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Here the impact of placentally mediated prenatal growth restriction followed by postnatal nutrient abundance on growth, glucose metabolism and body composition was assessed in both sexes at key stages from birth to mid-adult life. Singleton-bearing adolescent dams were fed control or high nutrient intakes to induce normal or growth-restricted pregnancies respectively. Restricted lambs had ~40% reduced birthweight. Fractional growth rates were higher in restricted lambs of both sexes predominantly during suckling\/juvenile phases. Thereafter, rates and patterns of growth differed by sex. Absolute catch-up was not achieved and restricted offspring had modestly reduced weight and stature at mid-adulthood necropsy (~109 weeks). Dual-energy X-ray absorptiometry revealed lower bone mineral density in restricted vs normal lambs at 11, 41, 64 and 107 weeks, with males\u2009&amp;gt;\u2009females from 41 weeks onwards. Body fat percentage was higher in females vs males throughout, in restricted vs normal lambs at weaning (both sexes) and in restricted vs normal females at mid-adulthood. Insulin secretion after glucose challenge was greater in restricted vs normal of both sexes at 7 weeks and in restricted males at 32 weeks. In both sexes, fasting glucose concentrations were greater in restricted offspring across the life course, while glucose area under the curve after challenge was higher in restricted offspring at 32, 60, 85 and 106 weeks, indicative of persistent glucose intolerance. Therefore, prenatal growth restriction has negative consequences for body composition and metabolism throughout the life course with the effects modulated by sex differences in postnatal growth rates, fat deposition and bone mass accrual.<\/jats:p>","DOI":"10.1530\/rep-18-0048","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T12:05:11Z","timestamp":1526990711000},"page":"103-119","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["Ovine prenatal growth restriction impacts glucose metabolism and body composition throughout life in both sexes"],"prefix":"10.1093","volume":"156","author":[{"given":"Jacqueline M","family":"Wallace","sequence":"first","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S","family":"Milne","sequence":"additional","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond P","family":"Aitken","sequence":"additional","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham W","family":"Horgan","sequence":"additional","affiliation":[{"name":"Biomathematics and Statistics Scotland , Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare L","family":"Adam","sequence":"additional","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"2026010712172994000_bib2","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1210\/en.2012-1134","article-title":"In vivo changes in central and peripheral insulin insensitivity in a large animal model of obesity","volume":"153","author":"Adam","year":"2012","journal-title":"Endocrinology"},{"key":"2026010712172994000_bib1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.ijdevneu.2013.07.005","article-title":"Impact of birth weight and gender on early postnatal hypothalamic energy balance regulatory gene expression in the young lamb","volume":"31","author":"Adam","year":"2013","journal-title":"International Journal of Developmental Neuroscience"},{"key":"2026010712172994000_bib3","volume-title":"An Advisory Manual Prepared by the AFRC Technical Committee on Responses to Nutrients","author":"AFRC Energy and Protein Requirements of Ruminants","year":"1993"},{"key":"2026010712172994000_bib4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/obr.12109","article-title":"Size at birth and abdominal adiposity in adults: a systematic review and meta-analysis","volume":"15","author":"Ara\u00fajo de Franca","year":"2014","journal-title":"Obesity Reviews"},{"key":"2026010712172994000_bib5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1365-2265.2010.03918.x","article-title":"Foetal and postnatal growth and bone mass at 6 months: the Generation R study","volume":"74","author":"Ay","year":"2011","journal-title":"Clinical Endocrinology"},{"key":"2026010712172994000_bib6","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/00003081-200606000-00009","article-title":"Adult consequences of fetal growth restriction","volume":"49","author":"Barker","year":"2006","journal-title":"Clinical Obstetrics and Gynecology"},{"key":"2026010712172994000_bib7","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12916-016-0690-7","article-title":"Birthweight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses","volume":"14","author":"Belbasis","year":"2016","journal-title":"BMC Medicine"},{"key":"2026010712172994000_bib8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0002-9378(00)70513-8","article-title":"Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. 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