{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:30:22Z","timestamp":1790105422275,"version":"4.0.1"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spermatogonial stem cells (SSCs) are one of the most significant stem cells with the potentials of self-renewal, differentiation, transdifferentiation and dedifferentiation, and thus, they have important applications in reproductive and regenerative medicine. They can transmit the genetic and epigenetic information across generations, which highlights the importance of the correct establishment and maintenance of epigenetic marks. Accurate transcriptional and post-transcriptional regulation is required to support the highly coordinated expression of specific genes for each step of spermatogenesis. Increasing evidence indicates that non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), play essential roles in controlling gene expression and fate determination of male germ cells. These ncRNA molecules have distinct characteristics and biological functions, and they independently or cooperatively modulate the proliferation, apoptosis and differentiation of SSCs. In this review, we summarized the features, biological function and fate of mouse and human SSCs, and we compared the characteristics of lncRNAs and circRNAs. We also addressed the roles and mechanisms of lncRNAs and circRNAs in regulating mouse and human SSCs, which would add novel insights into the epigenetic mechanisms underlying mammalian spermatogenesis and provide new approaches to treat male infertility.<\/jats:p>","DOI":"10.1530\/rep-18-0517","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T11:41:26Z","timestamp":1554205286000},"page":"R15-R25","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":34,"title":["Regulation of long non-coding RNAs and circular RNAs in spermatogonial stem cells"],"prefix":"10.1093","volume":"158","author":[{"given":"Fan","family":"Zhou","sequence":"first","affiliation":[{"name":"Renji-Med X Clinical Stem Cell Research Center , Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan Normal University School of Medicine , Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hunan Normal University School of Medicine , Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuping","family":"He","sequence":"additional","affiliation":[{"name":"Renji-Med X Clinical Stem Cell Research Center , Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Hunan Normal University School of Medicine , Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2026010712202198400_bib1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1093\/molehr\/gas025","article-title":"The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?","volume":"18","author":"Aeckerle","year":"2012","journal-title":"Molecular Human Reproduction"},{"key":"2026010712202198400_bib2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010712202198400_bib3","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1080\/15476286.2014.996070","article-title":"Genome wide chromatin occupancy of mrhl RNA and its role in gene regulation in mouse spermatogonial cells","volume":"11","author":"Akhade","year":"2014","journal-title":"RNA Biology"},{"key":"2026010712202198400_bib4","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1172\/JCI75943","article-title":"PAX7 expression defines germline stem cells in the adult testis","volume":"124","author":"Aloisio","year":"2014","journal-title":"Journal of Clinical Investigation"},{"key":"2026010712202198400_bib5","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1128\/MCB.00006-12","article-title":"Mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5\/p68 in mouse spermatogonial cells","volume":"32","author":"Arun","year":"2012","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712202198400_bib6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing","volume":"56","author":"Ashwal-Fluss","year":"2014","journal-title":"Molecular Cell"},{"key":"2026010712202198400_bib7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev.genet.37.040103.103949","article-title":"Pseudogenes: are they \u2018junk\u2019 or functional DNA?","volume":"37","author":"Balakirev","year":"2003","journal-title":"Annual Review of Genetics"},{"key":"2026010712202198400_bib8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1083\/jcb.74.1.68","article-title":"Spermatogenic cells of the prepuberal mouse. 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