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The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. Four-week-old ICR females (n\u2009=\u200916 in each experimental group) were exposed to vehicle control (VC), BPS1 (0.001\u2009ng BPS.g\/bw\/day), BPS2 (0.1\u2009ng.g\/bw\/day), BPS3 (10\u2009ng.g\/bw\/day) and BPS4 (100\u2009ng.g\/bw\/day) for 4 weeks. Ovaries were subjected to stereology and nano liquid chromatography-mass spectrometry (LC\/MS). Simultaneously, metaphase II oocytes were obtained after pregnant mare serum gonadotrophin and human chorionic gonadotrophin administration, followed by immunostaining. In particular, mating and two-cell embryo flushing were performed. We observed that BPS decreases the amount of ovarian follicles and BPS2 (0.1\u2009ng.g\/bw\/day) affects the volume of antral follicles. Accordingly, ovarian proteome is affected after BPS2 treatment. While BPS2 dosing results mainly in cytoskeletal damage in matured oocytes, the effects of BPS3 and BPS4 seem to be due instead to epigenetic alterations in oocytes. Arguably, these changes lead to observed affection of in vivo fertilization rate after BPS3 and BPS4 treatment. BPS significantly affects female reproduction astoundingly in extremely low doses. These findings underline the necessity to assess the risk of ongoing BPS exposure for public health.<\/jats:p>","DOI":"10.1530\/rep-18-0092","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T11:50:16Z","timestamp":1525953016000},"page":"47-57","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":69,"title":["Long-term exposure to very low doses of bisphenol S affects female reproduction"],"prefix":"10.1093","volume":"156","author":[{"given":"Jan","family":"Nevoral","sequence":"first","affiliation":[{"name":"Biomedical Center , Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"},{"name":"Department of Histology and Embryology , Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslav","family":"Kolinko","sequence":"additional","affiliation":[{"name":"Biomedical Center , Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"},{"name":"Department of Histology and Embryology , Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Moravec","sequence":"additional","affiliation":[{"name":"Biomedical Center , Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"\u017dalmanov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Animal Science , Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"Ho\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Animal Science , Prague, Czech 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