle than in the pre-antral follicle suggested possible involvement of P-AKT-Thr308 during the beginning of follicle development. P-AKT-Ser473 levels in follicles \u22652.5\u2009mm was significantly reduced in the R group (P\u2009&amp;lt;\u20090.05). The results presented in this study demonstrate that suppressed folliculogenesis caused by feed restriction might be associated with attenuated AKT signaling, reduced follicular antioxidant capacity and enhanced granulosa cells apoptosis.<\/jats:p>","DOI":"10.1530\/rep-17-0446","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T20:35:12Z","timestamp":1508877312000},"page":"37-49","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["Acute nutrient treatment causes alterations in intra-follicular antioxidation and AKT signaling"],"prefix":"10.1093","volume":"155","author":[{"given":"H T","family":"Nie","sequence":"first","affiliation":[{"name":"Jiangsu Engineering Technology Research Center of Meat Sheep and Goat Industry , College of Animal Science and Technology, Nanjing Agricultural University, Nanjing City, JiangSu Province, People\u2019s Republic of 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