{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:26:53Z","timestamp":1785929213139,"version":"3.56.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Perivascular mesenchymal stem\/stromal cells can be isolated from the human endometrium using the surface marker SUSD2 and are being investigated for use in tissue repair. Mesenchymal stem\/stromal cells from other tissues modulate T cell responses via mechanisms including interleukin-10, prostaglandin E2, TGF-\u03b21 and regulatory T cells. Animal studies demonstrate that endometrial mesenchymal stem\/stromal cells can also modify immune responses to implanted mesh, but the mechanism\/s they employ have not been explored. We examined the immunomodulatory properties of human endometrial mesenchymal stem\/stromal cells on lymphocyte proliferation using mouse splenocyte cultures. Endometrial mesenchymal stem\/stromal cells inhibited mitogen-induced lymphocyte proliferation in vitro in a dose-dependent manner. Inhibition of lymphocyte proliferation was not affected by blocking the mouse interleukin-10 receptor or inhibiting prostaglandin production. Endometrial mesenchymal stem\/stromal cells continued to restrain lymphocyte proliferation in the presence of an inhibitor of TGF-\u03b2 receptors, despite a reduction in regulatory T cells. Thus, the in vitro inhibition of mitogen-induced lymphocyte proliferation by endometrial mesenchymal stem\/stromal cells occurs by a mechanism distinct from the interleukin-10, prostaglandin E2, TGF-\u03b21 and regulatory T cell-mediated mechanisms employed by MSC from other tissues. eMSCs were shown to produce interleukin-17A and Dickkopf-1 which may contribute to their immunomodulatory properties. In contrast to MSC from other sources, systemic administration of endometrial mesenchymal stem\/stromal cells did not inhibit swelling in a T cell-mediated model of skin inflammation. We conclude that, while endometrial mesenchymal stem\/stromal cells can modify immune responses, their immunomodulatory repertoire may not be sufficient to restrain some T cell-mediated inflammatory events.<\/jats:p>","DOI":"10.1530\/rep-18-0266","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T13:17:07Z","timestamp":1540473427000},"page":"43-52","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":11,"title":["Endometrial mesenchymal stem\/stromal cell modulation of T cell proliferation"],"prefix":"10.1093","volume":"157","author":[{"given":"Xiaoqing","family":"Yang","sequence":"first","affiliation":[{"name":"The Ritchie Centre , Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"Department of Obstetrics and Gynecology , Affiliated Hospital of Nantong University, NanTong, Jiangsu, 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